Journal
NATURE REVIEWS MICROBIOLOGY
Volume 15, Issue 1, Pages 55-63Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2016.142
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Funding
- Australian National Health and Medical Research Council (NHMRC)
- Australian Research Council (ARC)
- Brawn Foundation
- Faculty of Health and Medicine at the University of Newcastle, Australia
- NHMRC
- Rainbow Foundation
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The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut lung axis. Although the gut lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
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