4.6 Article

Paracoccidioides brasiliensis Induces α3 Integrin Lysosomal Degradation in Lung Epithelial Cells

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Targeting integrin pathways: mechanisms and advances in therapy

Xiaocong Pang et al.

Summary: Integrins are cell-adhesion receptors that play important roles in cell signaling and communication. Targeting integrins for therapeutic purposes has been challenging due to their complexity and opposing characteristics. Currently, there are only seven approved drugs targeting integrins on the market, but there are ongoing efforts to develop new therapies and diagnostic tools. Understanding the regulatory mechanisms of integrins and addressing unmet clinical needs are crucial for successful development of integrin-targeted therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Article Oncology

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Shiv Ram Krishn et al.

Summary: The alpha V beta 6 integrin is upregulated during prostate cancer progression and specifically expressed in androgen receptor-negative tumors. By delivering ITGB6-targeting siRNAs into PrCa cells using sEVs, the expression of beta 6 subunit can be downregulated, leading to reduced cell adhesion and migration in PrCa cells.

CANCER BIOLOGY & THERAPY (2022)

Review Biochemistry & Molecular Biology

Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases

Hiroko Ikeshima-Kataoka et al.

Summary: The integrin family plays important roles in various biological functions and disease pathogenesis. They are multifunctional receptors composed of alpha and beta subunits, binding to various ligands including extracellular matrix proteins. Integrins are found in both vertebrates and invertebrates, and are widely used in genetic and disease research. This paper discusses the phylogenetic analysis of the integrin family among different species, summarizes integrin signaling in teleost fish, and highlights the potential of drug development targeting integrins for the treatment of neurodegenerative diseases and brain injury in mammals.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2

Jiamnin Liu et al.

Summary: This study reveals that SARS-CoV-2 can enter cells not only by binding to ACE2 through its spike protein, but also by binding to integrin alpha 5 beta 1. The activation of integrin plays a critical role in facilitating the internalization of SARS-CoV-2 into non-ACE2 cells. This alternative pathway for cell entry may contribute to the further infection and progression of COVID-19.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Microbiology

Respiratory Epithelial Cells: More Than Just a Physical Barrier to Fungal Infections

Bianca C. S. C. Barros et al.

Summary: The response of respiratory epithelial cells to fungal pathogens involves complex cellular interactions, including cell signaling, adhesion, invasion, and cytokine secretion.

JOURNAL OF FUNGI (2022)

Review Biology

Pathways of integrins in the endo-lysosomal system

Marton Molnar et al.

Summary: This review summarizes recent scientific advances in the understanding of integrin trafficking in the endo-lysosomal system. It provides an overview of the internalization and recycling pathways of integrins, as well as the potential mechanisms of lysosomal degradation. The regulation of integrin internalization and recycling is a complex process that plays a critical role in cellular adhesion and migration. Dysregulation of this process can contribute to tumorigenesis and metastasis. Therefore, studying integrins in the endo-lysosomal system is of great importance, as it may lead to the identification of potential therapeutic targets and further insights into integrin signaling and adhesion-related processes.

BIOLOGIA FUTURA (2022)

Review Biology

The role of K63-linked polyubiquitin in several types of autophagy

Anna Dosa et al.

Summary: Lysosomal-dependent self-degradative mechanisms play a crucial role in maintaining cellular homeostasis. This review focuses on the role of K63-linked polyubiquitin in various autophagic processes.

BIOLOGIA FUTURA (2022)

Article Chemistry, Multidisciplinary

Bifunctional Compounds as Molecular Degraders for Integrin- Facilitated Targeted Protein Degradation

Jiwei Zheng et al.

Summary: The novel IFLD strategy utilizes integrin and lysosome to establish a targeted protein degradation approach that effectively degrades extracellular and cell membrane proteins. Its feasibility has been demonstrated in vitro and in vivo, expanding the toolbox for protein regulation.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Review Biochemistry & Molecular Biology

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Yolanda Olmos

Summary: This article reviews the molecular mechanisms of membrane constriction and scission by ESCRT-III and describes its essential role in sealing and repairing damaged cellular membranes.

