Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Article Pharmacology & Pharmacy

Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation

Yang Wang et al.

Summary: This study found that quercetin (QCT) can alleviate neutrophilic airway inflammation associated with ferroptosis and inhibit M1 macrophage polarization.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Article Immunology

Regulation of ferroptosis and ACSL4-15LO1 pathway contributed to the anti-asthma effect of acupuncture

Weifeng Tang et al.

Summary: Acupuncture has a long history in China for treating asthma and recent studies have revealed its potential in regulating ferroptosis and airway inflammation. This study found that non-haem Fe2+ levels and lipid peroxidation markers were elevated in an experimental asthma model, while acupuncture treatment reduced inflammation and markers of ferroptosis. The findings suggest that acupuncture may be a potential therapy for attenuating lipid peroxidation and ferroptosis in asthma.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Apelin-13 facilitates mitochondria homeostasis via mitophagy to prevent against airway oxidative injury in asthma

Meixuan Liu et al.

Summary: Oxidative stress plays a significant role in the development of allergen-induced asthma. Studies have shown that Apelin-13, a multifunctional protein, has anti-inflammatory and anti-oxidative properties. However, its role in mitochondria homeostasis under asthma-associated airway oxidative injury and the underlying mechanisms have not been fully understood.

MOLECULAR IMMUNOLOGY (2023)

Add to Collection

Article Plant Sciences

Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway

Hang Yu et al.

Summary: This study found that apigenin, a flavonoid compound, effectively suppressed the complex inflammation in obese asthma, reduced airway hyperresponsiveness, inflammatory cell infiltration, airway epithelial cell apoptosis, airway collagen deposition, and lung oxidative stress via the ROS-ASK1-MAPK pathway. It also clarified the potential therapeutic targets of apigenin in chronic obese asthma and provided new options for its treatment.

PHYTOMEDICINE (2023)

Add to Collection

Letter Allergy

The NLRP3 inflammasome inhibitor, OLT1177®, ameliorates experimental allergic asthma in mice

Lars P. Lunding et al.

ALLERGY (2022)

Add to Collection

Article Cell Biology

Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma

Yuzo Suzuki et al.

Summary: Obesity is a common comorbidity in patients with asthma and obese asthma patients present the most refractory phenotype among patients with severe asthma. This study found that autophagy contributes to the exacerbation of eosinophilic inflammation in obese asthma, and modulation of autophagy may be a therapeutic target in obesity-associated asthma.

AUTOPHAGY (2022)

Add to Collection

Article Allergy

Refractory neutrophilic asthma and ciliary genes

Vamsi P. Guntur et al.

Summary: The study found a ciliary-deficient subgroup in patients with refractory asthma, which may result in repeated asthma exacerbations despite adequate treatment. The findings of this study contribute to further exploration of ciliary function, mechanism, and therapeutics.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma

James W. Pinkerton et al.

Summary: This study investigated the impact of obesity on the pathogenesis and severity of asthma and identified effective therapies for obesity-associated disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die

Natalia Ketelut-Carneiro et al.

Summary: This review discusses the three main types of programmed cell death, apoptosis, pyroptosis, and necroptosis, highlighting their characteristics and commonalities. Understanding the similarities and differences of these cell death processes is crucial for the development of targeted therapeutic strategies.

JOURNAL OF MOLECULAR BIOLOGY (2022)

Add to Collection

Article Plant Sciences

Vitexin restores lung homeostasis by targeting vicious loop between inflammatory aggravation and autophagy mediated via multiple redox cascade and myeloid cells alteration in experimental allergic asthma

Narendra Vijay Tirpude et al.

Summary: The study demonstrates that vitexin can alleviate allergic asthma through regulating oxidative stress, autophagy, and apoptosis. It shows protective effects in various aspects and has a potential therapeutic value.

PHYTOMEDICINE (2022)

Add to Collection

Article Plant Sciences

Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy

Xin Han et al.

Summary: This study found that TGP and PF can improve lung injury in a mouse model of asthma by inhibiting inflammation, regulating immune response, reducing oxidative stress and inhibiting autophagy.

PHYTOMEDICINE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations

Anju Jaiswal et al.

Summary: This study found that intranasal administration of curcumin can reduce asthma exacerbations caused by endotoxin by modulating NLRP3 activation, and it also has anti-inflammatory effects.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

Add to Collection

Article Instruments & Instrumentation

Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation

Emanuela Fabiola Craparo et al.

Summary: This paper details the design and production of a novel formulation of the drug rapamycin based on nano into micro (NiM) particles. The formulation shows promise in the treatment of lung diseases and has good potential for local administration to the lungs.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Add to Collection

Review Cell Biology

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Jian Yang et al.

