Impact of pre-hospital handling and initial time to cranial computed tomography on outcome in aneurysmal subarachnoid hemorrhage patients with out-of-hospital sudden cardiac arrest-a retrospective bi-centric study

Background: Aneurysmal subarachnoid hemorrhage (SAH) presents occasionally with cardiac arrest (CA). The impact of pre-hospital and emergency room (ER) treatment on outcome remains unclear. Therefore, we investigated the impact of pre-hospital treatment, focusing on lay cardiopulmonary resuscitation (CPR), and ER handling on the outcome of SAH patients with out-of-hospital CA (OHCA). Methods: In this bi-centric retrospective analysis, we reviewed SAH databases for OHCA and CPR from January 2011 to June 2021. Patients were analyzed for general clinical and epidemiological parameters. CPR data were obtained from ambulance reports and information on ER handling from the medical records. Data were correlated with patient survival at hospital discharge as a predefined outcome parameter. Results: Of 1,120 patients with SAH, 45 (4.0%) were identified with OHCA and CPR, 38 of whom provided all required information and were included in this study. Time to resuscitation was significantly shorter with lay resuscitation (5.3 +/- 5.2 min vs. 0.3 +/- 1.2 min, p = 0.003). Nineteen patients were not initially scheduled for cranial computed tomography (CCT), resulting in a significantly longer time interval to first CCT (mean +/- SD: 154 +/- 217 min vs. 40 +/- 23 min; p < 0.001). Overall survival to discharge was 31.6%. Pre-hospital lay CPR was not associated with higher survival (p = 0.632). However, we observed a shorter time to first CCT in surviving patients (p = 0.065) Conclusions: OHCA in SAHpatients is notuncommon. Besides high-quality CPR, time to diagnosis of SAH appears to play an important role. We therefore recommend considering CCT diagnostics as part of the diagnostic algorithm in patients with OHCA.

Automated summary

Cardiac arrest is occasionally seen in patients with aneurysmal subarachnoid hemorrhage (SAH). The impact of pre-hospital and emergency room treatment on SAH patients with out-of-hospital cardiac arrest (OHCA) remains unclear. This study found that time to resuscitation was significantly shorter with lay cardiopulmonary resuscitation (CPR), and delayed cranial computed tomography (CCT) diagnosis was associated with longer time to first CCT. Overall survival to discharge was 31.6%. The study recommends considering CCT diagnostics as part of the diagnostic algorithm in OHCA patients.