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Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant
Paul M. Barr et al.
AMERICAN JOURNAL OF HEMATOLOGY (2009)
PKC inhibitors: potential in T cell-dependent immune diseases
Gottfried Baier et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Protein kinase C isoforms: Multi-functional regulators of cell life and death
Mary E. Reyland
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
PKCθ and Itk functionally interact during primary mouse CD3+ T cell activation
Nikolaus Thuille et al.
IMMUNOLOGY LETTERS (2009)
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer
Karen-Lise Garm Spindler et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2009)
A phase II study of oral enzastaurin in patients with metastatic breast cancer previously treated with an anthracycline and a taxane containing regimen
Lida Mina et al.
INVESTIGATIONAL NEW DRUGS (2009)
The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail
Christine M. Gould et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
ROCK Mediates Phorbol Ester-induced Apoptosis in Prostate Cancer Cells via p21Cip1 Up-regulation and JNK
Liqing Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Stimulation of protein kinase C-α suppresses colon cancer cell proliferation by down-regulation of β-catenin
Jungsug Gwak et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Protein Kinase C Alpha (PKCα) Regulates Growth and Invasion of Endometrial Cancer Cells
James M. Haughian et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes
Juergen Wagner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Protein Kinase C zeta Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo
Anita S. Galvez et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
PKC-Mediated Secretion of Death Factors in LNCaP Prostate Cancer Cells Is Regulated by Androgens
Liqing Xiao et al.
MOLECULAR CARCINOGENESIS (2009)
PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo
Thomas Gruber et al.
MOLECULAR IMMUNOLOGY (2009)
Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression
C. Lintas et al.
MOLECULAR PSYCHIATRY (2009)
aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
Hitoshi Ishiguro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation
Thomas Gruber et al.
SCIENCE SIGNALING (2009)
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma
F. Morschhauser et al.
ANNALS OF ONCOLOGY (2008)
PKC-θ selectively controls the adhesion-stimulating molecule Rap1
Thomas Letschka et al.
BLOOD (2008)
Protein kinase Cδ expression in breast cancer as measured by real-time PCR, western blotting and ELISA
E. McKiernan et al.
BRITISH JOURNAL OF CANCER (2008)
Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer
Geoffrey Y. Ku et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2008)
Atypical protein kinase C phosphorylates IKKαβ in transformed non-malignant and malignant prostate cell survival
Hla Y. Win et al.
CANCER LETTERS (2008)
Regulatory T cells and immune tolerance
Shimon Sakaguchi et al.
CELL (2008)
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
Shelly R. Calcagno et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival
Angus J. Cameron et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Rac regulates the interaction of fascin with protein kinase C in cell migration
Maddy Parsons et al.
JOURNAL OF CELL SCIENCE (2008)
Differential requirement of PKC-θ in the development and function of natural regulatory T cells
Sonal Gupta et al.
MOLECULAR IMMUNOLOGY (2008)
Activation of epidermal Akt by diverse mouse skin tumor promoters
Jerry Lu et al.
MOLECULAR CANCER RESEARCH (2007)
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase Cδ-dependent mechanism
Joaquin Villar et al.
CANCER RESEARCH (2007)
Protein kinase Cδ and apoptosis
M. E. Reyland
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Cutting edge: Atypical PKCs regulate T lymphocyte polarity and scanning behavior
Eliana Real et al.
JOURNAL OF IMMUNOLOGY (2007)
Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer
J. W. Assender et al.
JOURNAL OF CLINICAL PATHOLOGY (2007)
Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer
Moammir H. Aziz et al.
CANCER RESEARCH (2007)
Induction of apoptosis is driven by nuclear retention of protein kinase Cδ
Tracie A. DeVries-Seimon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: A study of the Princess Margaret Hospital Phase II consortium
Stephen Welch et al.
GYNECOLOGIC ONCOLOGY (2007)
Protein kinase Cε makes the life and death decision
Alakananda Basu et al.
CELLULAR SIGNALLING (2007)
Protein kinase C α is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells
Lisa B. Frankel et al.
BREAST CANCER RESEARCH AND TREATMENT (2007)
Protein kinase Cε is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner
Kyung-Mi Bae et al.