Summary: New research has shown that the development of osteoarthritis is influenced by different mechanisms of cell death and types of cytokines. Understanding the interaction between cytokines, cell death processes, and osteoarthritis is crucial for better understanding the pathogenesis and progression of the disease.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection

Review Medicine, Research & Experimental

Autophagy in asthma and chronic obstructive pulmonary disease

Peter J. Barnes et al.

Summary: Autophagy is a cellular process that removes damaged molecules and organelles, and abnormalities in autophagy may contribute to the pathogenesis of chronic diseases like asthma and COPD. Autophagy can be either increased or decreased depending on the cell type and environment, making it challenging to target therapeutically. Some existing drugs can activate or inhibit autophagy, but more selective drugs are being developed.

CLINICAL SCIENCE (2022)

Add to Collection

Article Immunology

MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes

Saba Bakhshi et al.

Summary: Evidence suggests that NLRP3 is involved in various inflammatory and autoimmune diseases, and inhibition of NLRP3 can be a useful treatment option. MCC950, a small molecule, can specifically inhibit NLRP3 and reduce the production of proinflammatory cytokines.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis

Qiaoyun Bai et al.

Summary: Sesamin, a natural lignan, may relieve asthma airway inflammation by inhibiting mitochondrial apoptosis and mitophagy.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular allergology approach to allergic asthma

Ioana Agache et al.

Summary: Allergic asthma, a commonly encountered subtype of asthma, lacks precise understanding of its mechanisms and targeted interventions for optimal response. This article explores the potential of molecular allergology approach in achieving better understanding, accurate diagnosis, and optimal management of allergic asthma patients.

MOLECULAR ASPECTS OF MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation

Si Wen et al.

Summary: The study demonstrated that caspase-1-mediated pyroptosis contributes to renal inflammation and fibrosis in diabetic nephropathy. Inhibition of caspase-1 in HK-2 cells effectively alleviates the progression of DN.

JOURNAL OF DIABETES INVESTIGATION (2022)

Add to Collection

Review Pharmacology & Pharmacy

NLRP3 and pyroptosis blockers for treating inflammatory diseases

Rebecca C. Coll et al.

Summary: This article reviews the molecular basis of small molecules under development as novel therapeutics to inhibit NLRP3 inflammasome and summarizes recent strategies to block pyroptosis as a new approach to suppress chronic inflammation. Major recent developments include the elucidation of the mechanisms by which small molecules block NLRP3 inflammasome assembly and GSDMD-induced pyroptosis. The status of clinical trials using agents that block specific components of the NLRP3 pathway and their potential clinical applications for the treatment of many diseases are also discussed.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Add to Collection

Review Cell Biology

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Anqi Li et al.

Summary: Mitophagy is a crucial cellular process that maintains cellular functions by degrading damaged mitochondria. Abnormal mitophagy is closely related to the pathogenesis of many diseases. Dysfunctional mitochondria accumulation plays a significant role in cardiovascular diseases.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Immunology

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

Fan Yang et al.

Summary: This study identified differentially expressed autophagy-related genes and subtypes in asthma patients, showing associations with asthma control, airway inflammation, and immune cell infiltration. A risk prediction model based on autophagy-related genes and asthma control was established and validated, indicating the clinical value of autophagy in the treatment response and prognosis of asthma.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Rapamycin Dampens Inflammatory Properties of Bone Marrow ILC2s in IL-33-Induced Eosinophilic Airway Inflammation

Emma Boberg et al.

Summary: The mTORC1 signaling pathway plays an important role in IL-33-induced bone marrow ILC2 responses, and rapamycin treatment successfully decreases IL-33-induced eosinophilic inflammation, possibly by inhibiting IL-5-producing bone marrow ILC2 cells.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Immunology

Programmed Cell Death Tunes Tumor Immunity

Jing Liu et al.

Summary: Cell death plays a crucial role in modulating the tumor microenvironment and determining the outcomes of cancer therapy. It can have dual roles in promoting or inhibiting tumor growth and also regulates the accumulation of immune cells, contributing to fine-tuning tumor immunity.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Food Science & Technology

Vitamin D ameliorates asthma-induced lung injury by regulating HIF-1α/Notch1 signaling during autophagy

Chaowen Huang et al.

Summary: This study found that vitamin D can suppress asthma-induced lung tissue injury by regulating the HIF-1 alpha/Notch1 signaling pathway, reducing autophagy and cell apoptosis, and improving pathological changes and fibrosis.

FOOD SCIENCE & NUTRITION (2022)

Add to Collection

Review Microbiology

Respiratory Epithelial Cells: More Than Just a Physical Barrier to Fungal Infections

Bianca C. S. C. Barros et al.

