Long-Term Exposure to PM2.5 and Mortality: A Cohort Study in China

We investigated the association of long-term exposure to atmospheric PM2.5 with non-accidental and cause-specific mortality in Yinzhou, China. From July 2015 to January 2018, a total of 29,564 individuals aged >= 40 years in Yinzhou were recruited for a prospective cohort study. We used the Cox proportional-hazards model to analyze the relationship of the 2-year average concentration of PM2.5 prior to the baseline with non-accidental and cause-specific mortality. The median PM2.5 concentration was 36.51 mu g/m(3) (range: 25.57-45.40 mu g/m(3)). In model 4, the hazard ratios per 10 mu g/m(3) increment in PM2.5 were 1.25 (95%CI: 1.04-1.50) for non-accidental mortality and 1.38 (95%CI:1.02-1.86) for cardiovascular disease mortality. We observed no associations between PM2.5 and deaths from respiratory disease or cancer. In the subgroup analysis, interactions were observed between PM2.5 and age, as well as preventive measures on hazy days. The observed association between long-term exposure to atmospheric PM2.5 at a relatively moderate concentration and the risk of non-accidental and cardiovascular disease mortality among middle-aged and elderly Chinese adults could provide evidence for government decision-makers to revise environmental policies towards a more stringent standard.

Automated summary

We investigated the association between long-term exposure to atmospheric PM2.5 and non-accidental and cause-specific mortality in Yinzhou, China. Moderate PM2.5 concentration was found to be associated with an increased risk of non-accidental and cardiovascular disease mortality among middle-aged and elderly Chinese adults. No associations were observed with respiratory disease or cancer mortality. Interactions between PM2.5 and age, as well as preventive measures on hazy days, were also observed.