Journal
JOURNAL OF FUNGI
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/jof9101009
Keywords
Fusarium graminearum; protein disulfide isomerase FgEps1; fungal growth; virulence factor
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This study investigated the biological functions of FgEps1, a disulfide bond isomerase in the fungal pathogen Fusarium graminearum. The results showed that FgEps1 plays important roles in nutritional growth, reproduction, stress tolerance, pathogenicity, toxin biosynthesis, and host infection. Further investigation revealed that FgEps1 suppresses the immune response of plants and promotes infection.
Protein disulfide isomerase (PDI) is a member of the thioredoxin (Trx) superfamily with important functions in cellular stability, ion uptake, and cellular differentiation. While PDI has been extensively studied in humans and animals, its role in fungi remains relatively unknown. In this study, the biological functions of FgEps1, a disulfide bond isomerase in the fungal pathogen Fusarium graminearum, were investigated. It was found that FgEps1 mutation affected nutritional growth, asexual and sexual reproduction, and stress tolerance. Additionally, its deletion resulted in reduced pathogenicity and impaired DON toxin biosynthesis. The involvement of FgEps1 in host infection was also confirmed, as its expression was detected during the infection period. Further investigation using a yeast signal peptide secretion system and transient expression in Nicotiana benthamiana showed that FgEps1 suppressed the immune response of plants and promoted infection. These findings suggest that virulence factor FgEps1 plays a crucial role in growth, development, virulence, secondary metabolism, and host infection in F. graminearum.
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