Summary: The response of respiratory epithelial cells to fungal pathogens involves complex cellular interactions, including cell signaling, adhesion, invasion, and cytokine secretion.

JOURNAL OF FUNGI (2022)

Add to Collection

Review Allergy

Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins

Chitra Joseph et al.

Summary: Airway remodeling is a complex clinical feature of asthma, which contributes to airway hyperresponsiveness and decline in lung function. It is characterized by thickening of airway smooth muscle layer, subepithelial fibrosis, changes in airway epithelium, excessive mucous production, and angiogenesis. Current asthma treatments do not target airway remodeling, but inhibiting or reversing it has the potential to significantly improve symptoms and disease burden in asthmatic patients. Integrins, a family of transmembrane proteins, play a crucial role in cell-ECM interactions and have emerged as important regulators in inflammation, repair, remodeling, and fibrosis in the asthmatic airway.

JOURNAL OF ASTHMA AND ALLERGY (2022)

Add to Collection

Letter Allergy

Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma

Andong He et al.

ALLERGY (2022)

Add to Collection

Article Immunology

Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis

Chen Bao et al.

Summary: This study investigates the effects of Liproxstatin-1 (Lip-1) on neutrophilic asthma by inhibiting ferroptosis and inflammatory response, and explores the underlying molecular mechanisms.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Pediatrics

Autophagy-related 5 gene mRNA expression and ATG5 rs510432 polymorphism in children with bronchial asthma

Enas Sebaey Ahmad et al.

Summary: This study found that children with asthma have higher levels of ATG5 and that the ATG5 rs510432 gene polymorphism is associated with the development of asthma, with a lower frequency of the CT genotype and a higher frequency of the TT and CC genotypes in asthmatic patients.

PEDIATRIC PULMONOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Mesenchymal stem cells exert their anti-asthmatic effects through macrophage modulation in a murine chronic asthma model

Ruth Lee Kim et al.

Summary: This study aimed to evaluate the anti-asthmatic effects of MSCs primed with Liproxstatin-1 and examine the changes within macrophage populations in asthmatic conditions. The results showed that Liproxstatin-1-primed hUC-MSCs had enhanced ability to downregulate the activation of T helper type 2 cells and reduced airway inflammation and fibrosis in vivo.

SCIENTIFIC REPORTS (2022)

Add to Collection

Review Immunology

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Chunmei Zhang et al.

Summary: This review summarizes the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of ovarian cancer (OC).

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Identification of pyroptosis-related subtypes and establishment of prognostic model and immune characteristics in asthma

Fan Yang et al.

Summary: This study analyzed transcriptome sequencing datasets from patients with different disease courses to identify pyroptosis-related genes (PRGs) and explore their clinical significance in asthma patients. The study found that pyroptosis and its mediated immune phenotype play a crucial role in the occurrence, development, and prognosis of asthma. Diagnostic markers and a risk prediction model were developed to classify asthma subtypes and predict their control level. Additionally, potential therapeutic drugs for asthma were predicted using the cMAP database and molecular docking.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Pediatrics

The role of necroptosis in common respiratory diseases in children

Junjie Ning et al.

Summary: This review explores the possible roles and mechanisms of necroptosis in common respiratory diseases in children, providing new ideas for the prevention and treatment of such diseases.

FRONTIERS IN PEDIATRICS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Multifaceted Roles of Ferroptosis in Lung Diseases

Yi Li et al.

Summary: This review summarizes the contribution of ferroptosis to the pathologic process of lung diseases and discusses its therapeutic potential, which is of great importance for understanding and treating lung diseases.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Add to Collection

Review Medicine, Research & Experimental

Ferroptosis, novel therapeutics in asthma

Xiaodi Lv et al.

Summary: Ferroptosis, an iron-dependent form of regulated cell death closely associated with the immune system, has been shown to have implications in various diseases, including asthma. However, the relationship between ferroptosis and asthma is still fragmented. Further research on the crosslink between asthma inflammation and ferroptosis signaling pathways could identify key molecules that regulate asthma. Understanding the pathogenesis of ferroptosis and its contribution to asthma is crucial for improving prognosis and cure rate of patients.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Review Environmental Sciences

Climatotherapy for asthma: Research progress and prospect

Shilu Tong et al.

Summary: Asthma, affecting over 300 million people globally, is a significant burden, leading to premature death and reduced quality of life. Environmental changes are believed to be the main cause of the rising trend of asthma and other allergic diseases. Therefore, environmental modification plays a crucial role in the treatment and management of asthma, and further research and efforts are needed in this emerging field.

