4.7 Review

The RELT Family of Proteins: An Increasing Awareness of Their Importance for Cancer, the Immune System, and Development

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms

Wenjuan Mei et al.

Journal of Advanced Research (2023)

Article Genetics & Heredity

Whole-genome selective scans detect genes associated with important phenotypic traits in goat (Capra hircus)

Xing Wan et al.

Summary: This study used whole-genome resequencing data to investigate goat breeds with outstanding traits and identified 210-531 genomic regions related to six economic phenotypic traits. The study discovered both previously reported genes and novel genes associated with these traits. It provides new genetic markers for genetic improvement in goats and insights into the genetic mechanisms of complex traits.

FRONTIERS IN GENETICS (2023)

Article Medicine, Research & Experimental

High-throughput proteomic analysis reveals systemic dysregulation in virally suppressed people living with HIV

Nadira Vadaq et al.

Summary: HIV-infected individuals receiving antiretroviral therapy exhibit dysregulation of immune and microbial profiles, leading to cardiovascular disease development. Certain proteins were found to be associated with the presence and risk of cardiovascular disease in HIV patients.

JCI INSIGHT (2023)

Article Genetics & Heredity

DHX38 restricts chemoresistance by regulating the alternative pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma

Zeru Li et al.

Summary: The study identified a new intron retention gene in pancreatic ductal adenocarcinoma, which is regulated by the upstream splicer DHX38. The reduction of DHX38 expression leads to the retention of the fourth intron of RELL2, causing nonsense-mediated mRNA decay and inhibiting apoptosis of pancreatic cancer cells, ultimately promoting drug resistance. This research provides a potential therapeutic target for pancreatic ductal adenocarcinoma.

PLOS GENETICS (2023)

Article Cell Biology

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

Huaiming Sang et al.

Summary: This study identifies the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in gastric cancer, providing a promising novel diagnostic circulating biomarker and therapeutic target in gastric cancer.

CELL DEATH & DISEASE (2022)

Article Genetics & Heredity

Zebrafish information network, the knowledgebase for Danio rerio research

Yvonne M. Bradford et al.

Summary: The Zebrafish Information Network is a central repository for genetic and genomic data of Danio rerio, providing services for the zebrafish research community. It makes zebrafish research data accessible and integrable through various activities and tools, and collaborates with other model organism knowledgebases for data integration.

GENETICS (2022)

Article Genetics & Heredity

ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta

Simone Johansen et al.

Summary: The transcription factor ZBED1 is highly expressed in trophoblast cells and may play important roles in placental biology, including maintaining a steady pool of cytotrophoblast cells, regulating trophoblast cell survival and apoptosis, and modulating maternal immune tolerance.

GENES (2022)

Article Biotechnology & Applied Microbiology

Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis

Kadeerjiang Musha et al.

Summary: This study found that RELL2 is highly expressed in cancer and is associated with poor prognosis in many cancers. RELL2 expression is significantly associated with tumor microenvironment, MSI, and TMB, as well as the expression profiles of immune neoantigens and immune checkpoint genes. The results suggest that RELL2 may serve as a prognostic biomarker in pan-cancer.

DISEASE MARKERS (2022)

Review Cell Biology

Human topoisomerases and their roles in genome stability and organization

Yves Pommier et al.

Summary: Human topoisomerases are a family of six enzymes that play essential roles in transcription, DNA replication, chromatin remodeling, and genome organization. However, they can also cause genomic damage, leading to neurological diseases and cancer.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Psychiatry

The Vulnerability to Methamphetamine Dependence and Genetics: A Case-Control Study Focusing on Genetic Polymorphisms at Chromosomal Region 5q31.3

Jing Xiao et al.

Summary: In this study, the contribution of HDAC3 to the vulnerability to METH dependence in the Han Chinese population was investigated. The results showed that the genetic polymorphism rs14251 located at 5q31.3 was significantly associated with the vulnerability to METH dependence.

FRONTIERS IN PSYCHIATRY (2022)

Article Cardiac & Cardiovascular Systems

Association of Circulating Cathepsin B Levels With Blood Pressure and Aortic Dilation

Tianci Chai et al.

Summary: This study identified the association between circulating cathepsin B and blood pressure (BP) and aortic diameters, suggesting that BP-associated genetic variants may influence the risk of aortic dilation through circulating proteins that regulate BP.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Oncology

KCNN4 may weaken anti-tumor immune response via raising Tregs and diminishing resting mast cells in clear cell renal cell carcinoma

Yankang Cui et al.

