Journal
PHARMACEUTICALS
Volume 16, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ph16070965
Keywords
Sorbus intermedia; terpenoids; benign prostatic hyperplasia; antiproliferative activity; antiandrogenic activity; anti-inflammatory activity; fruits
Categories
Ask authors/readers for more resources
This study investigated the anti-BPH potential of terpenoids in the fruits of Sorbus intermedia. The results showed that these compounds inhibited 5-α-reductase activity and reduced PSA secretion in normal prostate epithelial cells. They also demonstrated inhibitory effects on heat-induced protein denaturation, hyaluronidase, as well as IL-6, TNF-α, and NO release in macrophages.
Benign prostatic hyperplasia (BPH) is a common urological disease affecting aging men. Its pathogenesis is regarded as complex and multifactorial, with sex hormones and inflammation as key contributory factors. In the current study, we investigated the anti-BPH potential of terpenoids present in the fruits of Sorbus intermedia (EHRH.) PERS. Not only the effects on testosterone-stimulated normal prostate epithelial PNT2 cells, namely suppression of 5-& alpha;-reductase activity, PSA secretion, and cell proliferation, were determined but also the inhibitory activity on heat-induced protein denaturation, hyaluronidase, as well as IL-6, TNF-& alpha;, and NO release in LPS-treated macrophages. Sorbus terpenoids significantly inhibited 5-& alpha;-reductase activity and reduced PSA secretion in PNT2 cells, reversing the stimulatory effect of testosterone. PNT2 cell proliferation was also found to be attenuated. Subsequently, all compounds reduced the release of pro-inflammatory mediators in RAW 264.7 cells. In addition, ursolic acid (UA) and its aldehyde (UAL) were the most potent hyaluronidase inhibitors of all compounds, with IC50 values of 225.75 & mu;g/mL and 369.77 & mu;g/mL, respectively. For better understanding and interpretation of the overall effect of Sorbus terpenoids on different aspects of BPH pathogenesis and development, cluster analysis was applied.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available