ENVIRONMENTAL RESEARCH (2022)

Add to Collection

Article Immunology

Efficacy and safety of treatment with benralizumab for eosinophilic asthma

Miaojuan Zhu et al.

Summary: This article reviews the findings of recent studies on the treatment of severe eosinophilic asthma with benralizumab, indicating its effectiveness in treating severe asthma.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Cell Biology

Yanghe Pingchuan Granules Alleviate Airway Inflammation in Bronchial Asthma and Inhibit Pyroptosis by Blocking the TLR4/NF-kappa B/NRLP3 Signaling Pathway

Lingyu Pan et al.

Summary: The study demonstrates that Yanghe Pingchuan granules can significantly improve the inflammatory response in a rat model of bronchial asthma by blocking the TLR4/NF-κB signaling pathway and inhibiting pyroptosis factor expression.

MEDIATORS OF INFLAMMATION (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Weitong Gao et al.

Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Article Allergy

Spontaneous sputum discriminates inflammatory phenotypes in patients with asthma

Akihiko Tanaka et al.

Summary: This study investigated the relationship between spontaneous sputum eosinophils and asthma severity. The findings revealed a significant association between high levels of spontaneous sputum eosinophils and severe asthma, emphasizing the importance of assessing airway inflammatory phenotypes in patients with asthma.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

Add to Collection

Article Allergy

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

Xingnan Li et al.

Summary: Multiple SNPs in the gasdermin B (GSDMB) gene are associated with asthma severity and longitudinal asthma exacerbations. Higher expression levels of GSDMB correlate with asthma exacerbations and pathways related to IFN signaling and immune system. GSDMB is identified as a functional gene for both asthma susceptibility and severity.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Allergy

CaMKII oxidation regulates cockroach allergen-induced mitophagy in asthma

Yan Zhang et al.

Summary: The study identified that cockroach allergen activates autophagy, while inhibition of autophagy can mitigate airway hyperresponsiveness and oxidative stress induced by allergic airway inflammation. Furthermore, the research revealed a pathological feedforward circuit between cockroach allergen-induced ROS and autophagy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Review Medicine, Research & Experimental

Challenges and Opportunities of Deferoxamine Delivery for Treatment of Alzheimer's Disease, Parkinson's Disease, and Intracerebral Hemorrhage

Amy Corbin Farr et al.

Summary: Deferoxamine mesylate (DFO) is an iron chelator used to alleviate systemic iron burden in thalassemia major and sickle cell patients, with implications for neurodegenerative diseases. However, limitations such as toxicity at high doses and uncertain ability to cross the BBB have hindered its widespread use. Preclinical evidence suggests promising results in improving behavioral outcomes, but standardized dosing regimens and better understanding of brain DFO concentration following administration are needed for successful clinical translation.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection

Article Medicine, Research & Experimental

Inhibiting ATG5 mediated autophagy to regulate endoplasmic reticulum stress and CD4+ T lymphocyte differentiation: Mechanisms of acupuncture's effects on asthma

Huanyi Zhao et al.

Summary: Acupuncture reduces airway inflammation and AHR in asthma by inhibiting ATG5-mediated autophagy to regulate endoplasmic reticulum stress and CD4(+) T lymphocyte differentiation.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Allergy

Role of autophagy in regulating interleukin-10 and the responses to corticosteroids and statins in asthma

Kittipong Maneechotesuwan et al.

Summary: This study investigated the role of autophagy in promoting inflammation in asthma through reducing IL-10 secretion in macrophages. It found that corticosteroids and statins inhibit autophagy in macrophages, leading to increased IL-10 production and control of asthmatic inflammation.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Add to Collection

Article Cell Biology

Yeast Fermentate Prebiotic Ameliorates Allergic Asthma, Associating with Inhibiting Inflammation and Reducing Oxidative Stress Level through Suppressing Autophagy

Subo Gong et al.

Summary: The research showed that YFP may exert antiasthmatic effects by inhibiting airway allergic inflammation and oxidative stress level through suppressing autophagy.

MEDIATORS OF INFLAMMATION (2021)

Add to Collection

Article Allergy

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment

Natalie M. Niessen et al.

Summary: This study investigated the association between TNF markers and clinical phenotypes of asthma, as well as the effect of azithromycin treatment on these markers. The results showed dysregulation of TNF markers in the airways related to important asthma phenotypes, with azithromycin treatment significantly reducing TNF levels in non-eosinophilic participants.

ALLERGY (2021)

Add to Collection

Article Medicine, Research & Experimental

TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model

Weifeng Tang et al.

