Journal
NATURE REVIEWS GENETICS
Volume 17, Issue 11, Pages 661-678Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2016.112
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Funding
- European Horizon (H2020) MuG project [676556]
- Centre National de la Recherche Scientifique (CNRS)
- European Network of Excellence EpiGeneSys
- Agence Nationale de la Recherche (EpiDevoMath)
- Fondation pour la Recherche Medicale [DEI20151234396]
- INSERM/Plan Cancer Epigenetics and cancer program (grant acronym MMTT)
- Laboratory of Excellence EpiGenMed
- Fondation ARC pour la Recherche sur le Cancer
- Sir Henry Wellcome Postdoctoral Fellowship [WT100136MA]
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Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset and maintained. In this Review, we discuss the insights into chromatin architecture that have been gained through recent technological developments in quantitative biology, genomics and cell and molecular biology approaches and explain how these new concepts have been used to address important biological questions in development and disease.
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