4.3 Article

Lung Function and Asthma Clinical Control in N-ERD Patients, Three-Year Follow-Up in the Context of Real-World Evidence

Related references

Note: Only part of the references are listed.
Article Allergy

Long-term clinical outcomes of aspirin-exacerbated respiratory disease: Real-world data from an adult asthma cohort

Youngsoo Lee et al.

Summary: This study compared the long-term clinical outcomes between aspirin-exacerbated respiratory disease (AERD) and aspirin-tolerant asthma (ATA). The results showed that AERD patients had poorer lung function and more severe asthma exacerbations compared to ATA patients.

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

Article Otorhinolaryngology

Long-term role of zileuton in the treatment of chronic rhinosinusitis in aspirin exacerbated respiratory disease

Chadi A. Makary et al.

Summary: This study evaluated the long-term effect of zileuton on sinonasal outcomes in patients with AERD, finding that zileuton may help decrease the number of sinus surgeries needed.

AMERICAN JOURNAL OF OTOLARYNGOLOGY (2022)

Article Allergy

Aspirin desensitization and biologics in aspirin-exacerbated respiratory disease Efficacy, tolerability, and patient experience

Jyotsna Mullur et al.

Summary: The patterns of medication use and treatment experience with biologics and ATAD in patients with aspirin-exacerbated respiratory disease (AERD) need further investigation. The study found that concurrent use of biologics and ATAD was associated with lower efficacy, and among biologics, dupilumab had the highest efficacy.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2022)

Article Otorhinolaryngology

Chronic Rhinosinusitis Outcomes of Patients With Aspirin-Exacerbated Respiratory Disease Treated With Budesonide Irrigations: A Case Series

Rehab Talat et al.

Summary: This study demonstrates that treatment with intranasal budesonide irrigations can lead to significant improvement in sinonasal symptomatology in AERD with CRSwNP. There were improvements in SNOT-22 scores and polyp scores after treatment.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2022)

Article Allergy

Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease

Bogdan Jakiela et al.

Summary: The study investigated immune mediator profiles in the lower airways of patients with N-ERD, revealing significant heterogeneity in lower airway immune profiles of N-ERD patients, with a skew towards T2 response and eosinophilic inflammation. Blood eosinophilia appeared to be a useful predictor of airway T2 signature, but surrogate biomarkers had moderate performance in distinguishing different phenotypes of N-ERD patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Review Public, Environmental & Occupational Health

Real-world evidence to support regulatory decision making: New or expanded medical product indications

Jessica M. Franklin et al.

Summary: There is growing interest in utilizing real-world data (RWD) to produce real-world evidence (RWE) for medical product regulatory approval decisions. Pharmacoepidemiology has focused on real-world data and evidence for years, and recent emerging trends support the use of RWD for approval decisions.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2021)

Article Allergy

Inflammatory heterogeneity in aspirin-exacerbated respiratory disease

William C. Scott et al.

Summary: The study revealed differences in inflammatory cytokines levels between AERD and CRSwNP patients, with significant heterogeneity observed among AERD patients. Hierarchical cluster analysis identified 3 inflammatory subendotypes of AERD, each with distinct patterns of inflammation. Several lipid mediators were also associated with disease severity, but showed less variability compared to cytokines.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

Effect of LTRA in L-ASA Challenge for Aspirin-Exacerbated Respiratory Disease Diagnosis

Fernando Ramirez-Jimenez et al.

Summary: The study investigated the impact of leukotriene receptor antagonist (LTRA), montelukast, on lysine-acetylsalicylate (L-ASA) nasal challenge in patients with Aspirin-exacerbated respiratory disease (AERD). Results showed that AERD patients without LTRA exhibited a greater positive response to the L-ASA challenge compared to those taking LTRA, suggesting the discontinuation of LTRA treatment before the challenge for optimal diagnostic accuracy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Allergy

Determining the Best Tool Comparable with Global Initiative for Asthma Criteria for Assessing Pediatric Asthma Control

Aysegul Akan et al.

Summary: This study aimed to investigate the correlation between asthma control test (ACT) and Global Initiative for Asthma (GINA) criteria in children with asthma, showing that ACT exhibited higher comparability with GINA than pediatric asthma control test (PACT). Additionally, in older children, pediatric asthma quality of life questionnaire (PAQLQ) had better correlation with ACT and better comparability with GINA.

PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY (2021)

Article Respiratory System

Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma

Iida Vahatalo et al.

Summary: In adult-onset asthma, patients with uncontrolled disease showed better 12-year adherence to ICS treatment than those with controlled asthma. Among patients with uncontrolled asthma, adherence >= 80% was associated with more rapid lung function decline.

ERJ OPEN RESEARCH (2021)

Article Respiratory System

Lung function and side effects of Aspirin desensitization: a real world study

Turpeinen Heikki et al.

Summary: This study evaluated the effects of ATAD on lung functions and respiratory symptoms in 67 patients with N-ERD. It found that ATAD had little effect on lower airway functions, but side effects were common and led to high discontinuation rates, with patients often stopping treatment due to lack of response or side effects.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2021)

Article Allergy

Safety and Efficacy of Aspirin Desensitization Combined With Long-Term Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease

R. Li et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2020)

Review Medicine, General & Internal

Airway Remodeling in Asthma

Kenneth P. Hough et al.

FRONTIERS IN MEDICINE (2020)

Review Allergy

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

Merin E. Kuruvilla et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

Review Allergy

Aspirin-exacerbated respiratory disease (AERD): Current understanding of AERD

Masami Taniguchi et al.

ALLERGOLOGY INTERNATIONAL (2019)

Article Cardiac & Cardiovascular Systems

Inhaled corticosteroids and asthma control in adult-onset asthma: 12-year follow-up study

Iida Vahatalo et al.

RESPIRATORY MEDICINE (2018)

Letter Allergy

A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease

Katherine L. Tuttle et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

Article Allergy

Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial

Thomas R. Schneider et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

Review Medicine, General & Internal

Aspirin-Exacerbated Respiratory Disease

Andrew A. White et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Medicine, Research & Experimental

Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician

Lawrence Blonde et al.

ADVANCES IN THERAPY (2018)

Article Respiratory System

Physiopathology and genetics in aspirin-exacerbated respiratory disease

Gandhi F. Pavon-Romero et al.

EXPERIMENTAL LUNG RESEARCH (2017)

Article Allergy

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease

Whitney W. Stevens et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

Article Allergy

Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature

Jessica P. Rajan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Factors associated with asthma control in patients with aspirin-exacerbated respiratory disease

Grazyna Bochenek et al.

RESPIRATORY MEDICINE (2015)

Review Respiratory System

Medication adherence and the risk of severe asthma exacerbations: a systematic review

Marjolein Engelkes et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Allergy

Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma

Michael Schatz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Review Respiratory System

Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies

Ezgi Ozyilmaz et al.

BMC PULMONARY MEDICINE (2014)

Article Allergy

Change in Asthma Control Over Time: Predictors and Outcomes

Michael Schatz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

Review Respiratory System

Non-adherence in difficult asthma and advances in detection

John T. Lindsay et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2013)