NEAT1/microRNA 339-5p/SPI1 Axis Feedback Loop Contributes to Osteogenic Differentiation in Acute Suppurative Osteomyelitis in Children

Article Biotechnology & Applied Microbiology

CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression

Mingyi Li et al.

Summary: The study uncovers the role of circ_0001795/miR-339-5p/YAP1 axis in regulating osteogenic differentiation in osteoporosis, suggesting circ_0001795 as a potential therapeutic target.

BIOENGINEERED (2022)

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Article Immunology

Prognostic analysis and validation of diagnostic marker genes in patients with osteoporosis

Xing Wang et al.

Summary: This study identified genes associated with osteoporosis and proposed diagnostic markers using advanced data analysis techniques. The findings have the potential to improve prognosis and shed light on the relationship between the immune microenvironment and osteoporosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer

Yu He et al.

Summary: The study revealed that ESM1 is highly expressed in endometrial cancer and promotes the malignant phenotype of EC by binding with SPI1. Silencing ESM1 inhibited biological processes in EC cells, while overexpression of ESM1 had the opposite effect.

OPEN MEDICINE (2022)

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Article Biochemistry & Molecular Biology

LncRNA NONHSAT009968 inhibits the osteogenic differentiation of hBMMSCs in SA-induced inflammation via Wnt3a

Hongjie Wen et al.

Summary: The study revealed that NONHSAT009968 inhibited the osteogenic differentiation of hBMMSCs under infection through the Wnt3a pathway, which may have affected the occurrence and development of osteomyelitis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

Enhanced expression of KIF4A in osteosarcoma predicts a poor prognosis and facilitates tumor growth by activation of the MAPK pathway

Dongsheng Zhu et al.

Summary: The study revealed that elevated expression of KIF4A in human osteosarcoma tissues was associated with poor prognosis, suggesting it as a potential prognostic marker. Silencing of KIF4A was shown to inhibit osteosarcoma cell proliferation.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Genetics & Heredity

NEAT1 functions as a key mediator of BMP2 to promote osteogenic differentiation of renal interstitial fibroblasts

Zewu Zhu et al.

Summary: NEAT1 plays a key role in the formation of kidney stones by altering the function of osteogenic-like cells in the kidney, contributing to the development of Randall's plaques (RP).

EPIGENOMICS (2021)

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Article Oncology

LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis

Chengqiang Mo et al.

Summary: Prostate cancer cells secrete exosomes containing NEAT1, which influences the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in prostate cancer. NEAT1 shuttled by PCa-derived exosomes can be transferred into hBMSCs and promotes osteogenic differentiation through competitively binding to miR-205-5p and regulating SFPQ/PTBP2 both in vitro and in vivo.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Biology

lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis

Yongfang Zhou et al.

Summary: The study found that in SNFH, lncRNA NEAT1 acts as a molecular sponge to adsorb miR-23b-3p, promoting the expression of CYP1A2, thereby inhibiting the osteogenic differentiation of hBMSCs. Silencing lncRNA NEAT1 and overexpressing miR-23b-3p can partially reverse this effect, further confirming their key roles in the development of SNFH.

OPEN LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology