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PLOS ONE (2013)
Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice
Elise F. Hoek-van den Hil et al.
PLOS ONE (2013)
Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice
Jingbo Pang et al.
PLOS ONE (2013)
Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis
Laura J. Dixon et al.
PLOS ONE (2013)
LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
Andrew C. Adams et al.
PLOS ONE (2013)
Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis
Petra Hirsova et al.
PLOS ONE (2013)
Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors
Peter G. Traber et al.
PLOS ONE (2013)
Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease
Peter G. Traber et al.
PLOS ONE (2013)
Increased Adiposity in Annexin A1-Deficient Mice
Rand T. Akasheh et al.
PLOS ONE (2013)
Identification of Three Novel Natural Product Compounds that Activate PXR and CAR and Inhibit Inflammation
Suticha Kittayaruksakul et al.
PHARMACEUTICAL RESEARCH (2013)
Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles
Nazila Kamaly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
Giovanni Musso et al.
PROGRESS IN LIPID RESEARCH (2013)
Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs
Tony Velkov
PPAR RESEARCH (2013)
Nrf2 Activators Attenuate the Progression of Nonalcoholic Steatohepatitis-Related Fibrosis in a Dietary Rat Model
Rieko Shimozono et al.
MOLECULAR PHARMACOLOGY (2013)
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
Kouichi Miura et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)
Myeloid Deletion of Nuclear Factor Erythroid 2-Related Factor 2 Increases Atherosclerosis and Liver Injury
Alan R. Collins et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress
S. Gomez-Zorita et al.
BRITISH JOURNAL OF NUTRITION (2012)
Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice
Su-Jung Cho et al.
BRITISH JOURNAL OF NUTRITION (2012)
Mir-33 regulates cell proliferation and cell cycle progression
Daniel Cirera-Salinas et al.
CELL CYCLE (2012)
Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
Hae-Ki Min et al.
CELL METABOLISM (2012)
Increased Macrophage Migration Into Adipose Tissue in Obese Mice
Da Young Oh et al.
DIABETES (2012)
Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
G. Musso et al.
DIABETOLOGIA (2012)
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
Chang Joo Oh et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis
Vlad Ratziu et al.
HEPATOLOGY (2012)
S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver
KyeongJin Kim et al.
HEPATOLOGY (2012)
The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani et al.
HEPATOLOGY (2012)
Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
Minsheng Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production
Annie-Carole Tosello-Trampont et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat
Joan Claria et al.
JOURNAL OF IMMUNOLOGY (2012)
Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
Sorina Georgiana Boaru et al.
JOURNAL OF INFLAMMATION-LONDON (2012)
Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis
Juliana P. Vago et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2012)
Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats
Sunil K. Panchal et al.
JOURNAL OF NUTRITION (2012)
Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
Andrew C. Adams et al.
PLOS ONE (2012)
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
Randy Hecht et al.
PLOS ONE (2012)
Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats
Pankaj K. Bagul et al.
PHARMACOLOGICAL RESEARCH (2012)
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Tatiana Kisseleva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
Ian N. Foltz et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor
Guodong Li et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Acetylation of pregnane X receptor protein determines selective function independent of ligand activation
Arunima Biswas et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Role of S6K1 in regulation of SREBP1c expression in the liver
Shuying Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Timothy R. Peterson et al.
CELL (2011)
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers et al.
CELL METABOLISM (2011)
Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus
Guido T. Bommer et al.
CELL METABOLISM (2011)
Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice
Z. Yu et al.
DIABETOLOGIA (2011)
MBX-8025, A Novel Peroxisome Proliferator Receptor-δ Agonist: Lipid and Other Metabolic Effects in Dyslipidemic Overweight Patients Treated with and without Atorvastatin
Harold E. Bays et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
William L. Holland et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver
Carla Iacobini et al.
JOURNAL OF HEPATOLOGY (2011)
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes
Charles A. Harris et al.
JOURNAL OF LIPID RESEARCH (2011)
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
William L. Holland et al.
NATURE MEDICINE (2011)
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Bolormaa Vandanmagsar et al.
NATURE MEDICINE (2011)
The Human Serum Metabolome
Nikolaos Psychogios et al.
PLOS ONE (2011)
Increased Diacylglycerols Characterize Hepatic Lipid Changes in Progression of Human Nonalcoholic Fatty Liver Disease; Comparison to a Murine Model
D. Lee Gorden et al.
PLOS ONE (2011)
Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer
George M. Philips et al.
PLOS ONE (2011)
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Alberto Davalos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
Francois R. Jornayvaz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Cellular senescence controls fibrosis in wound healing
Joon-Il Jun et al.
AGING-US (2010)
Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis
Anna Moles et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Emerging Molecular Targets for the Treatment of Nonalcoholic Fatty Liver Disease
Giovanni Musso et al.
ANNUAL REVIEW OF MEDICINE (2010)
Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
Wan Huang et al.
DIABETES (2010)
Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
Anil Kumar et al.
