4.7 Review

Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study

Charlotte Rose Lemech et al.

Summary: Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential for DNA replication, repair and scaffold functions in the cytosol. Inhibition of PCNA in cancer cells with ATX-101 has been shown to have anti-cancer activity and enhance the effectiveness of anti-cancer therapies.

ONCOGENE (2023)

Article Biotechnology & Applied Microbiology

Tumor-penetrating nanoplatform with ultrasound unlocking for cascade synergistic therapy and visual feedback under hypoxia

Zhuoyan Xie et al.

Summary: A visualizable nanoplatform named HtLyP-1(Gd)-GOD@PFP was constructed, which could achieve ultrasound imaging, starvation therapy, and sonodynamic therapy under the guidance of MR/PA imaging. The nanoplatform could generate a large amount of ROS and provide sufficient oxygen, leading to significant tumor inhibition.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

Review Chemistry, Medicinal

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

So Hee Nam et al.

Summary: Cell-penetrating peptides (CPPs) have been used to enhance the delivery of bioactive and therapeutic agents by increasing interaction with the cell membrane. However, their non-specific targeting limits their medical applications.

ARCHIVES OF PHARMACAL RESEARCH (2023)

Review Pharmacology & Pharmacy

An update on cell-penetrating peptides with intracellular organelle targeting

Carmine Pasquale Cerrato et al.

Summary: This review provides an overview of CPP technologies for intracellular organelle targeting, discussing their pharmacological and therapeutical applications. Targeted drug delivery to specific organelles offers improved efficacy, control of mode of action, and potential to overcome drug resistance mechanisms.

EXPERT OPINION ON DRUG DELIVERY (2022)

Article Chemistry, Multidisciplinary

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells

Ole Tietz et al.

Summary: This study identifies a method to deliver antibodies and antibody fragments into the cytosol and nucleus of cells using trimeric cell-penetrating peptides (CPPs). By utilizing these peptides, it overcomes a major obstacle in intracellular targeting, which is the entrapment of biomacromolecules in the endosome.

NATURE CHEMISTRY (2022)

Article Pharmacology & Pharmacy

Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery

Muhammad Imran Sajid et al.

Summary: Recent approvals of siRNA-based products have led to exploration of siRNA as a potential treatment option for cancer and other diseases. This study introduces a series of oleyl-conjugated histidine-arginine peptides as a promising nonviral siRNA delivery tool.

PHARMACEUTICS (2022)

Article Chemistry, Medicinal

Ultrasound-dependent RNAi using TatU1A-rose bengal conjugate

Nanako Sumi et al.

Summary: TatU1A-RB, an ultrasound-sensitive RNA carrier molecule, delivers RNA through endocytosis and achieves endosomal escape and cytosolic dispersion by ultrasound. This ultrasound-dependent RNA delivery method serves as the foundation for novel nucleic acid therapeutics.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

Article Biotechnology & Applied Microbiology

Autophagy responsive intra-intercellular delivery nanoparticles for effective deep solid tumor penetration

Fengling Wang et al.

Summary: Deep tumor cells are crucial in drug tolerance, metastasis, and recurrence, but their location makes them difficult to target with current treatments. Autophagy-responsive multifunctional nanoparticles designed to enhance drug accumulation in these deep tumor cells showed excellent antitumor efficacy in vivo, providing a novel potential strategy for solid tumor treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Nanoscience & Nanotechnology

Tumor-Associated Neutrophil Extracellular Traps Regulating Nanocarrier-Enhanced Inhibition of Malignant Tumor Growth and Distant Metastasis

Haoyuan Yin et al.

Summary: The smart nanocarrier mP-NPs-DNase/PTX can degrade NETs structure by releasing DNase I at tumor tissue, mediate tumor cell uptake through exposed cell penetrating peptide, and exert cytotoxic effect by releasing PTX. It shows potential as a NET-regulated nanocarrier for inhibiting malignant tumor growth and metastasis.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Engineering, Biomedical

Coadministration of iRGD peptide with ROS-sensitive nanoparticles co-delivering siFGL1 and siPD-L1 enhanced tumor immunotherapy

Wen-Jun Wan et al.

Summary: The study focused on using a novel intelligent nano-delivery system for co-delivery of siFGL1 and siPD-L1, resulting in down-regulation of FGL1 and PD-L1 protein levels in tumor cells. The project proposed a new strategy for tumor immunotherapy based on smart nano-delivery systems, showcasing the potential for nanoparticle-mediated cancer immunotherapy. This research may offer more insights into the effectiveness of nanoparticle delivery in cancer treatment.