Summary: Acupuncture treatment has been shown to effectively alleviate symptoms of asthma by reducing airway hyperresponsiveness, mucus secretion, and inflammation, with mechanisms involving regulation of ferroptosis and specific protein expression pathways.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Review Cell Biology

Programmed cell death in spinal cord injury pathogenesis and therapy

Zhongju Shi et al.

Summary: Spinal cord injury (SCI) leads to functional deterioration due to cell death processes, including programmed cell death (PCD) like apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, and paraptosis. PCD is an active cell death mediated by gene expression events, crucial for eliminating unnecessary and damaged cells and serves as a defense mechanism. Understanding the roles of PCD can enhance our knowledge of pathophysiological processes and improve functional recovery after SCI.

CELL PROLIFERATION (2021)

Add to Collection

Article Chemistry, Medicinal

Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation

Cui-Cui Zhao et al.

Summary: ABA shows efficacy against allergic airway inflammation by inhibiting NLRP3 inflammasome and oxidative stress in a PPAR-gamma dependent manner. This suggests the potential of ABA or ABA-rich food in protecting against asthma.

PHYTOTHERAPY RESEARCH (2021)

Add to Collection

Article Toxicology

Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells

Bo Jiao et al.

Summary: The study demonstrated that autophagy activation in 16HBE cells treated with TDI-HSA could enhance ROS release, Nrf2 expression, airway inflammation, and airway remodeling protein expression, while inhibiting autophagy could alleviate the inflammatory response and attenuate airway remodeling.

TOXICOLOGY IN VITRO (2021)

Add to Collection

Article Medicine, Research & Experimental

Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs

Weifeng Tang et al.

Summary: The translation of previous studies indicated that allergens such as house dust mites can induce allergic asthma. The study used a mouse asthma model to determine the effect of house dust mite exposure on allergic asthma. The results showed an increase in airway hyperresponsiveness, inflammation, mucus secretion, and mitochondrial changes, indicating the involvement of lipid peroxidation and ferroptosis in the pathogenesis of allergic asthma.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Add to Collection

Article Immunology

RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor

Yun Chen et al.

Summary: The study demonstrates that RRx-001 is a highly selective and effective NLRP3 inhibitor, with beneficial effects on various NLRP3-driven inflammatory diseases in mice, including attenuating symptoms of experimental diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex

Shiyuan Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection

Editorial Material Allergy

Role of the NLRP3 inflammasome in asthma: Relationship with neutrophilic inflammation, obesity, and therapeutic options

Evan J. Williams et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Allergy

Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma

Briana N. James et al.

Summary: Elevation of ceramide levels after allergen challenge contributes to features of severe asthma, including apoptosis, reactive oxygen species generation, and neutrophilic infiltrate. Ceramide may be a potential biomarker for monitoring disease progression and optimizing clinical outcomes in severe asthma patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Plant Sciences

Herb pair of Ephedrae Herba-Armeniacae Semen Amarum alleviates airway injury in asthmatic rats

Jia-xin Ma et al.

Summary: The combination of Ephedrae Herba and Armeniacae Semen Amarum can inhibit abnormal changes in airway epithelial structure and apoptosis of airway epithelial cells, thereby alleviating airway injury in asthmatic rats. Among the different groups, the best combination to alleviate airway epithelial injury was group E (EH: ASA = 8: 4.5).

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Article Allergy

PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice

Xiang He et al.

Summary: Experimental findings demonstrate that PM2.5 exacerbates airway inflammation in asthmatic mice by promoting apoptosis and enhancing epithelial mesenchymal transition, leading to disruption of airway epithelial tight junctions.

JOURNAL OF ASTHMA AND ALLERGY (2021)

Add to Collection

Review Immunology

Role of Ferroptosis in Lung Diseases

Wenting Xu et al.

Summary: Ferroptosis is a novel type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, which plays a critical role in various pathological conditions and diseases such as infections, neurodegeneration, and immune diseases.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Add to Collection

Article Chemistry, Multidisciplinary

ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron

Shan Lu et al.

Summary: The study demonstrates that brucine inhibits glioma cell growth and induces ferroptosis by promoting the accumulation of H2O2 and iron via activation of ATF3.

ACTA PHARMACOLOGICA SINICA (2021)

Add to Collection

Article Medicine, Research & Experimental

Qingfei oral liquid inhibited autophagy to alleviate inflammation via mTOR signaling pathway in RSV-infected asthmatic mice

Linlin Yu et al.

Summary: The study found that Qingfei oral liquid can alleviate airway inflammation and mitigate airway hyperresponsiveness in RSV-infected asthmatic mice, potentially through regulating autophagy via the mTOR signaling pathway. This provides new evidence for the application of Qingfei oral liquid in treating asthmatic patients with RSV infection.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Cell Biology

Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis

Xiufeng Chen et al.