MEMBRANES (2022)

Review Microbiology

Paracoccidioidomycosis: Current Status and Future Trends

Rosane Christine Hahn et al.

Summary: Paracoccidioidomycosis (PCM) is a systemic and neglected tropical mycosis primarily affecting individuals in Latin America, especially Brazil. Recent advances in molecular taxonomy have identified several cryptic species of the causative fungus, Paracoccidioides, which can affect various organs. The diagnosis of PCM traditionally relies on microscopy, culture-based, biochemical, and immunological assays, but molecular assays are needed for accurate identification. Treatment options should consider factors such as organ involvement, disease severity, previous treatment history, and patient compliance. Despite appropriate treatment, relapses can occur, and PCM can be misdiagnosed as other diseases.

CLINICAL MICROBIOLOGY REVIEWS (2022)

Article Biochemistry & Molecular Biology

Pristimerin exerts antitumor activity against MDA-MB-231 triple-negative breast cancer cells by reversing of epithelial-mesenchymal transition via downregulation of integrin β3

Shiyue Liu et al.

Summary: The study demonstrated that pristimerin inhibits tumor growth and reverts EMT by suppressing integrin beta 3, providing important insights into its potential anti-cancer effects.

BIOMEDICAL JOURNAL (2021)

Article Multidisciplinary Sciences

Integrin activation is an essential component of SARS-CoV-2 infection

Peter Simons et al.

Summary: SARS-CoV-2 infection relies on the binding of its spike protein to ACE2, with integrins potentially acting as co-receptors. Integrins play a crucial role in mediating cell entry and infection, with talin-mediated signaling being essential for the productive infection process.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Review Cell Biology

Life in the lumen: The multivesicular endosome

Jean Gruenberg

TRAFFIC (2020)

Article Multidisciplinary Sciences

Structure and assembly of ESCRT-III helical Vps24 filaments

Stefan T. Huber et al.

SCIENCE ADVANCES (2020)

Review Immunology

Regulatory cytokine function in the respiratory tract

William J. Branchett et al.

MUCOSAL IMMUNOLOGY (2019)

Review Cell Biology

Integrin diversity brings specificity in mechanotransduction

Shailaja Seetharaman et al.

BIOLOGY OF THE CELL (2018)

Letter Immunology

Paracoccidioidomycosis after Highway Construction, Rio de Janeiro, Brazil

Antonio C. Francesconi do Valle et al.

EMERGING INFECTIOUS DISEASES (2017)

Article Cell Biology

Hepatitis B Virus X Protein Reduces Podocyte Adhesion via Downregulation of α3β1 Integrin

Ping He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Review Cell Biology

Signal processing by the endosomal system

Roberto Villasenor et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Endocytic Trafficking of Integrins in Cell Migration

Nikki R. Paul et al.

CURRENT BIOLOGY (2015)

Article Respiratory System

Novel concepts in airway inflammation and remodelling in asthma

Sejal Saglani et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Review Neurosciences

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

Yong-Bo Hu et al.

TRANSLATIONAL NEURODEGENERATION (2015)

Review Microbiology

RAB11-mediated trafficking in host-pathogen interactions

Annabel Guichard et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Integrins modulate the infection efficiency of West Nile virus into cells

Katja Schmidt et al.

JOURNAL OF GENERAL VIROLOGY (2013)

Article Cell Biology

Integrin Structure, Activation, and Interactions

Iain D. Campbell et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Ubiquitin: Same Molecule, Different Degradation Pathways

Michael J. Clague et al.

Review Immunology

The Role of Epithelial Integrin Receptors in Recognition of Pulmonary Pathogens

Marina Ulanova et al.

JOURNAL OF INNATE IMMUNITY (2009)

Review Biochemistry & Molecular Biology

Physiological and pathological roles of α3β1 integrin

T Tsuji

JOURNAL OF MEMBRANE BIOLOGY (2004)