ACTA BIOMATERIALIA (2021)

Article Engineering, Biomedical

Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment

Yanhong Liu et al.

Summary: A biomineralization-inspired dasatinib nanodrug was developed to overcome the key obstacles in the treatment of solid tumors, showing significant inhibition of tumor growth and metastasis by sequentially permeating through the major leakage barriers.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Multifunctionalized Gold Sub-Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma

Cheng-Yuan Dong et al.

Summary: The study demonstrates the potential advantages of the integrated pharmaceutics D-iGSNPs in treating glioblastoma, enhancing sensitivity to radiotherapy and achieving almost the same therapeutic effect as high-dose radiotherapy.

SMALL (2021)

Article Nanoscience & Nanotechnology

A Novel Peptide-Equipped Exosomes Platform for Delivery of Antisense Oligonucleotides

Huiying Xu et al.

Summary: Exosomes are natural delivery vehicles with features like low immunogenicity, excellent biocompatibility, and migration capability. This study developed a novel peptide-equipped exosomes platform that can improve cellular uptake efficiency and deliver nucleic acids effectively, showing potential for personalized cancer medicine.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to DABCYL

Shaswati Mandal et al.

Summary: The fusion of modified cell-penetrating peptides with synthetic protein analogues can enhance the uptake efficiency of fluorescently labelled proteins in live cells, offering potential for functional studies.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Chemistry, Multidisciplinary

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

Pooyan Makvandi et al.

Summary: This article discusses the exposure of humans to nanobiovectors and nanomaterials, as well as the interactions between cell membranes and these nanostructures, providing insights for scientists to design better biomedical nanomaterials. It also highlights the importance of understanding viral infections and their treatment.

NANO TODAY (2021)

Article Chemistry, Physical

pH-dependent reversibly activatable cell-penetrating peptides improve the antitumor effect of artemisinin-loaded liposomes

Yinglan Yu et al.

Summary: Artemisinin, well known as an antimalarial drug, can also be used for inflammation and cancer treatment. Studies have shown that utilizing a reversibly activatable cell-penetrating peptide can enhance the concentration of artemisinin in tumors, leading to improved antitumor effects.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Chemistry, Multidisciplinary

pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer

So Hee Nam et al.

Summary: The designed pH-activatable cell-penetrating peptide dimer LH2 with histidine residues is able to penetrate cells specifically in weak acidic conditions, delivering paclitaxel effectively into triple-negative breast cancer cells. Both non-covalent complexes (PTX-LH2(M)) and covalent conjugates (PTX-LH2(C)) of LH2 show strong antitumor effects in a triple-negative breast cancer grafted mouse model at extremely low dosages, indicating potential for targeted drug delivery and therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Nanoscience & Nanotechnology

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

Joshua J. Rennick et al.

Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.

NATURE NANOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Challenge to overcome current limitations of cell-penetrating peptides

Gyu Chan Kim et al.

Summary: Cell-penetrating peptides (CPPs) serve as efficient vehicles for delivering pharmaceutical drugs across biological membranes. Research has focused on understanding the mechanism of penetration and exploring various biomedical applications. Strategies are being developed to overcome current limitations in stability, selectivity, and efficacy of CPPs.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2021)

Article Biotechnology & Applied Microbiology

Tumor microenvironment-activated cancer cell membrane-liposome hybrid nanoparticle-mediated synergistic metabolic therapy and chemotherapy for non-small cell lung cancer

Wei Zhang et al.

Summary: The research integrates cancer cell membranes with switchable peptide-based charge-reversal liposome membranes to create a hybrid nanoplatform for smart drug delivery. This platform demonstrates excellent drug release and targeted therapy effects triggered by pH and redox, with potential therapeutic applications for non-small cell lung cancer.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Cppsite 2.0: An Available Database of Experimentally Validated Cell-Penetrating Peptides Predicting their Secondary and Tertiary Structures

Kimia Kardani et al.

Summary: One of the major challenges in drug and vaccine development is finding an effective delivery system, with cell-penetrating peptides playing a crucial role in this process. Using computational methods and online servers to predict and design CPPs before conducting experiments can save time and costs in laboratories. Various online servers and curated databases have been developed to provide prediction and validated information about CPPs.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Recent Advances and Trends in Chemical CPP-Drug Conjugation Techniques

Felix Gayraud et al.

