Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

Review Immunology

An Emerging Role of TIM3 Expression on T Cells in Chronic Kidney Inflammation

Can Lu et al.

Summary: TIM3 plays a crucial role in immune cell-mediated inflammatory responses and its overexpression has been observed in chronic kidney disease, although clinical evidence is still lacking.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, Research & Experimental

CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain

Susmita K. Singh et al.

Summary: Understanding the internal mechanisms that regulate pain resolution may lead to new treatment targets for chronic pain. The resolution of chemotherapy-induced peripheral neuropathy (CIPN) after treatment completion depends on CD8+ T cells and IL-10 produced by other cells.

JCI INSIGHT (2022)

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Article Medicine, Research & Experimental

Clinical value of the sTim-3 level in chronic kidney disease

Lingli Chen et al.

Summary: Serum sTim-3 levels play an important role in the early diagnosis and monitoring of CKD, and can assist other kidney disease indicators.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Review Urology & Nephrology

Immunopathophysiology of trauma-related acute kidney injury

David A. C. Messerer et al.

Summary: Physical trauma can lead to acute kidney injury, triggered by various causes including hemorrhagic shock, rhabdomyolysis, nephrotoxic drugs, and infectious complications. The complex immunopathophysiological response results in kidney circulatory disturbances, functional impairment, and inflammation, exacerbating multi-organ dysfunction.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Cell Biology

Inhibition of hepatocyte nuclear factor 1β contributes to cisplatin nephrotoxicity via regulation of nf-κb pathway

Yan Zhang et al.

Summary: Cisplatin nephrotoxicity, a serious side effect of cisplatin-based chemotherapy, can be exacerbated by HNF1 beta deficiency, leading to increased renal tubular cell apoptosis. HNF1 beta may ameliorate cisplatin nephrotoxicity by regulating the NF-kappa B signaling pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Urology & Nephrology

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

Sho Hasegawa et al.

Summary: The study found that activating Adrb2 signaling in macrophages induces the expression of Tim3, contributing to anti-inflammatory alterations. In vivo, treatment with salbutamol can block LPS-induced systemic inflammation and protect against renal IRI, with protection being reduced in macrophage-specific Adrb2 cKO mice.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Oncology

The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy

Sashi Kandel et al.

Summary: The blockade of the TIM3/Gal9 pathway shows promising therapeutic potential in cancer treatment, by enhancing immune response and overcoming immune resistance. TIM3 and Gal9 may also serve as prognostic and predictive biomarkers in different types of cancers.

CANCER LETTERS (2021)

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Review Urology & Nephrology

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis

Sophia M. Sears et al.

Summary: The effectiveness of cisplatin, a common drug in treating solid organ cancers, is hindered by its dose-limiting nephrotoxicity. AKI and CKD are closely related, with renal fibrosis being a key feature of CKD development. Understanding the mechanisms behind cisplatin-induced kidney pathologies is crucial for developing effective preventative measures.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Biology

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Shuaijie Dou et al.

Summary: NF90 is a virus sensor that initiates antiviral immunity by triggering SG formation, but its regulation by the Tim-3 pathway results in degradation of NF90 and inhibition of antiviral response. Activation of Tim-3 during VSV infection recruits TRIM47 to degrade NF90, but targeted inactivation of Tim-3 enhances SG formation downstream of NF90 and protects against VSV challenge. These findings provide insight into the crosstalk between Tim-3 and NF90 in antiviral immunity.

ELIFE (2021)

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Article Biochemistry & Molecular Biology

HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study

Gerardo Cazzato et al.

Summary: This study examines skin immunopathology in SARS-CoV-2 positive individuals. Results suggest immune deregulation in those who develop various skin manifestations, with increased activation of HMGB-1 and TIM-3 and decreased expression of Heme oxygenase 1 in the skin samples.

BIOMOLECULES (2021)

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Article Multidisciplinary Sciences

Dual influence of TNFα on diverse in vitro models of ovarian cancer subtypes

Vida Kocbek et al.