Summary: Schisandrin B (SB) has anti-inflammatory and anti-remodeling effects on airways in asthma. It inhibits NLRP3 inflammasome activation and pyroptosis by regulating the miR-135a-5p/TRPC1/STAT3/NF-kappa B axis, thus alleviating airway inflammation and remodeling in asthmatic rats.

INFLAMMATION (2021)

Add to Collection

Article Immunology

miR-20a-5p ameliorates ovalbumin (OVA)-induced mouse model of allergic asthma through targeting ATG7-regulated cell death, fibrosis and inflammation

Yanyan Yu et al.

Summary: MiR-20a-5p plays a role in regulating autophagy through targeting ATG7, affecting airway remodeling and potentially serving as a biomarker and therapeutic target in asthma progression.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection

Editorial Material Allergy

Airway remodeling: Shifting the trigger point for exacerbations in asthma

Tilo Winkler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

Nikos Oikonomou et al.

Summary: Regulation of epithelial cell death plays a key role in controlling immune homeostasis in barrier surfaces. Necroptosis, induced by RIPK3, contributes to inflammatory pathologies in different tissues. Genetic inhibition of RIPK1 kinase activity can prevent the development of exaggerated allergic airway inflammation.

MUCOSAL IMMUNOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950

Sarah E. Corcoran et al.

Summary: Activation of the NLRP3 inflammasome can lead to inflammatory responses and cell death, and is associated with various diseases. Inhibitors of NLRP3 have potential clinical value in preventing the harmful effects of NLRP3 activation on human diseases.

PHARMACOLOGICAL REVIEWS (2021)

Add to Collection

Review Pathology

Mechanisms of Regulated Cell Death: Current Perspectives

Sara Francesca Santagostino et al.

Summary: Balancing cell survival and cell death is crucial for development and homeostasis. Regulated cell death (RCD) is involved in fundamental processes such as organogenesis and tissue remodeling, and recent findings have deepened our understanding of RCD mechanisms. Further research is needed to characterize RCD and its role in disease, beyond traditional terms like apoptosis and necrosis.

VETERINARY PATHOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Autophagy of mucin granules contributes to resolution of airway mucous metaplasia

J. M. Sweeter et al.

Summary: The study found that the autophagy pathway is crucial for the resolution of mucous metaplasia by eliminating excess mucin granules. Deficiency in autophagy regulatory protein can lead to persistent accumulation of mucin granules and impaired resolution of mucous metaplasia. Activation of autophagy in human airway epithelial cells can reduce intracellular mucin granules, suggesting a potential therapeutic target for exacerbations of airway diseases.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Immunology

Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

Ming Ma et al.

Summary: Inhaled allergens promote activation of NLRP3 inflammasome, leading to allergic asthma. The study found that NLRP3 in alveolar macrophages plays a role in promoting the development of allergic asthma through an inflammasome-dependent mechanism. Targeting the NLRP3 inflammasome with small molecules may offer new treatment options for this disease.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Sufang Shui et al.

Summary: The study shows that photodynamic therapy (PDT) can induce lipid peroxidation and cell death similar to ferroptosis, termed as liperoptosis, which is independent of lipoxygenase and ACSL4. Using a clinically approved photosensitizer, PDT effectively inhibits tumor growth through triggering lipid peroxidation and cell death. These findings suggest the potential value of using PDT to induce lipid peroxidation and ferroptosis-like cell death in vivo for cancer treatment and exploring the immunological effects of PDT.

REDOX BIOLOGY (2021)

Add to Collection

Article Cell Biology

An Autophagy Modulator Peptide Prevents Lung Function Decrease and Corrects Established Inflammation in Murine Models of Airway Allergy

Francois Daubeuf et al.

Summary: The study found that autophagy processes are altered in allergic airway inflammation, and can be corrected using drug repositioning techniques.

CELLS (2021)

Add to Collection

Review Medicine, Research & Experimental

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Sheng-Kai Hsu et al.

Summary: New types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, have emerged in recent years, playing significant roles in cancer progression modulation and being closely related to immune regulation in the tumor microenvironment. Pyroptosis, in particular, has been identified as crucial for host defense and bridging innate and adaptive immunity, showing benefits for cancer immunotherapies.

THERANOSTICS (2021)

Add to Collection

Article Respiratory System

SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells

Yuqing Mo et al.

Summary: The study revealed that SERPINB10 plays a crucial role in the survival of Th2 cells in allergic asthma by inhibiting apoptosis, contributing to allergic inflammation and the Th2 response.

RESPIRATORY RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Integrative & Complementary Medicine

Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma

Hui Li et al.

