4.8 Review

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Related references

Note: Only part of the references are listed.
Article Physiology

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

Sarah K. Orr et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Autophagy in the light of sphingolipid metabolism

Eva Bang Harvald et al.

APOPTOSIS (2015)

Review Biochemistry & Molecular Biology

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

Olof Radmark et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)

Article Biochemistry & Molecular Biology

The pharmacology of resveratrol in animals and humans

Eun-Jung Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Pharmacology & Pharmacy

Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice

P. G. Trentin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Medical Laboratory Technology

Gut-liver axis, nutrition, and non-alcoholic fatty liver disease

Irina A. Kirpich et al.

CLINICAL BIOCHEMISTRY (2015)

Review Biochemistry & Molecular Biology

CXCR3 ligands in disease and therapy

Katrien Van Raemdonck et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Review Pharmacology & Pharmacy

Targeting xenobiotic receptors PXR and CAR in human diseases

Monimoy Banerjee et al.

DRUG DISCOVERY TODAY (2015)

Article Endocrinology & Metabolism

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

Nicholas Douris et al.

ENDOCRINOLOGY (2015)

Review Pharmacology & Pharmacy

Saroglitazar for the treatment of dyslipidemia in diabetic patients

Shashank R. Joshi

EXPERT OPINION ON PHARMACOTHERAPY (2015)

Article Gastroenterology & Hepatology

Poster Session 4: Steatohepatitis: Clinical and Therapeutic

HEPATOLOGY (2015)

Article Biochemistry & Molecular Biology

Activation of mTORC1 disrupted LDL receptor pathway: A potential new mechanism for the progression of non-alcoholic fatty liver disease

Jing Liu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

Review Pharmacology & Pharmacy

Effects of formulation design on niacin therapeutics: mechanism of action, metabolism, and drug delivery

Dustin L. Cooper et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Gastroenterology & Hepatology

Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds

Chengfu Xu et al.

JOURNAL OF HEPATOLOGY (2015)

Review Biochemistry & Molecular Biology

Endogenous and exogenous mediators of quercetin bioavailability

Yi Guo et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Medicine, Research & Experimental

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

Xinlu Yuan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

Review Pharmacology & Pharmacy

The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes

Elango Bhakkiyalakshmi et al.

PHARMACOLOGICAL RESEARCH (2015)

Review Pharmacology & Pharmacy

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Chengxue Qin et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Biotechnology & Applied Microbiology

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

Silvia S. Chambel et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Immunology

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

Vladislav Volarevic et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

Galectin-3: an emerging all-out player in metabolic disorders and their complications

Giuseppe Pugliese et al.

GLYCOBIOLOGY (2015)

Article Gastroenterology & Hepatology

Galectin-3 regulates hepatic progenitor cell expansion during liver injury

Wei-Chen Hsieh et al.

Article Gastroenterology & Hepatology

Treatment Response in the PIVENS Trial Is Associated With Decreased Hedgehog Pathway Activity

Cynthia D. Guy et al.

HEPATOLOGY (2015)

Article Multidisciplinary Sciences

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

Takhar Kasumov et al.

PLOS ONE (2015)

Review Gastroenterology & Hepatology

Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis

Petra Hirsova et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2015)

Article Pharmacology & Pharmacy

Pregnane X Receptor Modulates the Inflammatory Response in Primary Cultures of Hepatocytes

Mengxi Sun et al.

DRUG METABOLISM AND DISPOSITION (2015)

Review Pharmacology & Pharmacy

An Overview of Hedgehog Signaling in Fibrosis

Liping Hu et al.

MOLECULAR PHARMACOLOGY (2015)

Article Cell Biology

Roles of Oxidized Diacylglycerol for Carbon Tetrachloride-induced Liver Injury and Fibrosis in Mouse

Susumu Takekoshi et al.

ACTA HISTOCHEMICA ET CYTOCHEMICA (2014)

Article Gastroenterology & Hepatology

Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease

Shobha H. Ganji et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Article Gastroenterology & Hepatology

Activation of N-methyl-D-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway

Ahmad Farooq et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin

Elina Isakov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Biochemistry & Molecular Biology

Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease

Georgios Grammatikos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

Article Biochemistry & Molecular Biology

AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response

Hongliang Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Pharmacology & Pharmacy

Discovery of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors with a 1H-Pyrrolo[2,3-b]pyridine Core

Mun Ock Kim et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2014)

Article Biochemistry & Molecular Biology

Human lysyl oxidase-like 2

Hee-Jung Moon et al.

BIOORGANIC CHEMISTRY (2014)

Article Immunology

Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines

Hugo You-Hsien Lin et al.

BMC IMMUNOLOGY (2014)

Article Cell Biology

Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells

Zhuo-Jian Li et al.

