Indol-3-ylglyoxylamide as Privileged Scaffold in Medicinal Chemistry

In recent years, indolylglyoxylamide-based derivatives have received much attention due to their application in drug design and discovery, leading to the development of a wide array of compounds that have shown a variety of pharmacological activities. Combining the indole nucleus, already validated as a privileged structure, with the glyoxylamide function allowed for an excellent template to be obtained that is suitable to a great number of structural modifications aimed at permitting interaction with specific molecular targets and producing desirable therapeutic effects. The present review provides insight into how medicinal chemists have elegantly exploited the indolylglyoxylamide moiety to obtain potentially useful drugs, with a particular focus on compounds exhibiting activity in in vivo models or reaching clinical trials. All in all, this information provides exciting new perspectives on existing data that can be useful in further design of indolylglyoxylamide-based molecules with interesting pharmacological profiles. The aim of this report is to present an update of collection data dealing with the employment of this moiety in the rational design of compounds that are able to interact with a specific target, referring to the last 20 years.

Automated summary

In recent years, indolylglyoxylamide-based derivatives have been extensively studied for their potential in drug design and discovery, resulting in a wide range of compounds with diverse pharmacological activities. This review focuses on the elegant utilization of the indolylglyoxylamide moiety by medicinal chemists to develop potential drugs, particularly those showing in vivo activity or undergoing clinical trials. The information provided in this review offers valuable insights and perspectives for further research and design of indolylglyoxylamide-based molecules with promising pharmacological profiles.