Related references
Note: Only part of the references are listed.Insulitis and -Cell Mass in the Natural History of Type 1 Diabetes
Martha Campbell-Thompson et al.
DIABETES (2016)
Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine
Enagnon Kazali Alidjinou et al.
ANTIVIRAL RESEARCH (2015)
The gut microbiota and Type 1 Diabetes
Elke Guelden et al.
CLINICAL IMMUNOLOGY (2015)
TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
Laura Marroqui et al.
DIABETES (2015)
Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study
Lars Krogvold et al.
DIABETES (2015)
Reduced Expression of the MDA5 Gene IFIH1 Prevents Autoimmune Diabetes
Pamela J. Lincez et al.
DIABETES (2015)
Current Concepts on the Pathogenesis of Type 1 Diabetes-Considerations for Attempts to Prevent and Reverse the Disease
Mark A. Atkinson et al.
DIABETES CARE (2015)
Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes
Jessica A. Pane et al.
DIABETOLOGIA (2015)
The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
Jeffrey P. Krischer et al.
DIABETOLOGIA (2015)
Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease
Johanna Lempainen et al.
JOURNAL OF AUTOIMMUNITY (2015)
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
Suna Onengut-Gumuscu et al.
NATURE GENETICS (2015)
Early IFN type I response: Larning from microbial evasion strategies
Eliana M. Coccia et al.
SEMINARS IN IMMUNOLOGY (2015)
Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis
Jon Sin et al.
VIROLOGY (2015)
Interferon therapy in hepatitis C leading to chronic type 1 diabetes
Taiba Zornitzki et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2015)
Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes
Kenichi Izumi et al.
NATURE COMMUNICATIONS (2015)
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells
Laura Marroqui et al.
ELIFE (2015)
TYK2 Promoter Variant and Diabetes Mellitus in the Japanese
Seiho Nagafuchi et al.
EBIOMEDICINE (2015)
Pancreatic α Cells are Resistant toMetabolic Stress-induced Apoptosis in Type 2 Diabetes
Laura Marroqui et al.
EBIOMEDICINE (2015)
Viral Infection of Engrafted Human Islets Leads to Diabetes
Glen R. Gallagher et al.
DIABETES (2015)
Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes
Lars Krogvold et al.
DIABETES (2015)
A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models
Par G. Larsson et al.
DIABETOLOGIA (2015)
Coxsackievirus can Persist in Murine Pancreas by Deletion of 5′ Terminal Genomic Sequences
Steven Tracy et al.
JOURNAL OF MEDICAL VIROLOGY (2015)
Genetic and epigenetic fine mapping of causal autoimmune disease variants
Kyle Kai-How Farh et al.
NATURE (2015)
Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine
Kristen M. Drescher et al.
REVIEWS IN MEDICAL VIROLOGY (2015)
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion
Ezio Bonifacio et al.
ACTA DIABETOLOGICA (2014)
Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Hong Sheng Quah et al.
DIABETES (2014)
RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
Miriam Cnop et al.
DIABETES (2014)
Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Sami Oikarinen et al.
DIABETES (2014)
Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes
Olli H. Laitinen et al.
DIABETES (2014)
BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2
Laura Marroqui et al.
DIABETES (2014)
Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families
Yi-Guang Chen et al.
DIABETES (2014)
A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
Ricardo C. Ferreira et al.
DIABETES (2014)
Potential viral pathogenic mechanism in human type 1 diabetes
Darius A. Schneider et al.
DIABETOLOGIA (2014)
Pancreatic Pathology in Type 1 Diabetes Mellitus
Sarah J. Richardson et al.
ENDOCRINE PATHOLOGY (2014)
Developing a vaccine for Type 1 diabetes through targeting enteroviral infections
Heikki Hyoty et al.
EXPERT REVIEW OF VACCINES (2014)
Role of Viruses and Other Microbes in the Pathogenesis of Type 1 Diabetes
Anita Kondrashova et al.
INTERNATIONAL REVIEWS OF IMMUNOLOGY (2014)
Infection of Human Islets of Langerhans With Two Strains of Coxsackie B Virus Serotype 1: Assessment of Virus Replication, Degree of Cell Death and Induction of Genes Involved in the Innate Immunity Pathway
Mahesh Anagandula et al.
JOURNAL OF MEDICAL VIROLOGY (2014)
Ditch the term pathogen
Arturo Casadevall et al.
NATURE (2014)
CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
Tina Floyel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?
Noel G. Morgan et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)
Innate antiviral signalling in the central nervous system
Michael Carty et al.
TRENDS IN IMMUNOLOGY (2014)
The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland
Anita Kondrashova et al.
APMIS (2013)
Prevention or acceleration of type 1 diabetes by viruses
Liana Ghazarian et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Jorma Ilonen et al.
DIABETES (2013)
Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis
I. Santin et al.
DIABETES OBESITY & METABOLISM (2013)
Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
S. J. Richardson et al.
DIABETOLOGIA (2013)
Pathophysiological mechanisms involving aggressive islet cell destruction in fulminant type 1 diabetes
Shoichiro Tanaka et al.
ENDOCRINE JOURNAL (2013)
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette G. Ziegler et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)
Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes
Sylvie Chabot et al.
JOURNAL OF AUTOIMMUNITY (2013)
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
Julien Diana et al.
NATURE MEDICINE (2013)
Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses
Hyelim Cho et al.
NATURE MEDICINE (2013)
Evidence of Association between Type 1 Diabetes and Exposure to Enterovirus in Cuban Children and Adolescents
Luis Sarmiento et al.
