Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 4, Pages 275-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2015.21
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Funding
- US Department of Veterans Affairs
- US National Institute on Aging [R01 AG046619]
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One of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders is achieving sufficient blood-brain barrier (BBB) penetration. Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease. This complexity confounds simple strategies for drug delivery to the CNS, but provides a wealth of opportunities and approaches for drug development. Here, I review some of the most important areas that have recently redefined the BBB and discuss how they can be applied to the development of CNS therapeutics.
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