DIABETES (2010)
C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis
Amrom E. Obstfeld et al.
DIABETES (2010)
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
Ffolliott M. Fisher et al.
DIABETES (2010)
Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease
Rhiannon N. Hardwick et al.
DRUG METABOLISM AND DISPOSITION (2010)
Accumulation of Natural Killer T Cells in Progressive Nonalcoholic Fatty Liver Disease
Wing-Kin Syn et al.
HEPATOLOGY (2010)
Activation of Rac1 Promotes Hedgehog-Mediated Acquisition of the Myofibroblastic Phenotype in Rat and Human Hepatic Stellate Cells
Steve S. Choi et al.
HEPATOLOGY (2010)
The Fractalkine Receptor CX3CR1 Protects Against Liver Fibrosis by Controlling Differentiation and Survival of Infiltrating Hepatic Monocytes
Karlin Raja Karlmark et al.
HEPATOLOGY (2010)
5-Lipoxygenase Deficiency Reduces Hepatic Inflammation and Tumor Necrosis Factor α-Induced Hepatocyte Damage in Hyperlipidemia-Prone ApoE-Null Mice
Marcos Martinez-Clemente et al.
HEPATOLOGY (2010)
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
Marie-Luise Berres et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity
Raquel Horrillo et al.
JOURNAL OF IMMUNOLOGY (2010)
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury
Kun Wang et al.
LABORATORY INVESTIGATION (2010)
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Shomit Sengupta et al.
NATURE (2010)
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
Vivian Barry-Hamilton et al.
NATURE MEDICINE (2010)
The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
Silvia Sookoian et al.
PHARMACOGENETICS AND GENOMICS (2010)
Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Sriram Krishnamoorthy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway
Mary D. L. Chau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice Role of Lipoxidation via Receptor-Mediated Mechanisms
Carla Iacobini et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu et al.
DIABETES (2009)
Curcumin Inhibits srebp-2 Expression in Activated Hepatic Stellate Cells in Vitro by Reducing the Activity of Specificity Protein-1
Qiaohua Kang et al.
ENDOCRINOLOGY (2009)
PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice
Hyun-Joung Lim et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
A Novel Pregnane X Receptor and S14-Mediated Lipogenic Pathway in Human Hepatocyte
Amelie Moreau et al.
HEPATOLOGY (2009)
Hepatic Recruitment of the Inflammatory Gr1+ Monocyte Subset Upon Liver Injury Promotes Hepatic Fibrosis
Karlin Raja Karlmark et al.
HEPATOLOGY (2009)
Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms
Carla Iacobini et al.
JOURNAL OF PATHOLOGY (2009)
Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet
Bo Kong et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice
Menno Hoekstra et al.
MOLECULAR PHARMACEUTICS (2009)
Increased expression and activity of the transcription factor FOX01 in nonalcoholic steatohepatitis
Luca Valenti et al.
DIABETES (2008)
Macrophage chemoattractant protein-1 deficiency fails to restrain macrophage infiltration into adipose tissue
Elizabeth A. Kirk et al.
DIABETES (2008)
Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-α control of the acute-phase response
Roxane M. Mansouri et al.
ENDOCRINOLOGY (2008)
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARγ in promoting steatosis
Jie Zhou et al.
GASTROENTEROLOGY (2008)
Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response
Yan-Dong Wang et al.
HEPATOLOGY (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
Hong Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
A lipidomic analysis of nonalcoholic fatty liver disease
Puneet Puri et al.
HEPATOLOGY (2007)
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
Cheol Soo Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Justin I. Odegaard et al.
NATURE (2007)
βKlotho is required for metabolic activity of fibroblast growth factor 21
Yasushi Ogawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation
Ken S. Lau et al.
CELL (2007)
PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1
Shen Qu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
PPARγ agonists prevent TGFβ1 Smad3-signaling in human hepatic stellate cells
Caiyan Zhao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
Anna Wieckowska et al.
HEPATOLOGY (2006)
Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro
Emma L. Haughton et al.
GASTROENTEROLOGY (2006)
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
John Willy Haukeland et al.
JOURNAL OF HEPATOLOGY (2006)
Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α
Ji Miao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet
T Nagasawa et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Farnesoid X receptor is essential for normal glucose homeostasis
K Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Galectin-3 regulates myofibroblast activation and hepatic fibrosis
NC Henderson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
S Fiorucci et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
CJ Marek et al.
BIOCHEMICAL JOURNAL (2005)
Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice
E Ip et al.
HEPATOLOGY (2004)
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
YQ Zhang et al.
GENES & DEVELOPMENT (2004)
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity
G Elad-Sfadia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats
T Toyama et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
M Watanabe et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
T Claudel et al.
GASTROENTEROLOGY (2003)
Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
YX Wang et al.
CELL (2003)
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
R Kleemann et al.
BLOOD (2003)
6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein
JW Park et al.
NUCLEIC ACIDS RESEARCH (2001)