CANCER RESEARCH (2007)
Protein kinase Cδ regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL
Jennifer S. Y. Ma et al.
JOURNAL OF IMMUNOLOGY (2007)
Protein kinase C δ enhances proliferation and survival of murine mammary cells
Valeria C. Grossoni et al.
MOLECULAR CARCINOGENESIS (2007)
Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors
Martin J. Edelman et al.
CLINICAL CANCER RESEARCH (2007)
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer
Meera Nanjundan et al.
CANCER RESEARCH (2007)
A major role of PKC θ and NFκB in the regulation of hTERT in human T lymphocytes
Wei-Yun Sheng et al.
FEBS LETTERS (2006)
The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study
M. J. Millward et al.
BRITISH JOURNAL OF CANCER (2006)
Targeted disruption of protein kinase Cε reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
Quintin Pan et al.
CANCER RESEARCH (2006)
Protein kinase-ζ inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells
Reba Mustafi et al.
MOLECULAR CANCER RESEARCH (2006)
Protein kinase c α but not PKCζ suppresses intestinal tumor formation in ApcMin/+ mice
Henrik Oster et al.
CANCER RESEARCH (2006)
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma
JA Ajani et al.
INVESTIGATIONAL NEW DRUGS (2006)
Upregulation and activation of PKCα by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCa and Src inhibitors
M. Tan et al.
ONCOGENE (2006)
A phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate for patients with relapsed/refractory malignancies
D Schaar et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Regulatory T cells inhibit protein kinase Cθ recruitment to the immune synapse of naive T cells with the same antigen specificity
Adriana Sumoza-Toledo et al.
JOURNAL OF IMMUNOLOGY (2006)
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCι as a biomarker and potential oncogene in ovarian carcinoma
Lin Zhang et al.
CANCER RESEARCH (2006)
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-sinall-cell lung cancer
L Paz-Ares et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
A randomized phase II trial of interleukin-2 in combination with four different doses of bryostatin-1 in patients with renal cell carcinoma
AC Peterson et al.
INVESTIGATIONAL NEW DRUGS (2006)
Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade -: A key role for protein kinase Cδ
AM Gonzalez-Guerrico et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cδ-dependent induction of p21
M Nakagawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Atypical protein kinase Cι, is an oncogene in human non-small cell lung cancer
RP Regala et al.
CANCER RESEARCH (2005)
Protein kinase C δ stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest
AJ Fikaris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Protein kinase Cε is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
Q Pan et al.
CANCER RESEARCH (2005)
Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer
AM Eder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCI), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
JR Graff et al.
CANCER RESEARCH (2005)
Control of T helper 2 cell function and allergic airway inflammation by PKCξ
P Martín et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: A California cancer consortium phase I pharmacokinetic and molecular correlative trial
PN Lara et al.
CLINICAL CANCER RESEARCH (2005)
The PKCα-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals
YM Zhu et al.
CANCER RESEARCH (2005)
Role of protein kinase C-alpha in superficial bladder carcinoma recurrence
CZ Kong et al.
UROLOGY (2005)
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with fluorouracil in patients with advanced solid tumors
J Kortmansky et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226)
J Shirakawa et al.
INTERNATIONAL IMMUNOLOGY (2005)
PKCδ is involved in signal attenuation in CD3+ T cells
T Gruber et al.
IMMUNOLOGY LETTERS (2005)
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas
SA Grossman et al.
NEURO-ONCOLOGY (2005)
Phase II trial of the combination of bryostatin-1 and cisplatin in advanced or recurrent carcinoma of the cervix: a New York Gynecologic Oncology Group study
F Nezhat et al.
GYNECOLOGIC ONCOLOGY (2004)
Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo
NR Murray et al.
JOURNAL OF CELL BIOLOGY (2004)
A phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C α, administered as a 21-day infusion to patients with advanced ovarian carcinoma
R Advani et al.
CANCER (2004)
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
KA Sheppard et al.
FEBS LETTERS (2004)
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma
S Rao et al.
ANNALS OF ONCOLOGY (2004)
Protein kinase C θ is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
BJ Marsland et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cδ
RV Stahelin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Signaling pathways in Th2 development
KA Mowen et al.
