4.7 Article

Effects of Schlemm's Canal Suture Implantation Surgery and Pilocarpine Eye Drops on Trabecular Meshwork Pulsatile Motion

Related references

Note: Only part of the references are listed.
Article Computer Science, Interdisciplinary Applications

Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: Imaging-to-modeling

Alireza Karimi et al.

Summary: This study used X-ray computed tomography and scanning electron microscopy to reconstruct 3D microstructural finite element models of the healthy and glaucoma outflow tissues. The results showed that the primary site of outflow resistance in glaucoma eyes is the trabecular meshwork, while in healthy eyes, it is the juxtacanalicular connective tissue and the inner wall of Schlemm's canal. The glaucoma eyes had thicker trabecular meshwork and juxtacanalicular connective tissue and smaller trabecular space compared to healthy eyes.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2023)

Article Pharmacology & Pharmacy

Glaucoma: Novel antifibrotic therapeutics for the trabecular meshwork

Mengqi Qin et al.

Summary: Glaucoma is a chronic neurodegenerative disease that affects 1% of the world's population, characterized by the loss of retinal ganglion cells and visual field defects. Elevated intraocular pressure (IOP) is a major risk factor and a therapeutic target for hypertensive glaucoma. Fibrosis, characterized by excessive deposition of extracellular matrix components and myofibroblasts, can impair trabecular meshwork (TM) function and contribute to the pathogenesis of glaucoma. This paper provides an overview of current anti-fibrotic therapeutics targeting the TM, including their mechanisms, efficacy, and research progress.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

Article Computer Science, Interdisciplinary Applications

Biomechanics of human trabecular meshwork in healthy and glaucoma eyes via dynamic Schlemm's canal pressurization

Alireza Karimi et al.

Summary: The stiffness of the trabecular meshwork is significantly higher in glaucoma eyes compared to healthy eyes, indicating differences in viscoelastic mechanical behavior. These findings shed light on the mechanical property distinctions in the outflow pathway of healthy and glaucomatous eyes under dynamic loading, potentially serving as a new biomarker for early diagnosis of glaucoma.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2022)

Article Medicine, General & Internal

Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma

Rong Du et al.

Summary: The study revealed that pulsatile trabecular meshwork motion decreased in POAG patients with higher diurnal IOP fluctuation. Measurement of pulsatile TM motion with PhS-OCT may have clinical potential for evaluating diurnal IOP fluctuation.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Cell Biology

Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions

Avinash Soundararajan et al.

Summary: This study investigated the changes in signaling responses in trabecular meshwork (TM) cells subjected to mechanical stretch. The findings indicate that mechanical stretch enhances protein quality control, oxidative damage response, pro-autophagic signal, and induction of anti-apoptotic and survival signaling in TM cells. The study also suggests that increased ceramide and sphingomyelin signaling potentially contribute to increased TM stiffness, while increased phospholipids and diacylglycerol enable cell membrane remodeling and changes in signaling pathways affecting cellular contractility. Overall, this research highlights the mechanistic interplay of macromolecules in achieving mechanotransduction and intraocular pressure regulation in TM cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Ophthalmology

Iris stromal cell nuclei deform to more elongated shapes during pharmacologically-induced miosis and mydriasis

Neda Rashidi et al.

Summary: The study investigated nuclear shape alterations in iris tissue, finding an increase in nuclear aspect ratio after inducing iris deformation through activation of smooth muscles. The findings suggest the potential for using 3D reconstructions in future computational models to study primary angle-closure glaucoma, as they provide more physiologically realistic values compared to 2D projected images. Moreover, the study indicates that iris stromal cells are subjected to a biomechanically active micro-environment during their physiological function in response to ambient light.

EXPERIMENTAL EYE RESEARCH (2021)

Article Ophthalmology

Outcomes of gonioscopy-assisted transluminal trabeculotomy in juvenile-onset primary open-angle glaucoma

Yiwei Wang et al.

Summary: The study demonstrates the effectiveness of GATT for juvenile-onset primary open-angle glaucoma (JOAG), with significant reduction in intraocular pressure and high success rates postoperatively. GATT is not only effective for mild-to-moderate cases, but also for severe cases, achieving a surgical success rate of 79.1%.
Article Medicine, General & Internal

Heart rhythm-synchronized fibrin flap in a glaucoma tube shunt The heartbeat acts as a drainage pump for the aqueous humor: A case report

Hirotaka Tanabe et al.