Summary: The study demonstrates that rhynchophylline can alleviate asthma by suppressing autophagy in asthma, while also reducing inflammation, airway remodeling, and oxidative stress. Furthermore, it is suggested that rhynchophylline exerts its effects by inhibiting the JAK2/STAT3 signaling pathway in asthma.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis

Fei Han et al.

Summary: IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. Treatment with Ferrostatin-1 (Fer-1) and antioxidant NAC partially reverses the effects of IL-6 on lipid peroxidation and ferroptosis.

BIOENGINEERED (2021)

Add to Collection

Article Cell Biology

Autophagy induces eosinophil extracellular traps formation and allergic airway inflammation in a murine asthma model

Josiane Silva Silveira et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Allergy

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function

Lauriane Galle-Treger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Add to Collection

Article Critical Care Medicine

Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

Jennifer Simpson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Add to Collection

Letter Biochemistry & Molecular Biology

Pharmacologic Inhibition of Vacuolar H+ATPase Attenuates Features of Severe Asthma in Mice

Kielan D. McAlinden et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma

Michael C Peters et al.

LANCET (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Autophagy and autophagy-related proteins in cancer

Xiaohua Li et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Multidisciplinary Sciences

Caspase-11 promotes allergic airway inflammation

Zbigniew Zaslona et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Medicine, Research & Experimental

Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma

Jian Zhuang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Ting Zhang et al.

CELL (2020)

Add to Collection

Review Public, Environmental & Occupational Health

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab

David J. Jackson et al.

DRUG SAFETY (2020)

Add to Collection

Article Respiratory System

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

Md. Khadem Ali et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Giovanni Miotto et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Medicine, Legal

Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation

Je-Won Ko et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou et al.

SCIENCE (2020)

Add to Collection

Article Respiratory System

Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Jennifer M. Felton et al.

THORAX (2020)

Add to Collection

Article Immunology

Necrostatin-1 Ameliorates Neutrophilic Inflammation in Asthma by Suppressing MLKL Phosphorylation to Inhibiting NETs Release

Xinai Han et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Immunology

IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

Rakhee K. Ramakrishnan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

Jisun Lim et al.

SCIENCE ADVANCES (2020)

Add to Collection

Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

Wojciech Ornatowski et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Environmental Sciences

Respiratory exposure to PM2.5 soluble extract disrupts mucosal barrier function and promotes the development of experimental asthma

Chen Zhao et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Add to Collection

Article Respiratory System

Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation

Yanping Wu et al.

THORAX (2020)

Add to Collection

Review Allergy

Obesity and asthma

Sarah Miethe et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Add to Collection

Review Medicine, General & Internal

Asthma: New Integrative Treatment Strategies for the Next Decades

Diego A. Arteaga-Badillo et al.

MEDICINA-LITHUANIA (2020)

Add to Collection

Article Cell Biology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Junwei Hou et al.

NATURE CELL BIOLOGY (2020)

Add to Collection

Article Pharmacology & Pharmacy

The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma

Jiongbo Wang et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2020)

Add to Collection

Article Respiratory System

MTOR suppresses autophagy-mediated production of IL25 in allergic airway inflammation

Wen Li et al.

THORAX (2020)

Add to Collection

Article Pharmacology & Pharmacy

Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage

Javier Chicote et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients

Rakhee K. Ramakrishnan et al.

PLOS ONE (2020)

Add to Collection

Editorial Material Allergy

Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma?

Youngwoo Choi et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2020)

Add to Collection

Article Allergy

Toll like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Mode

Shuyu Chen et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2020)

Add to Collection

Review Respiratory System

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

Jing Zhang et al.

RESPIRATORY RESEARCH (2020)

Add to Collection

Article Rheumatology

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

Viola Kluck et al.

LANCET RHEUMATOLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma

Da Hye Kim et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Add to Collection

Article Engineering, Biomedical

Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis

Bao-Ping Tian et al.

BIOMATERIALS (2019)

Add to Collection

Article Allergy

Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

Lisa G. Wood et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Pingchuanning decoction attenuates airway inflammation by suppressing autophagy via phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in rat models of asthma

Xinheng Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Article Environmental Sciences

Fine particulate matter (PM2.5) enhances airway hyperresponsiveness (AHR) by inducing necroptosis in BALB/c mice

Yunxia Zhao et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

Add to Collection

Article Allergy

Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects

Elizabeth M. Gordon et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells

Huojun Zhang et al.