IMMUNOLOGICAL REVIEWS (2004)
Integrin signaling links protein kinase Cε to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells
DQ Wu et al.
ONCOGENE (2004)
Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac1-dependent signaling pathway
J Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
WJ Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
E Galkina et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Protein kinase Cα (PKCα) acts upstream of PKCθ to activate IκB kinase and NF-κB in T lymphocytes
SA Trushin et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Protein kinase Cε interacts with Bax and promotes survival of human prostate cancer cells
MA McJilton et al.
ONCOGENE (2003)
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
Y Tanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Protein kinase Cβ1, a major regulator of TCR-CD28-activated signal transduction leading to IL-2 gene transcription and secretion
UE Dreikhausen et al.
INTERNATIONAL IMMUNOLOGY (2003)
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
N Watanabe et al.
NATURE IMMUNOLOGY (2003)
Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
DA Tonetti et al.
BRITISH JOURNAL OF CANCER (2003)
The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes
WY Sheng et al.
FEBS LETTERS (2003)
Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): Potential role in breast cancer
D Roychowdhury et al.
SEMINARS IN ONCOLOGY (2003)
Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis
WS Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells
N Yoshikawa et al.
LIFE SCIENCES (2003)
A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer
JD Winegarden et al.
LUNG CANCER (2003)
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination
F Triebel
TRENDS IN IMMUNOLOGY (2003)
Nuclear import of PKCδ is required for apoptosis:: identification of a novel nuclear import sequence
TA DeVries et al.
EMBO JOURNAL (2002)
Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus
HF Valenzuela et al.
CLINICAL IMMUNOLOGY (2002)
A randomized phase II study of two schedules of bryostatin-1 (NSC339555) in patients with advanced malignant melanoma - A National Cancer Institute of Canada Clinical Trials Group study
RG Tozer et al.
INVESTIGATIONAL NEW DRUGS (2002)
A requirement for CARMA1 in TCR-induced NF-κB activation
DH Wang et al.
NATURE IMMUNOLOGY (2002)
PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling
TT Su et al.
NATURE IMMUNOLOGY (2002)
Protein kinase Cζ phosphorylates nuclear factor of activated T cells and regulates its transactivating activity
B San-Antonio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse
JY Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Protein kinase C β controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase α
K Saijo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
E Weisberg et al.
CANCER CELL (2002)
Effects of the putatively oncogenic protein kinase Cα D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias
R Assert et al.
HORMONE AND METABOLIC RESEARCH (2002)
Protein kinase Cδ controls self-antigen-induced B-cell tolerance
I Mecklenbräuker et al.
NATURE (2002)
Translocation of PKC0 in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
M Villalba et al.
JOURNAL OF CELL BIOLOGY (2002)
Missing pieces in the NF-κB puzzle
S Ghosh et al.
CELL (2002)
A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck
DG Pfister et al.
INVESTIGATIONAL NEW DRUGS (2002)
Differential activation of ERKs to focal adhesions by PKC ε is required for PMA-induced adhesion and migration of human glioma cells
A Besson et al.
ONCOGENE (2001)
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
DY Fang et al.
NATURE IMMUNOLOGY (2001)
Constitutive association of c-N-Ras with c-Raf-1 and protein kinase Cε in latent signaling modules
M Hamilton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
AC Newton
CHEMICAL REVIEWS (2001)
Crucial importance of PKC-β(I) in LFA-I-mediated locomotion of activated T cells
Y Volkov et al.
NATURE IMMUNOLOGY (2001)
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms
EA Sausville et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
A phase II trial of bryostatin 1 in patients with non-Hodgkin's lymphoma
FH Blackhall et al.
BRITISH JOURNAL OF CANCER (2001)
Phase II study of bryostatin 1 in patients with relapsed multiple myeloma
ML Varterasian et al.
INVESTIGATIONAL NEW DRUGS (2001)
Protein kinase C θ and ε promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD
C Bertolotto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
ZM Sun et al.
NATURE (2000)
Regulation of protein kinase Cθ function during T cell activation by Lck-mediated tyrosine phosphorylation
YH Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Stable transfection of protein kinase C alpha cDNA in hormone dependent breast cancer cell lines
DA Tonetti et al.
BRITISH JOURNAL OF CANCER (2000)
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