Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review

Focal active colitis (FAC) is described as a histolopathological term indicating the isolated finding of focal neutrophil infiltration in the colonic crypts. Currently, there exist numerous debates regarding the clinical significance of diagnosing FAC, which may or may not have clinical relevance as it is frequently detected in colorectal biopsies without any other microscopic abnormalities. The objective of this narrative review is to provide an overview of the available evidence concerning the clinical implications of FAC, both in the adult population (among five studies available in the scientific literature) and in the pediatric context (based on two available studies).

Automated summary

Focal active colitis (FAC) refers to the isolated finding of neutrophil infiltration in the colonic crypts, causing debates about its clinical significance. This narrative review aims to provide an overview of the available evidence regarding the clinical implications of FAC in both adults and pediatric populations.