Journal
NATURE REVIEWS GENETICS
Volume 17, Issue 8, Pages 459-469Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2016.57
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Funding
- European Research Council [ERC-617457- PHYLOCANCER]
- Spanish Government [BFU2012-33038, BFU2015-63774-P]
- Spanish Government (Research Personnel Training (FPI) graduate fellowship) [BES-2013-067181]
- Spanish Government (Juan de la Cierva postdoctoral fellowship) [FPDI-2013-17503]
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Computer simulation of genomic data has become increasingly popular for assessing and validating biological models or for gaining an understanding of specific data sets. Several computational tools for the simulation of next-generation sequencing (NGS) data have been developed in recent years, which could be used to compare existing and new NGS analytical pipelines. Here we review 23 of these tools, highlighting their distinct functionality, requirements and potential applications. We also provide a decision tree for the informed selection of an appropriate NGS simulation tool for the specific question at hand.
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