Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/jpm13081238
Keywords
glomerular filtration rate; kidney dysfunction; adipokines; young population; dyslipidemia
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This study found that in young people with dyslipidemia, abdominal obesity and increased resistin and GIP levels are associated with the presence of renal dysfunction.
Background: There are data supporting the idea that atherogenic dyslipidemia is a risk factor for CKD and reduced GFR. The aim was to evaluate the associations between adipocytokines and early renal dysfunction in young people with dyslipidemia. Materials and methods: A population study was conducted in IIPM-Branch of IC & G SB RAS, in 2013-2017. Furthermore, 1033 people were included in the study (469 men (45.4%) and 564 women (54.6%)). The study included blood sampling, anthropometric data, and adipokines by multiplex analysis. Results: Among people with reduced kidney function and DLP, men were 3.1 times more common than without DLP, women smoked 2 times less often, arterial hypertension was 7.8 times more common, and abdominal obesity was 2.7 times more common (and women with DLP were 3 times more likely than those without DLP). An increase in the level of resistin by 1 mcg/mL was associated with an increased chance of having renal dysfunction by 0.2%. An increase in the level of GIP was associated with an increased chance of having renal dysfunction by 1.1%. Conclusions: In young people with dyslipidemia, regardless of the presence of abdominal obesity, resistin and GIP are associated with the presence of renal dysfunction.
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