Summary: This study is the first to assess the prognostic value of immune-related ceRNA hub genes in ccRCC, and KCNN4 has been demonstrated as a key regulatory factor strongly correlated with Tregs and mast cells resting.

CANCER CELL INTERNATIONAL (2022)

Article Chemistry, Medicinal

Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential

Jifa Zhang et al.

Summary: PLK1 plays an important role in cellular functions and is associated with cancer prognosis and cell proliferation. Although several inhibitors have entered clinical trials, their poor specificity has hindered their development. Recent research has discovered PLK1 inhibitors with higher selectivity and improved characteristics. This review emphasizes the structure-activity relationships of these inhibitors, providing insights for the development of antitumor drugs.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Agriculture, Dairy & Animal Science

cd26 Knockdown Negatively Affects Porcine Parthenogenetic Preimplantation Embryo Development

In-Sul Hwang et al.

Summary: This study highlights the important role of the cd26 gene in the in vitro development of porcine pre-implantation embryos. By using cd26 siRNA, the expression of cd26 was inhibited and resulted in impaired blastocyst development in the porcine embryos. Additionally, the cd26 siRNA-treated blastocysts showed increased apoptotic cells and altered gene expression patterns related to apoptosis, accumulation of reactive oxygen species, and ribosomal protein genes.

ANIMALS (2022)

Article Biology

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Sara E. Vazquez et al.

Summary: Phage immunoprecipitation sequencing (PhIP-seq) is a unbiased method for discovering autoantibodies and studying immune dysregulation in various diseases. This study developed and validated a high throughput extension of PhIP-seq, which can be applied to autoimmune and inflammatory diseases, providing prediction of disease status and detection of autoantigens.

ELIFE (2022)

Article Oncology

Comprehensive analysis of ECHDC3 as a potential biomarker and therapeutic target for acute myeloid leukemia: Bioinformatic analysis and experimental verification

Yijing Zhao et al.

Summary: This study found that high expression of ECHDC3 is associated with poor prognosis and chemoresistance in non-APL AML patients. ECHDC3 can alter the bone marrow microenvironment, inducing differentiation of NK cells, resting mast cells, and monocytes. Knocking down ECHDC3 enhances the sensitivity of cells to chemotherapy drugs.

FRONTIERS IN ONCOLOGY (2022)

Article Genetics & Heredity

A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein

Divya S. Bhat et al.

Summary: BRCA-ness phenotype, a signature of many breast and ovarian cancers, offers opportunities for the development of novel chemotherapeutic interventions. PARP inhibitors have been approved for the treatment of patients with BRCA1/2 mutations, and other targets have been identified for selectively killing BRCA-deficient cancer cells.

DNA REPAIR (2022)

Review Chemistry, Multidisciplinary

WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension

Archie Brown et al.

Summary: Hypertension is a common health issue globally, with Gordon's syndrome being a form of secondary hypertension that may result from mutations in key genes. Treatment for Gordon's syndrome mainly involves the use of thiazide diuretics, but they come with side effects, leading to research efforts focusing on developing novel inhibitory molecules.

ACTA PHARMACOLOGICA SINICA (2021)

Article Biochemistry & Molecular Biology

The mouse Gene Expression Database (GXD): 2021 update

Richard M. Baldarelli et al.

Summary: The Gene Expression Database is a well-curated community resource for mouse developmental gene expression information. It has integrated RNA-Seq data and enhanced searching and filtering capabilities to make the data more accessible for users. Additional tools for display and analysis of RNA-Seq data have been embedded into the user interface for improved visualization and analysis.

NUCLEIC ACIDS RESEARCH (2021)

Article Biotechnology & Applied Microbiology

Identification of Novel Biomarkers for Predicting Prognosis and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma Based on ceRNA Network and Immune Infiltration Analysis

Ya Guo et al.

Summary: This study identified prognostic and IC-related biomarkers in HNSCC patients, constructed two risk signatures, and validated the predictive ability of key ceRNAs for response to ICI therapy.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Cardiac & Cardiovascular Systems

Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure

Lars Lind et al.