Summary: Ovarian cancer, the most lethal gynecological cancer, has various subtypes with distinct risk factors and prognosis. Inflammation through NF kappa B pathway may play a key role in the progression of the disease. The study showed that TNF alpha can have diverse effects on ovarian cancer cells through both NF kappa B and non-NF kappa B pathways.

HELIYON (2021)

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Article Biochemical Research Methods

Preparation and culture of bone marrow-derived macrophages from mice for functional analysis

Gotaro Toda et al.

Summary: This protocol details the collection and differentiation of bone marrow cells into bone marrow-derived macrophages for assessing macrophage function. For more information on the protocol's use and execution, refer to Toda et al. (2020).

STAR PROTOCOLS (2021)

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Article Urology & Nephrology

Protein Kinase C-? Mediates Kidney Tubular Injury in Cold Storage?Associated Kidney Transplantation

Jiefu Zhu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Review Medicine, Research & Experimental

HMGB1 in kidney diseases

Zhi Zhao et al.

LIFE SCIENCES (2020)

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Review Immunology

Inhibitory receptor agonists: the future of autoimmune disease therapeutics?

Stephanie Grebinoski et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

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Review Immunology

TIM3 comes of age as an inhibitory receptor

Yochai Wolf et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Immunology

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

Xianhong Du et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

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Article Oncology

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML

S. Haubner et al.

LEUKEMIA (2019)

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Article Endocrinology & Metabolism

Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

Huimin Yang et al.

MOLECULAR METABOLISM (2019)

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Review Medicine, General & Internal

Acute kidney injury

Claudio Ronco et al.

LANCET (2019)

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Review Oncology

New emerging targets in cancer immunotherapy: the role of TIM3

Alex Friedlaender et al.

ESMO OPEN (2019)

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Review Biochemistry & Molecular Biology

Bax, Bak and beyond - mitochondrial performance in apoptosis

Aida Pena-Blanco et al.

FEBS JOURNAL (2018)

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Article Immunology

Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis

Wei Wang et al.

IMMUNOLOGY (2018)

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Article Immunology

Tim-3 exacerbates kidney ischaemia/reperfusion injury through the TLR-4/NF-B signalling pathway and an NLR-C4 inflammasome activation

Y. Guo et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

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Article Cell Biology

Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE

Di Zhao et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

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Editorial Material Urology & Nephrology

Neutrophils in cisplatin AKI-mediator or marker?

Raghu Tadagavadi et al.

KIDNEY INTERNATIONAL (2017)

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Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Article Biochemistry & Molecular Biology

Tim3/galectin-9 alleviates the inflammation of TAO patients via suppressing Akt/NF-kB signaling pathway

Li-Hua Luo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Toxicology

NF-κB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI)

Abdullah Ozkok et al.

TOXICOLOGY LETTERS (2016)

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Review Pharmacology & Pharmacy

The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases

Qingjie Chen et al.

ACTA PHARMACEUTICA SINICA B (2016)

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Article Physiology

Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity

Qiang Lou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

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Article Immunology

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages

Xingwei Jiang et al.

CLINICAL IMMUNOLOGY (2015)

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Article Medicine, Research & Experimental

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

Xiaorong Zhu et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Immunology

Expression of human T cell immunoglobulin domain and mucin-3 on kidney tissue from immunoglobulin A nephropathy patients

Xiangdong Yang et al.

IMMUNOLOGIC RESEARCH (2014)

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Editorial Material Immunology

Tumor immunity times out: TIM-3 and HMGB1

Daolin Tang et al.

NATURE IMMUNOLOGY (2012)

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Editorial Material Immunology

Balancing pro- and anti-inflammatory TLR4 signaling

Sabine Siegemund et al.

NATURE IMMUNOLOGY (2012)

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Article Pathology

Tim3 Is Upregulated and Protective in Nephrotoxic Serum Nephritis

Andrea Schroll et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Editorial Material Cell Biology

The redox protein HMGB1 regulates cell death and survival in cancer treatment

Daolin Tang et al.

AUTOPHAGY (2010)

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Article Immunology

Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease

Xia Li et al.

CLINICAL IMMUNOLOGY (2010)

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Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

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