CELLULAR SIGNALLING (2014)

Article Gastroenterology & Hepatology

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Veronique S. Chachay et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

Review Chemistry, Medicinal

Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands

Andrea Carotti et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)

Article Endocrinology & Metabolism

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

Hongfeng Jiang et al.

DIABETOLOGIA (2014)

Article Pharmacology & Pharmacy

Discontinued in 2013: diabetic drugs

Maka S. Hedrington et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)

Article Gastroenterology & Hepatology

Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice

Irene Locatelli et al.

HEPATOLOGY (2014)

Review Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes

Andreas L. Birkenfeld et al.

HEPATOLOGY (2014)

Article Endocrinology & Metabolism

The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

E. Konings et al.

INTERNATIONAL JOURNAL OF OBESITY (2014)

Article Medicine, Research & Experimental

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

Sayaka Inokuchi-Shimizu et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Gastroenterology & Hepatology

Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation

David Castano et al.

JOURNAL OF HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Jing Dong et al.

JOURNAL OF LIPID RESEARCH (2014)

Article Genetics & Heredity

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

Alexander Wree et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

Article Biochemistry & Molecular Biology

Chronic supplementation of proanthocyanidins reduces postprandial lipemia and liver miR-33a and miR-122 levels in a dose-dependent manner in healthy rats

Laura Baselga-Escudero et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells

Laura Baselga-Escudero et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Nutrition & Dietetics

Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

Joao Marcus Oliveira Andrade et al.

NUTRITION (2014)

Article Chemistry, Multidisciplinary

Nanomedicines of Hedgehog Inhibitor and PPAR-γ Agonist for Treating Liver Fibrosis

Virender Kumar et al.

PHARMACEUTICAL RESEARCH (2014)

Review Biochemistry & Molecular Biology

Ceramide: A simple sphingolipid with unique biophysical properties

Bruno M. Castro et al.

PROGRESS IN LIPID RESEARCH (2014)

Article Gastroenterology & Hepatology

GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells

Xiao-Min Xin et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Hepatic inflammation and progressive liver fibrosis in chronic liver disease

Albert J. Czaja

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Physiology

Inhibition of acid sphingonnyelinase by tricyclic antidepressants and analogons

Nadine Beckmann et al.

FRONTIERS IN PHYSIOLOGY (2014)

Article Pharmacology & Pharmacy

Semisynthetic Bile Acid FXR and TGR5 Agonists: Physicochemical Properties, Pharmacokinetics, and Metabolism in the Rat

Aldo Roda et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Article Gastroenterology & Hepatology

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

Maryna Perepelyuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Attenuation of plasma annexin A1 in human obesity

Anna Kosicka et al.

FASEB JOURNAL (2013)

Article Food Science & Technology

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

Hua-Zhong Ying et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)

Article Gastroenterology & Hepatology

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

Maximilian Hatting et al.

HEPATOLOGY (2013)

Article Biochemistry & Molecular Biology

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies IMPLICATIONS FOR DEGRADATION OF NRF2 IN THE NUCLEUS

Melanie Theodore Malloy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Medicine, Research & Experimental

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

Giovanna Leoni et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Nrf2 deletion causes benign simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

Chunhua Wang et al.

LIPIDS IN HEALTH AND DISEASE (2013)

Article Chemistry, Organic

Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors

Kyeong Lee et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2013)

Article Multidisciplinary Sciences

Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice

Elise F. Hoek-van den Hil et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

Laura J. Dixon et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

Andrew C. Adams et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

Peter G. Traber et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Increased Adiposity in Annexin A1-Deficient Mice

Rand T. Akasheh et al.

PLOS ONE (2013)

Article Chemistry, Multidisciplinary

Identification of Three Novel Natural Product Compounds that Activate PXR and CAR and Inhibit Inflammation

Suticha Kittayaruksakul et al.

PHARMACEUTICAL RESEARCH (2013)

Article Multidisciplinary Sciences

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles

Nazila Kamaly et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

Giovanni Musso et al.

PROGRESS IN LIPID RESEARCH (2013)

Article Gastroenterology & Hepatology

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Kouichi Miura et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Hematology

Myeloid Deletion of Nuclear Factor Erythroid 2-Related Factor 2 Increases Atherosclerosis and Liver Injury

Alan R. Collins et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Nutrition & Dietetics

Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice

Su-Jung Cho et al.

BRITISH JOURNAL OF NUTRITION (2012)

Article Cell Biology

Mir-33 regulates cell proliferation and cell cycle progression

Daniel Cirera-Salinas et al.

CELL CYCLE (2012)

Article Endocrinology & Metabolism

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

Da Young Oh et al.

DIABETES (2012)

Article Biochemistry & Molecular Biology

Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

Chang Joo Oh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

Minsheng Yuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

Annie-Carole Tosello-Trampont et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Immunology

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

Joan Claria et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Immunology

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

Sorina Georgiana Boaru et al.

