Related references
Note: Only part of the references are listed.Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective
Wen Lin et al.
PHARMACEUTICAL RESEARCH (2022)
Physiologically-based toxicokinetic modeling of human dermal exposure to diethyl phthalate: Application to health risk assessment
Man Hu et al.
CHEMOSPHERE (2022)
Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling
Hyeon-Cheol Jeong et al.
TRANSLATIONAL AND CLINICAL PHARMACOLOGY (2022)
Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions
Nina Hanke et al.
PHARMACEUTICAL RESEARCH (2021)
Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates
Lukas Kovar et al.
PHARMACEUTICS (2020)
A workflow to build PBTK models for novel species
Sebastian Schneckener et al.
ARCHIVES OF TOXICOLOGY (2020)
1,1-Difluoroethane Detection Time in Blood after Inhalation Abuse Estimated by Monte Carlo PBPK Modeling
Raul Huet et al.
PHARMACEUTICS (2020)
PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data
Alexander B. Cooper et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)
Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative
Dimosthenis A. Sarigiannis et al.
ENVIRONMENTAL RESEARCH (2019)
In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds
Eric Fabian et al.
ARCHIVES OF TOXICOLOGY (2019)
Physiologically Based Pharmacokinetic Modeling in Pregnancy: A Systematic Review of Published Models
Andre Dallmann et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Karol Jaroch et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)
Evaluating parameter availability for physiologically based pharmacokinetic (PBPK) modeling of perfluorooctanoic acid (PFOA) in zebrafish
Manoochehr Khazaee et al.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2018)
Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data
Jochem Louisse et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2017)
Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs
Frauke Assmus et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples
Zhoumeng Lin et al.
TOXICOLOGICAL SCIENCES (2017)
The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research
Patrick Poulin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2016)
Modelling ecological and human exposure to POPs in Venice lagoon - Part II: Quantitative uncertainty and sensitivity analysis in coupled exposure models
Artur Radomyski et al.
SCIENCE OF THE TOTAL ENVIRONMENT (2016)
Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research
Patrick Poulin
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Development and Application of a Multiroute Physiologically Based Pharmacokinetic Model for Oxytetracycline in Dogs and Humans
Zhoumeng Lin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations
Markus Krauss et al.
PLOS ONE (2015)
Understanding Receptor-Mediated Effects in Rainbow Trout: In Vitro-in Vivo Extrapolation Using Physiologically Based Toxicokinetic Models
Markus Brinkmann et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)
A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population
Ruijuan Xu et al.
PLOS ONE (2014)
Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients
M. Gajewska et al.
TOXICOLOGY LETTERS (2014)
A Simplified PBPK Modeling Approach for Prediction of Pharmacokinetics of Four Primarily Renally Excreted and CYP3A Metabolized Compounds During Pregnancy
Binfeng Xia et al.
AAPS JOURNAL (2013)
Application of Bayesian Population Physiologically Based Pharmacokinetic (PBPK) Modeling and Markov Chain Monte Carlo Simulations to Pesticide Kinetics Studies in Protected Marine Mammals: DDT, DDE, and DDD in Harbor Porpoises
Liesbeth Weijs et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)
Quantitative Structure-Activity Relationship Models of Clinical Pharmacokinetics: Clearance and Volume of Distribution
Vijay K. Gombar et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling
Guo-fu Li et al.
ACTA PHARMACOLOGICA SINICA (2012)
A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4
Lu Gaohua et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Update 1 of: Sensitivity Analysis for Chemical Models
Andrea Saltelli et al.
CHEMICAL REVIEWS (2012)
Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy
Khaled Abduljalil et al.
CLINICAL PHARMACOKINETICS (2012)
Partitioning of Organic Chemicals to Storage Lipids: Elucidating the Dependence on Fatty Acid Composition and Temperature
Anett Geisler et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)
Partitioning of Neutral Organic Compounds to Structural Proteins
Satoshi Endo et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)
Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative method
Patrick Poulin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Model Selection and Psychological Theory: A Discussion of the Differences Between the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC)
Scott I. Vrieze
PSYCHOLOGICAL METHODS (2012)
Serum Albumin Binding of Structurally Diverse Neutral Organic Compounds: Data and Models
Satoshi Endo et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2011)
Capacities of Membrane Lipids to Accumulate Neutral Organic Chemicals
Satoshi Endo et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)
Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development
Feras Khalil et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)
An integrated QSAR-PBPK modelling approach for predicting the inhalation toxicokinetics of mixtures of volatile organic chemicals in the rat
K. Price et al.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2011)
A workflow for global sensitivity analysis of PBPK models
Kevin McNally et al.
FRONTIERS IN PHARMACOLOGY (2011)
A Semiphysiological Population Model for Prediction of the Pharmacokinetics of Drugs under Liver and Renal Disease Conditions
Ashley Strougo et al.
DRUG METABOLISM AND DISPOSITION (2011)
Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans
Lisa M. Sweeney et al.
FOOD AND CHEMICAL TOXICOLOGY (2010)
A rapid computational filter for predicting the rate of human renal clearance
Stuart W. Paine et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2010)
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion
K. Sandy Pang et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2010)
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
Frederic Y. Bois et al.
TOXICOLOGY (2010)
Modelling and PBPK Simulation in Drug Discovery
Hannah M. Jones et al.
AAPS JOURNAL (2009)
Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction
Jonathon N. Bauman et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly
Chad M. Thompson et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2009)
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
R. Scott Obach et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Physiology-Based Simulations of a Pathological Condition Prediction of Pharmacokinetics in Patients with Liver Cirrhosis
Andrea N. Edginton et al.
CLINICAL PHARMACOKINETICS (2008)
Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis
Sheila Annie Peters
CLINICAL PHARMACOKINETICS (2008)
Emerging evidence of the impact of kidney disease on drug metabolism and transport
T. D. Nolin et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging
Daniel P. Barboriak et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2008)
Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity
Rasmus Jansson et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Simulating pharmacokinetic and pharmacodynamic fuzzy-parameterized models: a comparison of numerical methods
Kok-Yong Seng et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2007)
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation
John W. Nichols et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2007)
Estimation of interindividual pharmacokinetic variability factor for inhaled volatile organic chemicals using a probability-bounds approach
Andy Nong et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2007)
Mechanistic approaches to volume of distribution predictions: Understanding the processes
Trudy Rodgers et al.
PHARMACEUTICAL RESEARCH (2007)
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: Global sensitivity analysis for experimental design issues
Celine Brochot et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2007)
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish - I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models
John W. Nichols et al.
AQUATIC TOXICOLOGY (2006)
In silico renal clearance model using classical Volsurf approach
Munikumar R. Doddareddy et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)
Development and evaluation of a generic physiologically based pharmacokinetic model for children
Andrea N. Edginton et al.
CLINICAL PHARMACOKINETICS (2006)
Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate-to-strong bases
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Fuzzy simulation of pharmacokinetic models: Case study of whole body physiologically based model of diazepam
II Gueorguieva et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2004)
Whole body pharmacokinetic models
I Nestorov
CLINICAL PHARMACOKINETICS (2003)
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution
P Poulin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2002)
A whole-body physiologically based pharmacokinetic model incorporating dispersion concepts: Short and long time characteristics
RE Oliver et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2001)