Journal
NATURE REVIEWS GENETICS
Volume 17, Issue 9, Pages 567-578Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2016.78
Keywords
-
Categories
Funding
- European Research Council [309834, 669207]
- European Research Council (ERC) [309834, 669207] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The study of de novo protein-coding genes is maturing from the ad hoc reporting of individual cases to the systematic analysis of extensive genomic data from several species. We identify three key challenges for this emerging field: understanding how best to identify de novo genes, how they arise and why they spread. We highlight the intellectual challenges of understanding how a de novo gene becomes integrated into pre-existing functions and becomes essential. We suggest that, as with protein sequence evolution, antagonistic co-evolution may be key to de novo gene evolution, particularly for new essential genes and new cancer-associated genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available