Summary: This review focuses on recent developments in conjugation techniques for synthesizing cell-penetrating peptide (CPP)-drug conjugates targeting cancer cells, including small organic molecules and metal complexes as cytostatic payloads. The use of bifunctional linkers is gaining attention due to its advantages in linker chemistry, with three main categories of linkers highlighted. Pros and cons of each technique are thoroughly discussed to aid in choosing the optimal conjugation technique for synthesizing a specific CPP-drug conjugate.

MOLECULES (2021)

Review Chemistry, Multidisciplinary

Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy

Cheng Yu et al.

Summary: Gene therapy presents a promising approach for treating genetic disorders, but challenges remain with viral vectors. The emergence of nanomedicine has revolutionized the field of gene therapy, with recent advancements in stimulus-responsive nonviral nanocarriers showing high efficiency in delivering therapeutic nucleic acids.

ADVANCED SCIENCE (2021)

Article Nanoscience & Nanotechnology

Peptide-Targeted High-Density Lipoprotein Nanoparticles for Combinatorial Treatment against Metastatic Breast Cancer

Chuli Jiang et al.

Summary: In this study, a peptide-functionalized dual-targeting delivery system encapsulating paclitaxel and GANT61 in tLyP-1 peptide-modified reconstituted high-density lipoprotein nanoparticles was designed for metastatic TNBC treatment. The nanoparticles targeted tumor cells and facilitated drug delivery, resulting in enhanced suppression of metastasis-related tumor cell activities. The dual-targeting tLyP-1-rHDL nanoparticles showed superior efficiency in disrupting proliferation and inducing apoptosis in tumor cells compared to drug solutions, providing a promising strategy for metastatic TNBC treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Nanoscience & Nanotechnology

Enhanced Penetrability of a Tetrahedral Framework Nucleic Acid by Modification with iRGD for DOX-Targeted Delivery to Triple-Negative Breast Cancer

Mengting Liu et al.

Summary: A DNA-based drug delivery system with iRGD decoration was developed to overcome the poor penetrability and nonselective distribution of chemotherapeutic drugs for TNBC, showing superior drug penetration and targeting properties.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Biochemistry & Molecular Biology

Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor

Neha S. Gandhi et al.

Summary: SOX2 is an oncogenic transcription factor overexpressed in certain breast cancers, and studies have shown that its activity can be inhibited by designing specific interference peptides, leading to reduced proliferation of breast cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Nanoscience & Nanotechnology

Effective Antitumor of Orally Intestinal Targeting Penetrating Peptide-Loaded Tyroserleutide/PLGA Nanoparticles in Hepatocellular Carcinoma

Chenjun Ma et al.

Summary: The study established an effective oral drug delivery system for anti-hepatoma drugs by preparing YSL-PLGA/R6LRVG NPs. These nanoparticles exhibited good drug loading efficiency, cellular uptake, in vitro bioactivity, and in vivo anticancer effects. The findings suggest that the YSL-PLGA/R6LRVG NPs could serve as a useful platform for the oral delivery of anticancer drugs.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Chemistry, Multidisciplinary

Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy

Huan Liang et al.

Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Oncology

Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity

Xiaolei Zhou et al.

Summary: Activation of p53 by MDM2 inhibitors induces the expression of ERVs, partly through epigenetic factors LSD1 and DNMT1. The IFN response caused by ERV derepression upon p53-targeting therapies provides a potential way to overcome immune checkpoint blockade resistance and transform cold tumors into hot.

CANCER DISCOVERY (2021)

Article Engineering, Biomedical

Mitochondrial Metabolism Targeted Nanoplatform for Efficient Triple-Negative Breast Cancer Combination Therapy

Lu Lu et al.

Summary: The study introduces a novel nanocarrier for breast cancer treatment that targets both tumors and mitochondria, demonstrating great potential in enhancing the efficacy of cancer therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Deeply Infiltrating iRGD-Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT-Mediated Chemosensitization and Strengthened Integrin Targeting-Based Antimigration

Honglan Wang et al.

Summary: The study demonstrated the potential of iRGD-modified graphene oxide (IPHG) nanosheets for targeted delivery to treat metastatic tumors, enhancing chemotherapeutic effects and suppressing tumor metastasis through photothermal therapy. This tailored design provides a promising paradigm for combating tumor resistance and metastasis.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Multidisciplinary Sciences

Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Siyuan Yu et al.

