Identification of 5 hub genes for diagnosis of coronary artery disease

Article Multidisciplinary Sciences

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

Ariella T. Cohain et al.

Summary: The study identifies a single genetic regulatory module that influences both cholesterol levels and glucose levels, providing a link between cholesterol levels and diabetes.

NATURE COMMUNICATIONS (2021)

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Editorial Material Biochemistry & Molecular Biology

Recent Trends in Cancer Genomics and Bioinformatics Tools Development

Anastasia A. Anashkina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

Role of mechanical stress and neutrophils in the pathogenesis of plaque erosion

Gregory Franck

Summary: Mechanical stress, particularly shear stress, plays a significant role in plaque erosion, while neutrophil-dependent inflammation may promote plaque erosion via its effects on endothelial cells.

ATHEROSCLEROSIS (2021)

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Article Biochemistry & Molecular Biology

Imbalance in thioredoxin system activates NLRP3 inflammasome pathway in epicardial adipose tissue of patients with coronary artery disease

Hossein Shateri et al.

Summary: The study found significantly higher levels of TXNIP and NLRP3, and decreased levels of TRX-1 in EAT of patients with CAD, leading to a significant increase in IL-1 beta. These results suggest the possible involvement of the thioredoxin system in regulating inflammation in CAD patients.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Cell & Tissue Engineering

GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease

Shun Ouyang et al.

Summary: This study found that the angiogenic capacity of EPCs from CAD patients declined in different pH environments, while EPCs from non-CAD individuals showed enhanced angiogenic capacity in acidic conditions. GPR4 expression in EPCs was significantly lower in CAD patients than in non-CAD individuals, and upregulation of GPR4 promoted neovessel formation in EPCs from CAD patients by activating the STAT3/VEGF signaling pathway.

STEM CELL RESEARCH & THERAPY (2021)

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Article Multidisciplinary Sciences

Pan-cancer classification by regularized multi-task learning

Sk Md Mosaddek Hossain et al.

Summary: This study developed a pan-cancer classification model, PC-RMTL, based on RMTL, which achieved high accuracy in classifying 21 cancer types and adjacent normal samples. Compared with five other state-of-the-art classification algorithms, PC-RMTL outperformed all of them, with SVM-Lin being the closest competitor only when complete feature sets were provided.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Yaqing Zhou et al.

Summary: The study found that proteins closely related to the severity of atherosclerosis, such as PTGS2, ACSL4, caspase-1, and NLRP3, may be associated with ferroptosis and pyroptosis, and involved in the occurrence and development of atherosclerosis. These proteins interact with each other, and PTGS2 may be the central gene in this process.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology