Related references
Note: Only part of the references are listed.Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents
Silvia Salerno et al.
MOLECULES (2023)
Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. In vitro antiviral activity evaluation against Zika and Dengue viruses
Maria del Rosario Garcia-Lozano et al.
BIOORGANIC CHEMISTRY (2023)
Synthesis and cytotoxicity evaluation of DNA-interactive beta-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies
Jay Prakash Soni et al.
BIOORGANIC CHEMISTRY (2023)
The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein
Elisa Angeloni et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2023)
Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis
Chiara Tremolanti et al.
MOLECULAR NEUROBIOLOGY (2022)
BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways
Jyh-Der Leu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Epidemiology of Insomnia Prevalence, Course, Risk Factors, and Public Health Burden
Charles M. Morin et al.
SLEEP MEDICINE CLINICS (2022)
Targeting TSPO Reduces Inflammation and Apoptosis in an In Vitro Photoreceptor-Like Model of Retinal Degeneration
Francesca Corsi et al.
ACS CHEMICAL NEUROSCIENCE (2022)
An update into the medicinal chemistry of translocator protein (TSPO) ligands
Elisabetta Barresi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Cellular sources of TSPO expression in healthy and diseased brain
Erik Nutma et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)
Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters
Elisabetta Barresi et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
Targeting metastatic cancer
Karuna Ganesh et al.
NATURE MEDICINE (2021)
Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease
Shenyou Nie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Recent trends in cancer therapy: A review on the current state of gene delivery
Esam Bashir Yahya et al.
LIFE SCIENCES (2021)
De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein
Lorenzo Germelli et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
Marco Robello et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Cinnamic acid inhibits Zika virus by inhibiting RdRp activity
Yuting Chen et al.
ANTIVIRAL RESEARCH (2021)
Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp
Jianyuan Zhao et al.
ACS INFECTIOUS DISEASES (2021)
Carbonic anhydrase activation profile of indole-based derivatives
Elisabetta Barresi et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties
Elisabetta Barresi et al.
DALTON TRANSACTIONS (2021)
Design, synthesis and discovery of andrographolide derivatives against Zika virus infection
Feng Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Mechanisms of Multidrug Resistance in Cancer Chemotherapy
Karol Bukowski et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases
Jonathan E. Phillips
FRONTIERS IN PHARMACOLOGY (2020)
Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets
Sabrina Taliani et al.
MOLECULES (2020)
Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection
Michael Kozal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Cinnamic Acid Derivatives and Their Biological Efficacy
Ngonidzashe Ruwizhi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Structure-activity relationships in a series of auranofin analogues showing remarkable antiproliferative properties
Ida Landini et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2020)
Synthesis and biological evaluation of indolylglyoxylamide bisphosphonates, antimitotic microtubule-targeting derivatives of indibulin with improved aqueous solubility
Valery K. Brel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
A mixed-valence diruthenium(II,III) complex endowed with high stability: from experimental evidence to theoretical interpretation
Elisabetta Barresi et al.
DALTON TRANSACTIONS (2020)
Indole - a promising pharmacophore in recent antiviral drug discovery
Atukuri Dorababu
RSC MEDICINAL CHEMISTRY (2020)
6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers
Steven A. Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations
Agostino Bruno et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties
Rui Wang et al.
BIOORGANIC CHEMISTRY (2019)
Synthesis and in vitro cytotoxicity evaluation of β-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topoisomerase-II inhibition
Chetna Jadala et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference
Sara Charmsaz et al.
CANCERS (2019)
Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2
Shewei Guo et al.
LIFE SCIENCES (2019)
Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines
Melissa M. Cadelis et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir
Nicholas A. Meanwell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
A quinoline compound inhibits the replication of dengue virus serotypes 1-4 in Vero cells
Hemalatha Beesetti et al.
ANTIVIRAL THERAPY (2018)
Translocator protein and steroidogenesis
Barbara Costa et al.
BIOCHEMICAL JOURNAL (2018)
Design and Synthesis of DNA-Interactive -Carboline-Oxindole Hybrids as Cytotoxic and Apoptosis-Inducing Agents
Ramya Tokala et al.
CHEMMEDCHEM (2018)
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds
Suzanne J. F. Kaptein et al.
CHEMMEDCHEM (2018)
The side effects of platinum-based chemotherapy drugs: a review for chemists
Rabbab Oun et al.
DALTON TRANSACTIONS (2018)
Carbonic anhydrase activators
Claudiu T. Supuran
FUTURE MEDICINAL CHEMISTRY (2018)
Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2
Carolina de la Guardia et al.
MOLECULES (2018)
GABA(A) receptor: Positive and negative allosteric modulators
Richard W. Olsen
NEUROPHARMACOLOGY (2018)
The Benzodiazepine Binding Sites of GABAA Receptors
Erwin Sigel et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts
Massinissa Si Mehand et al.
ANTIVIRAL RESEARCH (2018)
Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
Sravanthi Devi Guggilapu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine
Giselle Barbosa-Limaa et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
Sravanthi Devi Guggilapu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)nicotinamides
Andreas Kling et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
Marie Pancera et al.
NATURE CHEMICAL BIOLOGY (2017)
Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus
Anuradha Balasubramanian et al.
ANTIVIRAL RESEARCH (2017)
Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress
Ryota Amano et al.
ANTIVIRAL RESEARCH (2017)
Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities
Mukund P. Tantak et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
Timothy C. Johnstone et al.
CHEMICAL REVIEWS (2016)
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis
Anna Santoro et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas
Simona Daniele et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells
Simona Daniele et al.
ONCOTARGET (2016)
Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents
Venkataramana P. O. Reddy et al.
RSC ADVANCES (2016)
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
Barbara Costa et al.
SCIENTIFIC REPORTS (2016)
TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being
Eleonora Da Pozzo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities
Mukund P. Tantak et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors
Michael Juchum et al.
DRUG RESISTANCE UPDATES (2015)
Cinnamic Acid and Cinnamaldehyde Ameliorate Cisplatin-Induced Splenotoxicity in Rats
Ola M. Abd El-Raouf et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2015)
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides
Elisabetta Barresi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer
Helen E. Colley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Novel Dengue Virus NS2B/NS3 Protease Inhibitors
Hongmei Wu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Development of photodynamic therapy regimens that control primary tumor growth and inhibit secondary disease
Madeeha Shams et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)
Allosteric modulators of human A2B adenosine receptor
Maria Letizia Trincavelli et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators
Maria Letizia Trincavelli et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia
Tori A. Matthews et al.
BRAIN RESEARCH (2014)
Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis
Kanako Morohaku et al.
ENDOCRINOLOGY (2014)
Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome The VISTA-16 Randomized Clinical Trial
Stephen J. Nicholls et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis
Lan N. Tu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
New Ianthelliformisamine Derivatives as Antibiotic Enhancers against Resistant Gram-Negative Bacteria
Cyril Pieri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Synthesis and biological activity of novel bis-indole inhibitors of bacterial transcription initiation complex formation
Marcin Mielczarek et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Correction: Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis
Ajay Singh et al.
PLoS One (2014)
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
Simona Daniele et al.
SCIENTIFIC REPORTS (2014)
BPR0C305, an orally active microtubule-disrupting anticancer agent
Wen-Tai Li et al.
ANTI-CANCER DRUGS (2013)
Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures
Eva Ruusuvuori et al.
EMBO JOURNAL (2013)
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives
Sabrina Taliani et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease
Christoph Nitsche et al.
ANTIVIRAL RESEARCH (2012)
Recent Developments in Potential Anxiolytic Agents Targeting GABAA/BzR Complex or the Translocator Protein (18kDa) (TSPO)
Caroline Nothdurfter et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping
Jing Deng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Translocator Protein (18 kDa) as a Target for Novel Anxiolytics with a Favourable Side-Effect Profile
C. Nothdurfter et al.
JOURNAL OF NEUROENDOCRINOLOGY (2012)
Anxioselective anxiolytics: on a quest for the Holy Grail
Phil Skolnick
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Antiviral Activity, Pharmacokinetics, and Safety of BMS-488043, a Novel Oral Small-Molecule HIV-1 Attachment Inhibitor, in HIV-1-Infected Subjects
George J. Hanna et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture
Christian Steuer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases
Christoph Nitsche et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Synthesis and evaluation of indole-based new scaffolds for antimicrobial activities-Identification of promising candidates
Palwinder Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities
Chih-Bo Hu et al.
CANCER SCIENCE (2011)
Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
Edward A. Dennis et al.
CHEMICAL REVIEWS (2011)
Structure-Activity Relationship Refinement and Further Assessment of Indole-3-glyoxylamides as a Lead Series against Prion Disease
Mark J. Thompson et al.
CHEMMEDCHEM (2011)
Designed Multiple Ligands for Cancer Therapy
N. M. O'Boyle et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
Mark J. Thompson et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis
Mark C. Genovese et al.
JOURNAL OF RHEUMATOLOGY (2011)
Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme
Ruth Villalonga-Planells et al.
PLOS ONE (2011)
Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells
Yun-Ju Chen et al.
PLOS ONE (2011)
Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity
Barbara Costa et al.
PSYCHONEUROENDOCRINOLOGY (2011)
Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents
Shikha S. Chauhan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-β-carbolines as antileishmanial agents
Ravi Kumar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Varespladib methyl in cardiovascular disease
Robert S. Rosenson et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors
R. L. Oostendorp et al.
INVESTIGATIONAL NEW DRUGS (2010)
Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns
Nicholas A. Meanwell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives
Tao Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity
Nicholas A. Meanwell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Metal complexes involving indole rings: Structures and effects of metal-indole interactions
Yuichi Shimazaki et al.
COORDINATION CHEMISTRY REVIEWS (2009)
Translocator Protein Ligands as Promising Therapeutic Tools for Anxiety Disorders
S. Taliani et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABAA) α2 Benzodiazepine Receptor
Sabrina Taliani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects
Tao Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Design, Synthesis, and Structure-Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease
Mark J. Thompson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders
David M. Goldstein et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
From Nature to Drug Discovery: The Indole Scaffold as a 'Privileged Structure'
Fernando Rodrigues de Sa Alves et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a phase II double-blind, randomised, placebo-controlled trial
Robert S. Rosenson et al.
LANCET (2009)
HIV Entry Inhibitors and Their Potential in HIV Therapy
Keduo Qian et al.
MEDICINAL RESEARCH REVIEWS (2009)
Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector
Natalia S. Akopyants et al.
SCIENCE (2009)
Proteophosophoglycans Regurgitated by Leishmania-Infected Sand Flies Target the L-Arginine Metabolism of Host Macrophages to Promote Parasite Survival
Matthew Rogers et al.
PLOS PATHOGENS (2009)
How Antirheumatic Drugs Protect Joints From Damage in Rheumatoid Arthritis
Georg Schett et al.
ARTHRITIS AND RHEUMATISM (2008)
Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents
Mohamed Takhi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Post-bedtime dosing with indiplon in adults and the elderly: results from two placebo-controlled, active comparator crossover studies in healthy volunteers
Robert H. Farber et al.
CURRENT MEDICAL RESEARCH AND OPINION (2008)
Anxiolytic-like effects of N,N-Dialkyl-2-phenylindol-3-ylgiyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
Federico Da Settimo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity
Ronald J. Hill et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Prion proteins:: Physiological functions and role in neurological disorders
Wei Hu et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
NATURE REVIEWS DRUG DISCOVERY (2008)
The 18-kDa translocator protein, formerly known as the peripheral-type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line
Rami Shoukrun et al.
PHARMACOGENETICS AND GENOMICS (2008)
The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
G. Schett et al.
ANNALS OF THE RHEUMATIC DISEASES (2008)
Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents
Leena Gupta et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors
I. E. L. M. Kuppens et al.
INVESTIGATIONAL NEW DRUGS (2007)
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands
Giampaolo Primofiore et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
p38 pathway kinases as anti-inflammatory drug targets
J. F. Schindler et al.
JOURNAL OF DENTAL RESEARCH (2007)
GABA(A)/Bz receptor subtypes as targets for selective drugs
F. Da Settimo et al.
CURRENT MEDICINAL CHEMISTRY (2007)
P38 mitogen-activated protein kinase (MAPK) in rheumatoid arthritis
J. Westra et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Efficacy and safety of zolpidem-MR: A double-blind, placebo-controlled study in adults with primary insomnia
Thomas Roth et al.
SLEEP MEDICINE (2006)
Translocator protein (18 kDa):: new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
Vassilios Papadopoulos et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides
G Primofiore et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events
HT Ho et al.
JOURNAL OF VIROLOGY (2006)
A pyrimidine-β-carboline and other alkaloids from Annona foetida with antileishmanial activity
EV Costa et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders
V Papadopoulos et al.
NEUROSCIENCE (2006)
Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis
Adelheid Korb et al.
ARTHRITIS AND RHEUMATISM (2006)
Syntheses of new substituted triazino tetrahydroisoquinolines and beta-carbolines as novel antileishmanial agents
A Kumar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2006)
Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics
Z Yang et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2005)
The global status of resistance to antiretroviral drugs
S Vella et al.
CLINICAL INFECTIOUS DISEASES (2005)
BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo
Y Kuma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics
JR Atack
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2005)
Cellular processing of platinum anticancer drugs
D Wang et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthma
DL Bowton et al.
JOURNAL OF ASTHMA (2005)
Benefit-risk assessment of zaleplon in the treatment of insomnia
J Barbera et al.
DRUG SAFETY (2005)
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides.: A new class of potent and selective ligands at the peripheral benzodiazepine receptor
G Primofiore et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Recognition of privileged structures by G-protein coupled receptors
K Bondensgaard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Synthesis of BILN 2061, an HCVNS3 protease inhibitor with proven antiviral effect in humans
AM Faucher et al.
ORGANIC LETTERS (2004)
In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
H Kuss et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]lpyridin-3-yl)oxoacetyl]-2-(R)-methylpiperazine (BMS-378806):: A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions
T Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
PF Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents
WT Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure
E Abraham et al.
CRITICAL CARE MEDICINE (2003)
The mouse light/dark box test
M Bourin et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Sustained efficacy of eszopiclone over 6 months of nightly treatment: Results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia
AD Krystal et al.
SLEEP (2003)
Anxioselective Compounds Acting at the GABA(A) Receptor Benzodiazepine Binding Site
John R. Atack
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2003)
New drugs for insomnia - Comparative tolerability of zopiclone, zolpidem and zaleplon
MG Terzano et al.
DRUG SAFETY (2003)
Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit
AP Johnson et al.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2002)
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis et al.
NATURE STRUCTURAL BIOLOGY (2002)
Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs
C Burnouf et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
A new benzodiazepine pharmacology
H Mohler et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids
D Marx et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2002)
Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study
CH Compton et al.
LANCET (2001)
4-hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters
SE Hagen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Novel N-(arylalkyl) indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor:: Synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships
G Primofiore et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Taxanes in combined modality therapy for solid tumors
H Choy
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2001)
Share Paper