JOURNAL OF INFLAMMATION-LONDON (2012)

Article Multidisciplinary Sciences

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

Andrew C. Adams et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Tatiana Kisseleva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor

Guodong Li et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

Arunima Biswas et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Role of S6K1 in regulation of SREBP1c expression in the liver

Shuying Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Timothy R. Peterson et al.

Review Cell Biology

Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus

Guido T. Bommer et al.

CELL METABOLISM (2011)

Article Medicine, Research & Experimental

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

William L. Holland et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Gastroenterology & Hepatology

Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver

Carla Iacobini et al.

JOURNAL OF HEPATOLOGY (2011)

Article Biochemistry & Molecular Biology

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

Charles A. Harris et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

William L. Holland et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Bolormaa Vandanmagsar et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

The Human Serum Metabolome

Nikolaos Psychogios et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

Alberto Davalos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Francois R. Jornayvaz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Cellular senescence controls fibrosis in wound healing

Joon-Il Jun et al.

AGING-US (2010)

Review Medicine, Research & Experimental

Emerging Molecular Targets for the Treatment of Nonalcoholic Fatty Liver Disease

Giovanni Musso et al.

ANNUAL REVIEW OF MEDICINE (2010)

Article Endocrinology & Metabolism

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Ffolliott M. Fisher et al.

DIABETES (2010)

Article Pharmacology & Pharmacy

Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

Rhiannon N. Hardwick et al.

DRUG METABOLISM AND DISPOSITION (2010)

Article Gastroenterology & Hepatology

Accumulation of Natural Killer T Cells in Progressive Nonalcoholic Fatty Liver Disease

Wing-Kin Syn et al.

HEPATOLOGY (2010)

Article Medicine, Research & Experimental

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

Marie-Luise Berres et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Medicine, Research & Experimental

The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury

Kun Wang et al.

LABORATORY INVESTIGATION (2010)

Article Multidisciplinary Sciences

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Shomit Sengupta et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment

Vivian Barry-Hamilton et al.

NATURE MEDICINE (2010)

Article Biotechnology & Applied Microbiology

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

Silvia Sookoian et al.

PHARMACOGENETICS AND GENOMICS (2010)

Article Multidisciplinary Sciences

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

Sriram Krishnamoorthy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

Mary D. L. Chau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Hematology

Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice Role of Lipoxidation via Receptor-Mediated Mechanisms

Carla Iacobini et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Pharmacology & Pharmacy

PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice

Hyun-Joung Lim et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Article Gastroenterology & Hepatology

A Novel Pregnane X Receptor and S14-Mediated Lipogenic Pathway in Human Hepatocyte

Amelie Moreau et al.

HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Hepatic Recruitment of the Inflammatory Gr1+ Monocyte Subset Upon Liver Injury Promotes Hepatic Fibrosis

Karlin Raja Karlmark et al.

HEPATOLOGY (2009)

Article Pharmacology & Pharmacy

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

Bo Kong et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Gastroenterology & Hepatology

Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response

Yan-Dong Wang et al.

HEPATOLOGY (2008)

Article Biochemistry & Molecular Biology

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Dana M. Gwinn et al.

MOLECULAR CELL (2008)

Article Gastroenterology & Hepatology

A lipidomic analysis of nonalcoholic fatty liver disease

Puneet Puri et al.

HEPATOLOGY (2007)

Article Multidisciplinary Sciences

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Justin I. Odegaard et al.

NATURE (2007)

Article Multidisciplinary Sciences

βKlotho is required for metabolic activity of fibroblast growth factor 21

Yasushi Ogawa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Endocrinology & Metabolism

PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1

Shen Qu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Biochemistry & Molecular Biology

PPARγ agonists prevent TGFβ1 Smad3-signaling in human hepatic stellate cells

Caiyan Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Gastroenterology & Hepatology

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro

Emma L. Haughton et al.

GASTROENTEROLOGY (2006)

Article Gastroenterology & Hepatology

Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2

John Willy Haukeland et al.

JOURNAL OF HEPATOLOGY (2006)

Article Medicine, Research & Experimental

Farnesoid X receptor is essential for normal glucose homeostasis

K Ma et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

Galectin-3 regulates myofibroblast activation and hepatic fibrosis

NC Henderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Oncology

Implication of galectin-3 in Wnt signaling

T Shimura et al.

CANCER RESEARCH (2005)

Article Biochemistry & Molecular Biology

Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

G Elad-Sfadia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats

T Toyama et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Medicine, Research & Experimental

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

M Watanabe et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Gastroenterology & Hepatology

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

T Claudel et al.

GASTROENTEROLOGY (2003)

Article Biochemistry & Molecular Biology

Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein

JW Park et al.

NUCLEIC ACIDS RESEARCH (2001)