4.7 Article

Therapeutic Potential of BMP7 in the Treatment of Osteoporosis Caused by the Interaction between Inflammation and Corticosteroids in Inflammatory Bowel Disease

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Epidemiology of Inflammatory Bowel Diseases: A Population Study in a Healthcare District of North-West Italy

Gian Paolo Caviglia et al.

Summary: This study investigated the clinical characteristics and epidemiological changes of inflammatory bowel diseases (IBD) in the Healthcare District Bra. The prevalence and incidence of IBD have increased significantly over the past two decades, highlighting the need for specific interventions to improve patient management and resource allocation.

JOURNAL OF CLINICAL MEDICINE (2023)

Article Nutrition & Dietetics

Risk Factors for Osteoporosis among Patients with Inflammatory Bowel Disease-Do We Already Know Everything?

Konrad Lewandowski et al.

Summary: This study assessed the frequency and risk factors of osteoporosis (OST) among patients with inflammatory bowel disease (IBD) compared to a group without IBD. It found that 7.3% of IBD patients suffered from OST. Factors such as male gender, ulcerative colitis, rare physical activity, past fractures, and abnormal levels of certain biomarkers were identified as risk factors for OST in IBD patients. The study highlights the importance of regular physical activity and the use of biomarkers in diagnosing and managing OST in IBD patients.

NUTRIENTS (2023)

Review Biochemistry & Molecular Biology

Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease

Brunette Katsandegwaza et al.

Summary: This article reviews the current murine models used for studying human inflammatory bowel disease, including chemical-induced models, gene-deficient models, and cell transfer models. The application and limitations of these models in understanding the disease pathogenesis and developing new clinical treatment strategies are discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Ophthalmology

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves' Orbitopathy

Bo Yi Kim et al.

Summary: This study aimed to investigate the role of bone morphogenic protein 7 (BMP7) in the pathogenic mechanism of Graves' orbitopathy (GO). The results showed that BMP7 mRNA levels were lower in GO orbital tissues compared to normal control tissues. Treatment with recombinant human BMP7 (rhBMP7) suppressed the production of fibrosis-related proteins and pro-inflammatory cytokines in orbital fibroblasts. These findings suggest that BMP7 has potential therapeutic effects by counteracting the profibrotic TGF-beta/SMAD signaling and proinflammatory cytokine production.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

Review Cell Biology

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Xuebing Han et al.

Summary: Macrophages in the intestinal tract play a crucial role in maintaining microbial homeostasis and renewing intestinal epithelial cells, as well as participating in the development of intestinal inflammation. Understanding their functions and roles in inflammatory responses will be crucial for advancing treatments of intestinal inflammatory diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Medicine, General & Internal

Treatment of Inflammatory Bowel Disease: A Comprehensive Review

Zhaobei Cai et al.

Summary: Inflammatory bowel disease (IBD) is a global disease that has attracted significant research interest. Constant research has led to a better understanding of the disease and promoted the development of conventional and novel treatments. From small molecules to cell therapy, diverse therapeutic options are emerging, offering new hope for treating IBD.

FRONTIERS IN MEDICINE (2021)

Review Immunology

Biology and therapeutic potential of interleukin-10

Margarida Saraiva et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Immunology

IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology

Hua-Xing Wei et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Pharmacology & Pharmacy

Gut-derived serotonin contributes to bone deficits in colitis

B. Lavoie et al.

PHARMACOLOGICAL RESEARCH (2019)

Review Medicine, Research & Experimental

Bone morphogenetic protein signaling in inflammation

David H. Wu et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Surgery

Inflammatory Bowel Disease Presentation and Diagnosis

Sean Flynn et al.

SURGICAL CLINICS OF NORTH AMERICA (2019)

Review Immunology

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

Qingdong Guan

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

Review Endocrinology & Metabolism

Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy

Rowan S. Hardy et al.

ENDOCRINE REVIEWS (2018)

Article Medicine, Research & Experimental

The effects of dihydroartemisinin on inflammatory bowel disease-related bone loss in a rat model

Xingtao Ge et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2018)

Review Gastroenterology & Hepatology

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

Sozaburo Ihara et al.

JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease

Marcus Harbord et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Multidisciplinary Sciences

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

Crystal Rocher et al.

PLOS ONE (2013)

Review Endocrinology & Metabolism

Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives

Markus J. Seibel et al.

LANCET DIABETES & ENDOCRINOLOGY (2013)

Article Gastroenterology & Hepatology

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

Ivana Maric et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Pharmacology & Pharmacy

Bone morphogenetic protein 7 polarizes THP-1 cells into M2 macrophages

Crystal Rocher et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2012)

Article Gastroenterology & Hepatology

Dynamic progress of 2,4,6-trinitrobenzene sulfonic acid induced chronic colitis and fibrosis in rat model

Mei Ying Zhu et al.

JOURNAL OF DIGESTIVE DISEASES (2012)

Review Immunology

Mucosal Macrophages in Intestinal Homeostasis and Inflammation

Allan McI Mowat

JOURNAL OF INNATE IMMUNITY (2011)

Review Cell Biology

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

Agnes E. Coutinho et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Review Medicine, General & Internal

Osteoporosis in Inflammatory Bowel Disease

Tauseef Ali et al.

AMERICAN JOURNAL OF MEDICINE (2009)

Article Pharmacology & Pharmacy

The bisphosphonate alendronate improves the damage associated with trinitrobenzenesulfonic acid-induced colitis in rats

I. Ballester et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Gastroenterology & Hepatology

The RANKL/OPG system and bone mineral density in patients with chronic liver disease

AR Moschen et al.

JOURNAL OF HEPATOLOGY (2005)

Review Biochemistry & Molecular Biology

Bone morphogenetic proteins in development and homeostasis of kidney

P Simic et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2005)

Article Developmental Biology

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

HY Chen et al.

DEVELOPMENT (2004)

Article Pharmacology & Pharmacy

Effects of tumour necrosis factor-α synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis

C Bobin-Dubigeon et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2001)