Renoprotective Effect of Chrysanthemum coronarium L. Extract on Adenine-Induced Chronic Kidney Disease in Mice

Article Environmental Sciences

Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

Yunping Tang et al.

Science of The Total Environment (2023)

Article Pharmacology & Pharmacy

Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation

Satoyasu Ito et al.

Summary: The study suggests that Juzentaihoto (TJ-48) may exert a renal protective effect in mice with adenine-induced chronic kidney disease by suppressing fibrosis and inflammation.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Article Pharmacology & Pharmacy

Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching

So Ah Kim et al.

Summary: Atherosclerosis is a chronic inflammation caused by interactions between circulating factors and various cell types in blood vessel walls. This study found that TPPU has anti-atherosclerotic effects, potentially by suppressing the phenotype switching of VSMCs.

VASCULAR PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Chrysanthemum coronarium L. Protects against Premature Senescence in Human Endothelial Cells

Mi Jeong Sung et al.

Summary: This study validated the endothelial protective effect of Chrysanthemum coronarium L. (CC) extract and its prevention of cell senescence through the regulation of eNOS and SIRT1 expression.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

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Article Medicine, Research & Experimental

Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats

Moustafa Mahmoud Hamdy et al.

Summary: This study found that nanoforms of furosemide and tadalafil had better renoprotective effects compared with conventional forms in an adenine-induced CRF rat model. The combination of the two drugs using nanoparticle formulations improved urinary, serum, and renal tissue markers of organ damage. The tubular expression of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin was also reduced. Immunohistochemical studies showed that the deteriorated renal cellular changes were greatly improved by the combined treatment, particularly with the nanoforms.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

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Review Integrative & Complementary Medicine

Promoting Plant-Based Therapies for Chronic Kidney Disease

Muhammad Ali Khan et al.

Summary: Chronic kidney disease is a serious global health issue, and current therapies only delay its progression. This review explores the potential of using plant-based therapies to prevent and treat CKD. Many plants have antioxidant properties that can improve kidney function, and pre-clinical and in vivo studies have shown promising therapeutic benefits. Combining plant extracts with conventional therapies may have additive renoprotective effects. Further research is needed to rigorously test and optimize the therapeutic potential of medicinal plants.

JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE (2022)

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Article

Protective effects of lycopene against adenine-induced chronic renal failure in rats

Pooja Gori et al.

Indian Journal of Physiology and Pharmacology (2021)

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Article Medicine, Research & Experimental

Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease

Huiqi Yuan et al.

Summary: TFEB-mediated autophagy plays a crucial role in the pathogenesis of chronic kidney disease, leading to tubulointerstitial injury and renal fibrosis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Immunology

Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling

Mahendra Pal Singh et al.

Summary: Research showed that immunomodulation of cathepsin D (CATD) using morin hydrate (MH) can attenuate kidney fibrosis in chronic kidney disease (CKD), improve kidney function, and enhance survival rates by nearly 150% compared to untreated mice.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Lindera aggregata intervents adenine-induced chronic kidney disease by mediating metabolism and TGF-β/Smad signaling pathway

Hongdie Cai et al.

Summary: Comparative studies have shown that Lindera aggregata extracts exhibit significant effects in inhibiting the rebound of indicators in chronic kidney disease models and alleviating renal tissue pathological damage. Metabolic profile analysis revealed that various metabolites related to CKD gradually returned to normal levels after intervention with Lindera aggregata extracts.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell Biology

Metformin Attenuates Renal Fibrosis in a Mouse Model of Adenine-Induced Renal Injury Through Inhibiting TGF-β1 Signaling Pathways

Hao Yi et al.

Summary: This study found that metformin can attenuate adenine-induced renal fibrosis through inhibition of the TGF-beta 1 signaling pathways and activation of AMPK, independent of its glucose-lowering action.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Integrative & Complementary Medicine

The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

Christelle Stephanie Sonfack et al.

Summary: The study evaluated the cardioprotective and nephroprotective effects of the aqueous extract from the stem bark of Garcinia lucida, known for its antioxidant properties. The extract showed potent antioxidant activity and reduced adverse effects induced by adenine in a chronic kidney disease model, indicating its potential as a therapeutic agent for cardiovascular and renal diseases.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Caffeic Acid, One of the Major Phenolic Acids of the Medicinal Plant Antirhea borbonica, Reduces Renal Tubulointerstitial Fibrosis

Bryan Veeren et al.

Summary: The study shows that the polyphenol-rich extract from A. borbonica, as well as CA, can significantly improve renal tubulointerstitial fibrosis progression in the UUO mouse model through reducing macrophage infiltration, myofibroblast appearance, and extracellular matrix accumulation. Additionally, this effect is associated with the down-regulation of Tgf-beta, Tnf-alpha, Mcp1 and NfkB, as well as the upregulation of Nrf2, and an increased antioxidant enzyme activity for GPX and Cu/ZnSOD.

BIOMEDICINES (2021)

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Article Integrative & Complementary Medicine