Summary: Large-scale proteomics analysis identified over 40 new proteins associated with cardiovascular diseases. Some of these proteins were specifically related to myocardial infarction, ischemic stroke, and heart failure. These findings have the potential to improve risk prediction for CVD in elderly male populations. Further studies are needed to validate these findings in different age groups and genders.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Immunology

Tumor Necrosis Factor Family Member Profile Predicts Prognosis and Adjuvant Chemotherapy Benefit for Patients With Small-Cell Lung Cancer

Zhihui Zhang et al.

Summary: The study provided a comprehensive investigation of TNF family members in small cell lung cancer patients, constructing a TNF family-based signature that could predict prognosis and chemotherapy benefit. The signature exhibited superior predictive performance and was identified as a novel independent prognostic factor, offering a new method for optimizing clinical management for SCLC patients.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Surfaceome Proteomic of Glioblastoma Revealed Potential Targets for Immunotherapy

Melanie Rose et al.

Summary: This study identified potential specific targets for GBM by comparing the surfaceome of GBM and astrocytes cell lines, with 11 specific potential targets identified including 5 mutated proteins. Matching with drug and clinical trials databases revealed that 7 proteins were druggable and under evaluation, providing new insights for immune therapy strategies in GBM.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Genetic factors affect the susceptibility to bacterial infections in diabetes

Johan R. Simonsen et al.

Summary: The common genetic variants on chromosome 2 may be associated with reduced risk of bacterial infections in individuals with diabetes. A specific genetic variant was linked to lower antibiotic purchase rate, indicating its relevance to infection resistance.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

RELT promotes the growth of esophageal squamous cell carcinoma by activating the NF-κB pathway

Wenjian Yao et al.

Summary: The study identified RELT as an oncogene in esophageal squamous cell carcinoma (ESCC) through the NF-kappa B pathway. Overexpression of RELT was found to promote cell growth, inhibit apoptosis, and contribute to tumorigenesis in ESCC.

CELL CYCLE (2021)

Article Genetics & Heredity

Identification of a Costimulatory Molecule-Related Signature for Predicting Prognostic Risk in Prostate Cancer

Shengdong Ge et al.

Summary: Costimulatory molecules have been shown to enhance antitumor immune responses, but their roles in prostate cancer have not been well explored. This study identified five prognosis-related costimulatory molecule genes and constructed a prognostic signature based on these genes. The signature could independently predict prognosis, stratify patients into subgroups, and was well validated in external datasets, providing clinicians with prognosis predictions and treatment guidance for prostate cancer patients.

FRONTIERS IN GENETICS (2021)

Review Biochemistry & Molecular Biology

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

Mohammad Reza Zinatizadeh et al.

Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.

GENES & DISEASES (2021)

Article Genetics & Heredity

New missense variants in RELT causing hypomineralised amelogenesis imperfecta

Georgios Nikolopoulos et al.

CLINICAL GENETICS (2020)

Article Multidisciplinary Sciences

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

Sze Jing Tang et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The p38 Pathway: From Biology to Cancer Therapy

Adrian Martinez-Limon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer

Yuan Sui et al.

SCIENTIFIC REPORTS (2020)

Article Immunology

RELL1, a novel oncogene, accelerates tumor progression and regulates immune infiltrates in glioma

Xiaohong Jin et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

RELT stains prominently in B-cell lymphomas and binds the hematopoietic transcription factor MDFIC

John K. Cusick et al.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2020)

Article Medicine, Research & Experimental

Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer

Panpan Huang et al.

THERANOSTICS (2020)

Article Oncology

Serum biomarker panels for the diagnosis of gastric cancer

Dan Wu et al.

CANCER MEDICINE (2019)

Article Gastroenterology & Hepatology

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Gaelle Angenard et al.

DIGESTIVE AND LIVER DISEASE (2019)

Article Cell Biology

Protective Effect of Ginsenoside Rg1 on Oxidative Damage Induced by Hydrogen Peroxide in Chicken Splenic Lymphocytes

Shicheng Bi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Genetics & Heredity

Mutations in RELT cause autosomal recessive amelogenesis imperfecta

Jung-Wook Kim et al.

CLINICAL GENETICS (2019)

Article Immunology

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes

Andrew R. DiNardo et al.

JOURNAL OF IMMUNOLOGY (2018)

Article Immunology

RELT negatively regulates the early phase of the T-cell response in mice

Beom K. Choi et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Genomic atlas of the human plasma proteome

Benjamin B. Sun et al.

NATURE (2018)

Review Chemistry, Analytical

Autoantibodies as Potential Biomarkers in Breast Cancer

Jingyi Qiu et al.

