Journal
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume 13, Issue 5, Pages 261-280Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrgastro.2016.51
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Funding
- Novo Nordisk Fonden [NNF15OC0014040] Funding Source: researchfish
- The Danish Cancer Society [R98-A6446] Funding Source: researchfish
- Medical Research Council [MR/K017047/1] Funding Source: Medline
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Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the European Network for the Study of Cholangiocarcinoma (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.
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