Journal
ISCIENCE
Volume 26, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2023.108064
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This study reveals the reduced expression of TR(3) during the progression of NASH, indicating the development of thyroid hormone resistance. Surprisingly, increasing TR(3) expression does not improve NASH pathology, gene expression, or metabolic parameters in mice. The study suggests that liver-targeted approaches may be more relevant for NASH treatment with thyroid hormone receptor agonists.
Agonists for thyroid hormone receptor (3 (TR(3) show promise in preclinical studies and clinical trials to improve non-alcoholic fatty liver disease. A recent study on human livers, however, revealed reduced TR(3 expression in non-alcoholic steatohepatitis (NASH), indicating a developing thyroid hormone resistance, which could constitute a major obstacle for those agonists. Using a rapid NASH paradigm combining choline-deficient high-fat diet and thermoneutrality, we confirm that TR(3 declines during disease progression in mice similar to humans. Contrary to expectations, mice lacking TR(3 showed less liver fibrosis, and NASH marker genes were not elevated. Conversely, increasing TR(3 expression in wild-type NASH mice using liver-targeted gene therapy did not improve histology, gene expression, or metabolic parameters, indicating that TR(3 receptor levels are of minor relevance for NASH development and progression in our model, and suggest that liver-rather than isoform-specificity might be more relevant for NASH treatment with thyroid hormone receptor agonists.
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