Journal
ISCIENCE
Volume 26, Issue 9, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2023.107453
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Music-based melodic intonation therapy (MIT) shows promise as a treatment for non-fluent aphasia after stroke, with positive effects on reorganization and activation of the arcuate fasciculus in the brain.
Music-based melodic intonation therapy (MIT) has shown promise as a treatment for non-fluent aphasia after stroke. This trial compared the efficacy of music-based MIT and speech therapy (ST) in aphasia, focusing on arcuate fasciculus connectivity in brain structural and language ability scores. A total of 62 patients were enrolled, of whom 40 completed the trial. The experimental group received MIT for 30 min/d, five days per week for four weeks, while the control group received ST with the same dose. The BDAE and fMRI-DTI were performed at T0 and T1. The music-based MIT group demonstrated better language levels. DTI showed that FA, FN, and path length of the MIT group in the right hemisphere were significantly increased. Music-based MIT had positive effects on reorganization and activation of arcuate fasciculus in aphasia after stroke.
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