Prognostic signature based on mitochondria quality control proteins for the prediction of lung adenocarcinoma patients survival

Article Oncology

Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance

Chuanfen Zhang et al.

Summary: This study found that aberrations in GPX4-induced iron metabolism are correlated with the prognosis of LUAD patients, and inhibition of GPX4 can overcome EGFR-TKI resistance.

TRANSLATIONAL LUNG CANCER RESEARCH (2022)

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Article Multidisciplinary Sciences

Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma

Chao-Yu Liu et al.

Summary: This study evaluated the protein expression of GPX4 in resected NSCLC and found a correlation between GPX4 expression and poor survival outcomes.

SCIENTIFIC REPORTS (2022)

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Article Biochemistry & Molecular Biology

A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease

Ramesh Kandimalla et al.

Summary: The purpose of this study was to investigate the impact of a partial dynamin-related protein 1 (Drp1) on cognitive behavior, mitophagy, autophagy, and mitochondrial and synaptic activities in transgenic Tau mice in Alzheimer's disease (AD). The findings suggest that reducing Drp1 is beneficial in symptomatic transgenic Tau mice.

HUMAN MOLECULAR GENETICS (2022)

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Article Oncology

Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates in Exploitable Vulnerability

Chen-Hua Chuang et al.

Summary: Metastatic lung cancer cells exhibit altered mitochondrial functionality compared to non-metastatic cells, which can be targeted for therapeutic purposes.

CANCER RESEARCH (2021)

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Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitophagy in tumorigenesis and metastasis

Logan P. Poole et al.

Summary: Cells utilize mitophagy to remove dysfunctional or excess mitochondria in response to external stresses, with mechanisms including mitochondrial cargo receptors induced by these stresses, mitochondrial protein targets of PINK1/Parkin phospho-ubiquitination, and mitochondrial lipid signaling. These pathways play a crucial role in tumorigenesis, metastasis, cell cycle control, survival pathways, and therapy responses in cancer. Mitophagy also impacts tissue atrophy during cancer cachexia and clinical therapy responses.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Article Oncology

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis

Yang Cao et al.

Summary: The study found that the expression of SIRT3, FOXO3, and CDT1 was suppressed in lung cancer tissues and cells. Increasing SIRT3 levels can increase the expression of the FOXO3a/CDT1 axis, thereby enhancing the sensitivity of lung cancer cells.

CANCER MEDICINE (2021)

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Article Oncology

Down-regulation of Glutathione Peroxidase 4 in Oral Cancer Inhibits Tumor Growth Through SREBP1 Signaling

Masakatsu Fukuda et al.

Summary: This study investigated the role of GPX4 in the proliferation pathway of oral cancer cells and its protein expression in oral cancer tissues. Knockdown of GPX4 led to reduced cell number in SAS cells, suggesting a potential involvement in non-apoptotic cell death like ferroptosis. Immunopositivity for GPX4 was correlated with p53 immunoreactivity in oral squamous cell carcinoma cells.

ANTICANCER RESEARCH (2021)

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Review Immunology

Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases

Dayene de Assis Fernandes Caldeira et al.

Summary: Mitochondria play crucial roles in chronic lung diseases, and disruptions in mitochondrial function may be central to the pathophysiology of these diseases. Therefore, mitochondrial therapy could serve as a potential therapeutic target for lung diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

SIRT3 acts as a novel biomarker for the diagnosis of lung cancer A retrospective study

Feng Tao et al.

Summary: SIRT3 expression is significantly down-regulated in lung cancer tissues and serum samples, and may serve as a promising biomarker for early diagnosis of lung cancer.

MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Transferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1/PTEN induced kinase 1/acyl-CoA synthetase long chain family member 4 signaling

Lingzhi Zhang et al.

Summary: This study investigated the role of iron metabolism in PCOS and identified the potential therapeutic target of TFRC/NOX1/PINK1/ACSL4 signaling pathway for folliculogenesis.

BIOENGINEERED (2021)

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Review Physiology