Summary: The authors present an intracellular protein delivery system that overcomes the limitations of ineffective endosomal escape and low serum tolerance associated with cell-penetrating peptide-mediated protein delivery. This system shows efficient delivery and therapeutic efficacy in a liver failure model, highlighting the potential of using multifunctional chimaeric peptides for developing cell-penetrating peptide-based protein delivery systems.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

ConjuPepDB: a database of peptide-drug conjugates

Balazs Balogh et al.

Summary: Peptide-drug conjugates are organic molecules composed of small drug molecules, peptides, and linkers. Targeted delivery enhances drug efficacy and reduces side effects. ConjuPepDB, a database for peptide-drug conjugates, provides basic information and application details for over 1600 conjugates from various publications.

NUCLEIC ACIDS RESEARCH (2021)

Article Materials Science, Biomaterials

UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro

Shuai Zhou et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Editorial Material Biotechnology & Applied Microbiology

Emerging patent landscape for non-viral vectors used for gene therapy

Virginia Picanco-Castro et al.

NATURE BIOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier

Shiqi Huang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Multidisciplinary Sciences

Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

Hongpeng Shi et al.

SCIENCE ADVANCES (2020)

Review Biochemistry & Molecular Biology

Endogenous toxic metabolites and implications in cancer therapy

Namgyu Lee et al.

ONCOGENE (2020)

Review Biochemistry & Molecular Biology

Activatable cell-penetrating peptides: 15 years of research

Heleen de Jong et al.

RSC CHEMICAL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Theranostic Nanomedicine for Synergistic Chemodynamic Therapy and Chemotherapy of Orthotopic Glioma

Junyi Tan et al.

ADVANCED SCIENCE (2020)

Article Biotechnology & Applied Microbiology

Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery

Gaowei Hu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides

Bei-Bei Han et al.

CHEMICAL COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Detection of Extracellular Vesicle RNA Using Molecular Beacons

Getulio Pereira de Oliveira et al.

ISCIENCE (2020)

Review Biochemistry & Molecular Biology

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

Justine Habault et al.

MOLECULES (2019)

Article Pharmacology & Pharmacy

A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape

Yihua Yang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Chemistry, Multidisciplinary

Understanding Cell Penetration of Cyclic Peptides

Patrick G. Dougherty et al.

CHEMICAL REVIEWS (2019)

Review Nanoscience & Nanotechnology

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

Ghanbar Mahmoodi Chalbatani et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Chemistry, Multidisciplinary

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

Isabelle M. S. Degors et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Huan Ye et al.

BIOMACROMOLECULES (2019)

Review Pharmacology & Pharmacy

Cell penetrating peptides: the potent multi-cargo intracellular carriers

Kimia Kardani et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Article Chemistry, Multidisciplinary

Optimizing biodegradable nanoparticle size for tissue-specific delivery

Hanna K. Mandl et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Biotechnology & Applied Microbiology

Ultrasmall nanostructured drug based pH-sensitive liposome for effective treatment of drug-resistant tumor

Yanyan Li et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Click to enter: activation of oligo-arginine cell-penetrating peptides by bioorthogonal tetrazine ligations

Saskia A. Bode et al.

CHEMICAL SCIENCE (2019)

Article Chemistry, Multidisciplinary

Activatable cell-biomaterial interfacing with photo-caged peptides

Yiyang Lin et al.

CHEMICAL SCIENCE (2019)

Review Biochemistry & Molecular Biology

Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review

Sara Silva et al.

BIOMOLECULES (2019)

Article Biochemistry & Molecular Biology

Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake

Mallory R. Gordon et al.

BIOMACROMOLECULES (2018)

Article Biochemistry & Molecular Biology

Photoswitching of Cell Penetration of Amphipathic Peptides by Control of alpha-Helical Conformation

Gyu Chan Kim et al.

BIOMACROMOLECULES (2018)

Article Pathology

Epstein–Barr Virus and Cancer

Paul J. Farrell

Annual Review of Pathology-Mechanisms of Disease (2018)

Review Chemistry, Multidisciplinary

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

Martin P. Stewart et al.

CHEMICAL REVIEWS (2018)

Article Cell Biology

Viral escape from endosomes and host detection at a glance

Jacqueline Staring et al.

JOURNAL OF CELL SCIENCE (2018)

Review Virology

Baculovirus as a Tool for Gene Delivery and Gene Therapy

Chikako Ono et al.