MEDICC REVIEW (2013)
Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens
Felix Randow et al.
SCIENCE (2013)
GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
Tatiane C. Nogueira et al.
PLOS GENETICS (2013)
Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Regine Bergholdt et al.
DIABETES (2012)
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Ken T. Coppieters et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis
I. Santin et al.
CELL DEATH & DISEASE (2012)
The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes
Jean-Francois Bach et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
Decio L. Eizirik et al.
PLOS GENETICS (2012)
An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes
Christiane Winkler et al.
DIABETES (2011)
PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
Izortze Santin et al.
DIABETES (2011)
Type 1 Diabetes and Interferon Therapy A nationwide survey in Japan
Kan Nakamura et al.
DIABETES CARE (2011)
Fulminant type 1 diabetes - an important subtype in East Asia
Akihisa Imagawa et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2011)
Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes
A. Willcox et al.
DIABETOLOGIA (2011)
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
S. A. Long et al.
GENES AND IMMUNITY (2011)
A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes
Laura Espino-Paisan et al.
IMMUNOGENETICS (2011)
Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases
Jin-Hui Tao et al.
MOLECULAR BIOLOGY REPORTS (2011)
Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
Esteban N. Gurzov et al.
TRENDS IN CELL BIOLOGY (2011)
Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci
Alexandra Zhernakova et al.
PLOS GENETICS (2011)
Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies
Wing-Chi G. Yeung et al.
BMJ-BRITISH MEDICAL JOURNAL (2011)
Genetics of Type 1 Diabetes: What's Next?
Flemming Pociot et al.
DIABETES (2010)
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
M. Cnop et al.
DIABETOLOGIA (2010)
Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis
F. Reynier et al.
GENES AND IMMUNITY (2010)
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA
Maikel L. Colli et al.
HUMAN MOLECULAR GENETICS (2010)
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Matthias Heinig et al.
NATURE (2010)
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Fabrizio Thorel et al.
NATURE (2010)
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
Chris Wallace et al.
NATURE GENETICS (2010)
Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
Didier Hober et al.
NATURE REVIEWS ENDOCRINOLOGY (2010)
Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes
Kate Downes et al.
PLOS ONE (2010)
Detection of Enterovirus RNA in Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients Beyond the Stage of Acute Infection
Barbara M. Schulte et al.
VIRAL IMMUNOLOGY (2010)
Immune cell crosstalk in type 1 diabetes
Agnes Lehuen et al.
NATURE REVIEWS IMMUNOLOGY (2010)
PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ-Induced Pancreatic β-Cell Apoptosis
Fabrice Moore et al.
DIABETES (2009)
The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes
S. J. Richardson et al.
DIABETOLOGIA (2009)
Review series on helminths, immune modulation and the hygiene hypothesis: How might infection modulate the onset of type 1 diabetes?
Anne Cooke
IMMUNOLOGY (2009)
Antiviral Effect of Nicotinamide on Enterovirus-Infected Human Islets In Vitro: Effect on Virus Replication and Chemokine Secretion
Annika Moell et al.
JOURNAL OF MEDICAL VIROLOGY (2009)
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
Christopher C. Patterson et al.
LANCET (2009)
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
Decio L. Eizirik et al.
NATURE REVIEWS ENDOCRINOLOGY (2009)
Genetics of Type 1A Diabetes
Patrick Concannon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
Sergey Nejentsev et al.
SCIENCE (2009)
MDA5/RIG-I and virus recognition
Osamu Takeuchi et al.
CURRENT OPINION IN IMMUNOLOGY (2008)
Analysis of pancreas tissue in a child positive for islet cell antibodies
M. Oikarinen et al.
DIABETOLOGIA (2008)
Selective Inhibitors of Picornavirus Replication
Armando M. De Palma et al.
MEDICINAL RESEARCH REVIEWS (2008)
Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
Deborah J. Smyth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Concordance for Islet Autoimmunity among Monozygotic Twins
Maria J. Redondo et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Interferon-α initiates type 1 diabetes in nonobese diabetic mice
Qing Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis
A. E. Butler et al.
DIABETOLOGIA (2007)
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets
Anna-Karin Berg et al.
ANTIVIRAL RESEARCH (2007)
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
Francesco Dotta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mechanisms of the hygiene hypothesis - molecular and otherwise
Donata Vercelli
CURRENT OPINION IN IMMUNOLOGY (2006)
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?
JJ Meier et al.
DIABETOLOGIA (2005)
Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection
T Kamradt et al.
TRENDS IN IMMUNOLOGY (2005)
Diabetes acceleration or prevention by a coxsackievirus B4 infection: Critical requirements for both interleukin-4 and gamma interferon
DV Serreze et al.
JOURNAL OF VIROLOGY (2005)
Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells
P Ylipaasto et al.
DIABETOLOGIA (2004)
Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection
KM Drescher et al.
VIROLOGY (2004)
Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient
U Christen et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes
U Christen et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells
AY Savinov et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Target cell defense prevents the development of diabetes after viral infection
M Flodström et al.
NATURE IMMUNOLOGY (2002)
A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis
DL Eizirik et al.
DIABETOLOGIA (2001)
Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to coxsackie or proinsulin peptides do not crossreact with homologous counterpart
NC Schloot et al.
HUMAN IMMUNOLOGY (2001)
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase
HS Hiemstra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in β cells
W Chehadeh et al.
JOURNAL OF VIROLOGY (2000)
Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets
DV Serreze et al.
DIABETES (2000)