Summary: Observation of a 69-year-old male with refractory open-angle glaucoma who underwent neodymium-doped yttrium aluminum granet (Nd:YAG) laser surgery and prescription steroidal eyedrops revealed the significant role of the heartbeat as a drainage pump in aqueous humor flow dynamics.

MEDICINE (2021)

Review Ophthalmology

Aqueous outflow regulation-21st century concepts

Murray Johnstone et al.

Summary: The article proposes an integrated model of aqueous outflow control using a pump-conduit system, drawing on physiological regulatory mechanisms to improve care for glaucoma patients. The model focuses on trabecular meshwork distention and recoil, with inlet and outlet valves controlling aqueous flow from Schlemm's canal. The failure of the aqueous outflow pump in glaucoma is attributed to loss of tissue elastance and alterations in ciliary body tension, leading to SC wall apposition and reduced pulsatile aqueous discharge. Monitoring these alterations clinically is challenging, but phase-sensitive OCT offers a noninvasive way to measure pulse-dependent TM motion in humans, providing a novel framework for understanding mechanisms and therapeutic options for glaucoma.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

Review Biochemistry & Molecular Biology

Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma

Shayshadri Mallick et al.

Summary: Glaucoma is characterized by elevated intraocular pressure which can lead to vision loss and eventual blindness, and stem cell transplantation shows promise in repairing trabecular meshwork dysfunction and providing a more direct and effective treatment approach.

BIOMOLECULES (2021)

Article Ophthalmology

Gonioscopy-Assisted Transluminal Trabeculotomy in Younger to Middle-Aged Adults: One-Year Outcomes

Ali Salimi et al.

Summary: The study evaluated the 1-year surgical outcomes of GATT in young to middle-aged patients, finding that the procedure had good efficacy, significant IOP reduction, and relatively high safety profile. Patients diagnosed with glaucoma at ages 18-39 were more likely to achieve surgical success.

OPHTHALMOLOGY GLAUCOMA (2021)

Review Ophthalmology

Microinvasive Glaucoma Surgery: A Review of Schlemm's Canal-Based Procedures

Joanna Konopinska et al.

Summary: This review focuses on microinvasive glaucoma surgery based on Schlemm's canal, highlighting the removal of the trabecular meshwork or increase in tension in the meshwork. The review analyzes the role, anatomy, and physiology of the trabecular meshwork and Schlemm's canal, as well as different microsurgical interventions targeted at increasing aqueous humor outflow in primary open-angle glaucoma.

CLINICAL OPHTHALMOLOGY (2021)

Review Ophthalmology

A review of aqueous outflow resistance and its relevance to microinvasive glaucoma surgery

Nicholas H. Andrew et al.

SURVEY OF OPHTHALMOLOGY (2020)

Article Ophthalmology

The effects of negative periocular pressure on intraocular pressure

C. Ross Ethier et al.

EXPERIMENTAL EYE RESEARCH (2020)

Article Ophthalmology

Deconstructing aqueous humor outflow-The last 50 years

Paul L. Kaufman

EXPERIMENTAL EYE RESEARCH (2020)

Article Multidisciplinary Sciences

Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes

Amir Vahabikashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Ophthalmology

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

Chen Xin et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Review Ophthalmology

Trabecular meshwork stiffness in glaucoma

Ke Wang et al.

EXPERIMENTAL EYE RESEARCH (2017)

Article Ophthalmology

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging

Ke Wang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2017)

Review Ophthalmology

Canaloplasty: Current Value in the Management of Glaucoma

Carlo Cagini et al.

JOURNAL OF OPHTHALMOLOGY (2016)

Article Ophthalmology

Update on Schlemm's Canal Based Procedures

Kaweh Mansouri et al.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY (2015)

Article Ophthalmology

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix

Vijay Krishna Raghunathan et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Biochemical Research Methods

Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

Thu-Mai Nguyen et al.

JOURNAL OF BIOMEDICAL OPTICS (2014)

Article Biochemical Research Methods

Strain estimation in phase-sensitive optical coherence elastography

Brendan F. Kennedy et al.

BIOMEDICAL OPTICS EXPRESS (2012)

Article Ophthalmology

Elastic Modulus Determination of Normal and Glaucomatous Human Trabecular Meshwork

Julie A. Last et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Review Ophthalmology

Understanding the Importance of IOP Variables in Glaucoma: A Systematic Review

Marla B. Sultan et al.

SURVEY OF OPHTHALMOLOGY (2009)