VIRUSES-BASEL (2018)

Article Pharmacology & Pharmacy

Smart pH responsive drug delivery system based on poly(HEMA-co-DMAEMA) nanohydrogel

Amir Roointan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Clinical Neurology

Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose-Escalation Multicenter Study

Joseph Jankovic et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2018)

Review Pharmacology & Pharmacy

Cell-penetrating peptides with intracellular organelle targeting

Carmine Pasquale Cerrato et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

Article Nanoscience & Nanotechnology

Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system

Bai Xiang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Chemistry, Multidisciplinary

Bioreducible branched poly(modified nona-arginine) cell-penetrating peptide as a novel gene delivery platform

Jisang Yoo et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Chemistry, Multidisciplinary

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

Misao Akishiba et al.

NATURE CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides

Azam Bolhassani et al.

PEPTIDES (2017)

Review Chemistry, Multidisciplinary

Nanotechnology for Multimodal Synergistic Cancer Therapy

Wenpei Fan et al.

CHEMICAL REVIEWS (2017)

Review Oncology

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

Michael F. Naso et al.

BIODRUGS (2017)

Review Pharmacology & Pharmacy

Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration

Zhuxian Zhou et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Hematology

Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease

Paul A. Gurbel et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Review Microbiology

Pore-forming toxins: ancient, but never really out of fashion

Matteo Dal Peraro et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Article Biochemistry & Molecular Biology

CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides

Piyush Agrawal et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Nanoscience & Nanotechnology

ε-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo

Lisi Xie et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Pharmacology & Pharmacy

Opportunities and challenges in combination gene cancer therapy

Kent L. Nastiuk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Biochemistry & Molecular Biology

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

Ziqing Qian et al.

BIOCHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides

Andreas Prestel et al.

CHEMICAL COMMUNICATIONS (2016)

Review Chemistry, Multidisciplinary

Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

Juan Li et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Chemistry, Multidisciplinary

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Abhijit A. Date et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Review Biotechnology & Applied Microbiology

Engineered Viruses as Genome Editing Devices

Xiaoyu Chen et al.

MOLECULAR THERAPY (2016)

Review Nanoscience & Nanotechnology

pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents

Mahdi Karimi et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8

Ankur Gautam et al.

SCIENTIFIC REPORTS (2016)

Article Nanoscience & Nanotechnology

Activable Cell-Penetrating Peptide Conjugated Prodrug for Tumor Targeted Drug Delivery

Hong Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Article Biochemical Research Methods

Enzyme-Activatable Cell-Penetrating Peptides through a Minimal Side Chain Modification

Saskia A. Bode et al.

BIOCONJUGATE CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Novel cell-penetrating peptide targeting mitochondria

Carmine Pasquale Cerrato et al.

FASEB JOURNAL (2015)

Article Chemistry, Multidisciplinary

Control of polymeric nanoparticle size to improve therapeutic delivery

John W. Hickey et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

Article Chemistry, Multidisciplinary

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

Qian Zhang et al.

ACS NANO (2014)

Article Biochemistry & Molecular Biology

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

Ziqing Qian et al.

BIOCHEMISTRY (2014)

Article Engineering, Biomedical

Long-term efficient gene delivery using polyethylenimine with modified Tat peptide

Seiichi Yamano et al.

BIOMATERIALS (2014)

Article Chemistry, Multidisciplinary

In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides

Roy Weinstain et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

Activatable Cell Penetrating Peptide-Peptide Nucleic Acid Conjugate via Reduction of Azobenzene PEG Chains

Soo Hyeon Lee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Clinical Neurology

Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss

Markus Suckfuell et al.

OTOLOGY & NEUROTOLOGY (2014)

Review Pharmacology & Pharmacy

Fusion protein linkers: Property, design and functionality

Xiaoying Chen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Engineering, Biomedical

A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system

Qianyu Zhang et al.

BIOMATERIALS (2013)

Article Biophysics

Membrane Permeability of Hydrocarbon-Cross-Linked Peptides

Tzu-Lin Sun et al.

BIOPHYSICAL JOURNAL (2013)

Article Pharmacology & Pharmacy

Cell-penetrating Peptides as Nucleic Acid Delivery Systems: From Biophysics to Biological Applications

Sara Trabulo et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Pharmacology & Pharmacy

PepFect15, a novel endosomolytic cell-penetrating peptide for oligonucleotide delivery via scavenger receptors

Staffan Lindberg et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Article Chemistry, Multidisciplinary

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

Erlei Jin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Multidisciplinary Sciences

Family of pH (low) insertion peptides for tumor targeting

Dhammika Weerakkody et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Chemistry, Multidisciplinary

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

Erkki Ruoslahti

ADVANCED MATERIALS (2012)

Article Chemistry, Multidisciplinary

Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes

Morten B. Hansen et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Biochemistry & Molecular Biology

Transtumoral targeting enabled by a novel neuropilin-binding peptide

L. Roth et al.

ONCOGENE (2012)

Review Chemistry, Medicinal

Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges

Alfredo Erazo-Oliveras et al.