BIOSENSORS-BASEL (2018)

Article Biochemistry & Molecular Biology

RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1

Pachai Moua et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

p38γ MAPK is required for inflammation-associated colon tumorigenesis

N. Yin et al.

ONCOGENE (2016)

Article Biochemistry & Molecular Biology

Genome wide association study on early puberty in Bos indicus

A. V. Nascimento et al.

GENETICS AND MOLECULAR RESEARCH (2016)

Article Multidisciplinary Sciences

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

Jalaj Gupta et al.

FEBS JOURNAL (2015)

Article Pathology

Chromosome 7q31.1 deletion in myeloid neoplasms

Pasquale Tripputi et al.

HUMAN PATHOLOGY (2014)

Review Immunology

Use of Autoantibodies to Detect the Onset of Breast Cancer

Jerome Lacombe et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

Article Oncology

Targeting autophagy in breast cancer

Paola Maycotte et al.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2014)

Article Immunology

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

Minji Byun et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Cell Biology

Proteomic analysis of apoptotic and oncotic pancreatic acinar AR42J cells treated with caerulein

Jiangtao Chu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)

Article Oncology

TROY (TNFRSF19) Promotes Glioblastoma Survival Signaling and Therapeutic Resistance

Joseph C. Loftus et al.

MOLECULAR CANCER RESEARCH (2013)

Review Biotechnology & Applied Microbiology

Clinical targeting of the TNF and TNFR superfamilies

Michael Croft et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Endocrinology & Metabolism

Autophagy: a targetable linchpin of cancer cell metabolism

Robert D. Leone et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

Article Agriculture, Dairy & Animal Science

A whole-genome association study for pig reproductive traits

S. K. Onteru et al.

ANIMAL GENETICS (2012)

Article Cell Biology

Identification of PLSCR1 as a protein that interacts with RELT family members

John K. Cusick et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

Article Cell Biology

RELT induces cellular death in HEK 293 epithelial cells

John K. Cusick et al.

CELLULAR IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Effective Blockage of Both the Extrinsic and Intrinsic Pathways of Apoptosis in Mice by TAT-crmA

Stefan Krautwald et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

Christopher J. Staples et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Xenbase: gene expression and improved integration

Jeff B. Bowes et al.

NUCLEIC ACIDS RESEARCH (2010)

Review Oncology

Signal integration by JNK and p38 MAPK pathways in cancer development

Erwin F. Wagner et al.

NATURE REVIEWS CANCER (2009)

Review Biochemistry & Molecular Biology

The extrinsic cell death pathway and the elan mortel

D. Wallach et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Oncology

Clinical and molecular responses in lung cancer patients receiving Romidepsin

David S. Schrump et al.

CLINICAL CANCER RESEARCH (2008)

Review Oncology

TNF-mediated inflammatory disease

J. R. Bradley

JOURNAL OF PATHOLOGY (2008)

Article Multidisciplinary Sciences

Transcriptome-based systematic identification of extracellular matrix proteins

Ri-ichiroh Manabe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Oncology

Autoantibodies as potential biomarkers for breast cancer

Li Zhong et al.

BREAST CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

Jun kinase delays caspase-9 activation by interaction with the apoptosome

Thanh H. Tran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Cell Biology

The Ca2+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes

Stella A. Nicolaou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Cell Biology

Genome-wide analysis of SPAK/OSR1 binding motifs

Eric Delpire et al.

PHYSIOLOGICAL GENOMICS (2007)

Review Biochemistry & Molecular Biology

RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases

M. Baud'huin et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biochemistry & Molecular Biology

Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human

Claudia Bossen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

The TNF receptor, BELT, binds SPAK and uses it to mediate p38 and JNK activation

TC Polek et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemistry & Molecular Biology

Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1

JK Cusick et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Oncology

Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

C Nakanishi et al.

NATURE REVIEWS CANCER (2005)

Article Biochemistry & Molecular Biology

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

CF Yu et al.

MOLECULAR CELL (2004)

Review Immunology

NF-kappa B at the crossroads of life and death

M Karin et al.

NATURE IMMUNOLOGY (2002)

Article Biochemistry & Molecular Biology

DR3 regulates negative selection during thymocyte development

ECY Wang et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

AM Johnston et al.

ONCOGENE (2000)

Review Cell Biology

The p38 signal transduction pathway - Activation and function

K Ono et al.

CELLULAR SIGNALLING (2000)