Journal
BIOMEDICINES
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines11102718
Keywords
oral squamous cell carcinoma; SEC61G; prognosis; immune infiltration
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This study investigated the expression and clinical significance of SEC61G in oral squamous cell carcinoma (OSCC). The findings showed a significant correlation between SEC61G expression and clinicopathological characteristics, as well as a worse prognosis in OSCC patients. Moreover, SEC61G expression was also associated with decreased immune infiltration in OSCC patients.
Oral squamous cell carcinoma (OSCC) is a heterogeneous malignancy originating from the oral mucosal epithelium. Detecting novel biomarkers can offer crucial information on disease aggressiveness and expected clinical outcomes for individual patients. SEC61G, an aberrantly expressed gene in various cancers, has been associated with negative clinical outcomes. However, its expression and clinical significance in OSCC is still unclear. In the present study, we investigated the SEC61G expression level in OSCC using bioinformatic and immunohistochemical analyses. Additionally, our findings revealed a significant correlation between SEC61G expression and clinicopathological characteristics, as well as a worse prognosis in OSCC patients. Notably, flow cytometry analysis on patient samples revealed that SEC61G expression was also linked to decreased immune infiltration in OSCC patients. In conclusion, our study provides evidence supporting SEC61G's role as a potential diagnostic, prognostic, and therapeutic marker in OSCC.
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