PHARMACEUTICALS (2012)

Article Chemistry, Multidisciplinary

Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

Vikash P. Chauhan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Chemistry, Multidisciplinary

Cell-Penetrating Homochiral Cyclic Peptides as Nuclear-Targeting Molecular Transporters

Deendayal Mandal et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Engineering, Biomedical

Light induced drug delivery into cancer cells

Yosi Shamay et al.

BIOMATERIALS (2011)

Article Biochemistry & Molecular Biology

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

Bidisha Sinha et al.

Article Biochemistry & Molecular Biology

Effects of Intracellular Superoxide Removal at Acupoints with TAT-SOD on Obesity

Jingke Guo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Chemistry, Multidisciplinary

Endosomal escape pathways for delivery of biologicals

Amir K. Varkouhi et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Biochemistry & Molecular Biology

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Kariem Ezzat et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Pharmacology & Pharmacy

In vitro identification of targeting ligands of human M cells by phage display

V. Fievez et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Article Biochemistry & Molecular Biology

Parallel in Vivo and in Vitro Selection Using Phage Display Identifies Protease-dependent Tumor-targeting Peptides

Mike Whitney et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biotechnology & Applied Microbiology

Effect of Genome Size on AAV Vector Packaging

Zhijian Wu et al.

MOLECULAR THERAPY (2010)

Article Multidisciplinary Sciences

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

Quyen T. Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemical Research Methods

Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

Sachiko Kobayashi et al.

BIOCONJUGATE CHEMISTRY (2009)

Article Oncology

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

Kazuki N. Sugahara et al.

CANCER CELL (2009)

Review Chemistry, Multidisciplinary

Nonviral Vectors for Gene Delivery

Meredith A. Mintzer et al.

CHEMICAL REVIEWS (2009)

Review Pharmacology & Pharmacy

Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers

Vladimir P. Torchilin

ADVANCED DRUG DELIVERY REVIEWS (2008)

Article Chemistry, Multidisciplinary

HIV TAT forms pores in membranes by inducing saddle-splay curvature: Potential role of bidentate hydrogen bonding

Abhijit Mishra et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Chemistry, Multidisciplinary

Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance

Eun Seong Lee et al.

JOURNAL OF CONTROLLED RELEASE (2008)

Review Biotechnology & Applied Microbiology

Protein therapeutics: A summary and pharmacological classification

Benjamin Leader et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Nanoscience & Nanotechnology

Nanocarriers as an emerging platform for cancer therapy

Dan Peer et al.

NATURE NANOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview

R. Abes et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Biophysics

Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers

Lindsay E. Yandek et al.

BIOPHYSICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

Inhibition by tyroserleutide (YSL) on the invasion and adhesion of the mouse melanoma cell

Zhi Yao et al.

MOLECULAR MEDICINE (2007)

Article Engineering, Biomedical

Design of modular non-viral gene therapy vectors

L De Laporte et al.

BIOMATERIALS (2006)

Review Pharmacology & Pharmacy

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

WJ Li et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

Article Biochemistry & Molecular Biology

Endocytosis by random initiation and stabilization of clathrin-coated pits

M Ehrlich et al.

Article Multidisciplinary Sciences

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

T Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biotechnology & Applied Microbiology

Sendai virus vectors as an emerging negative-strand RNA viral vector system

M Bitzer et al.

JOURNAL OF GENE MEDICINE (2003)

Review Neurosciences

Viral vectors for gene delivery to the nervous system

BL Davidson et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Article Chemistry, Multidisciplinary

pH-sensitive polymers that enhance intracellular drug delivery in vivo

TR Kyriakides et al.

JOURNAL OF CONTROLLED RELEASE (2002)

Review Biochemistry & Molecular Biology

Mode of action of membrane active antimicrobial peptides

Y Shai

BIOPOLYMERS (2002)

Article Biotechnology & Applied Microbiology

A peptide carrier for the delivery of biologically active proteins into mammalian cells

MC Morris et al.

NATURE BIOTECHNOLOGY (2001)

Article Multidisciplinary Sciences

The many ways to cross the plasma membrane

DJ Stephens et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)