Journal
NATURE REVIEWS MICROBIOLOGY
Volume 15, Issue 2, Pages 96-108Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrmicro.2016.157
Keywords
-
Categories
Funding
- US National Institutes of Health [R01AI108992, T32AI060537]
- Scholar in the Biomedical Sciences award from the Pew Charitable Trusts
- US National Science Foundation [1144247]
- Investigators in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Fund
Ask authors/readers for more resources
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal morphologies in C. albicans was thought to underlie much of the variation in virulence observed in different host tissues. However, novel yeast-like cell morphotypes, including opaque(a/a), grey and gastrointestinally induced transition (GUT) cell types, were recently reported that exhibit marked differences in vitro and in animal models of commensalism and disease. In this Review, we explore the characteristics of the classic cell types yeast, hyphae, pseudohyphae and chlamydospores as well as the newly identified yeast-like morphotypes. We highlight emerging knowledge about the associations of these different morphotypes with different host niches and virulence potential, as well as the environmental cues and signalling pathways that are involved in the morphological transitions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available