Journal
PHARMACEUTICALS
Volume 16, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ph16081093
Keywords
nutrigenomics; antimicrobial resistance; novel antibiotics; gut microbiome
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Nutrigenomics studies the impact of diets or nutrients on gene expression and phenotypes through high-throughput technologies, such as transcriptomics, proteomics, and metabolomics. The bioactive components of diets and nutrients transmit information through altered gene expression, affecting the overall function and traits of an organism. Recent evidence suggests a correlation between gene regulation and antibiotic resistance in response to diets and nutrients, providing a potential alternative solution against antibiotic resistance. However, little progress has been made in this area.
Nutrigenomics is the study of the impact of diets or nutrients on gene expression and phenotypes using high-throughput technologies such as transcriptomics, proteomics, metabolomics, etc. The bioactive components of diets and nutrients, as an environmental factor, transmit information through altered gene expression and hence the overall function and traits of the organism. Dietary components and nutrients not only serve as a source of energy but also, through their interactions with genes, regulate gut microbiome composition, the production of metabolites, various biological processes, and finally, health and disease. Antimicrobial resistance in pathogenic and probiotic microorganisms has emerged as a major public health concern due to the presence of antimicrobial resistance genes in various food products. Recent evidence suggests a correlation between the regulation of genes and two-component and other signaling systems that drive antibiotic resistance in response to diets and nutrients. Therefore, diets and nutrients may be alternatively used to overcome antibiotic resistance against novel antibiotics. However, little progress has been made in this direction. In this review, we discuss the possible implementations of nutrigenomics in antibiotic resistance against novel antibiotics.
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