LIFE SCIENCES (2019)

Add to Collection

Article Immunology

Downregulated Rac1 promotes apoptosis and inhibits the clearance of apoptotic cells in airway epithelial cells, which may be associated with airway hyper-responsiveness in asthma

Jie Wan et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2019)

Add to Collection

Article Immunology

Inflammasome activation is required for human rhinovirus-induced airway inflammation in naive and allergen-sensitized mice

Mingyuan Han et al.

MUCOSAL IMMUNOLOGY (2019)

Add to Collection

Article Toxicology

Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model

Shuyu Chen et al.

TOXICOLOGICAL SCIENCES (2019)

Add to Collection

Article Chemistry, Medicinal

Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma

Guihua Song et al.

PHYTOTHERAPY RESEARCH (2019)

Add to Collection

Article Medicine, Research & Experimental

Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway

Xingyu Chen et al.

MEDICAL SCIENCE MONITOR (2019)

Add to Collection

Review Oncology

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Ravi K. Amaravadi et al.

CANCER DISCOVERY (2019)

Add to Collection

Article Medicine, General & Internal

The Enhanced Adhesion of Eosinophils Is Associated with Their Prolonged Viability and Pro-Proliferative Effect in Asthma

Andrius Januskevicius et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Add to Collection

Article Medicine, Research & Experimental

Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma

Weiwei Qin et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Article Allergy

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

Hern-Tze Tina Tan et al.

ALLERGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Autophagy Activation in Asthma Airways Remodeling

Kielan D. McAlinden et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Add to Collection

Review Physiology

Cell Death in the Lung: The ApoptosisNecroptosis Axis

Maor Sauler et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

Add to Collection

Review Immunology

Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence

Karan Sachdeva et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Review Medicine, General & Internal

Targeting NLRP3 Inflammasome Activation in Severe Asthma

Efthymia Theofani et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model

Inbar Shlomovitz et al.

FEBS JOURNAL (2019)

Add to Collection

Article Cell Biology

MUC1 downregulation promotes TNF--induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway

Huojun Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Carla Olave et al.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2019)

Add to Collection

Article Critical Care Medicine

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Marrah E. Lachowicz-Scroggins et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Bax, Bak and beyond - mitochondrial performance in apoptosis

Aida Pena-Blanco et al.

FEBS JOURNAL (2018)

Add to Collection

Article Cell Biology

IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma

Fucan Xia et al.

AUTOPHAGY (2018)

Add to Collection

Article Cell Biology

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe et al.

AUTOPHAGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

Yubin Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Add to Collection

Article Allergy

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

Christos Rossios et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Add to Collection

Article Allergy

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

Ronald A. Panganiban et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Add to Collection

Article Immunology

Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice

Chao Huang et al.

JOURNAL OF AUTOIMMUNITY (2018)

Add to Collection

Review Biotechnology & Applied Microbiology

Targeting the NLRP3 inflammasome in inflammatory diseases

Matthew S. J. Mangan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Add to Collection

Article Respiratory System

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response

Jae Seok Jeong et al.

THORAX (2018)

Add to Collection

Article Multidisciplinary Sciences

Interferon-β deficiency at asthma exacerbation promotes MLKL mediated necroptosis

Samuel C. Cerps et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Review Immunology

Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma

Benjamin P. Hurrell et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Allergy

Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma

D. L. Pham et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

Add to Collection

Article Respiratory System

Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma

Wen Gu et al.

RESPIROLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular control of chaperone-mediated autophagy

Steve Catarino et al.

SIGNALLING MECHANISMS IN AUTOPHAGY (2017)

Add to Collection

Article Allergy

Bcl-2 inhibitors reduce steroid-insensitive airway inflammation

Bao-ping Tian et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Add to Collection

Article Allergy

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

Susanne Radonjic-Hoesli et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Add to Collection

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Add to Collection

Review Neurosciences

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

Jesse S. Kerr et al.

TRENDS IN NEUROSCIENCES (2017)

Add to Collection

Article Pharmacology & Pharmacy

Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice

Xue Liu et al.

FRONTIERS IN PHARMACOLOGY (2017)

Add to Collection

Article Immunology

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics

Audrey H. Poon et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

Matthew Redmann et al.

REDOX BIOLOGY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Omkar Zilka et al.

ACS CENTRAL SCIENCE (2017)

Add to Collection

Article Multidisciplinary Sciences

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

Fawaz Awad et al.

PLOS ONE (2017)

Add to Collection

Article Multidisciplinary Sciences

Activation of the mTOR signaling pathway is required for asthma onset

Yanli Zhang et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel et al.

CELL (2017)

Add to Collection

Article Critical Care Medicine

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma

Richard Y. Kim et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Add to Collection

Article Physiology

Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma

Tian Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Add to Collection

Article Medicine, Research & Experimental

Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma

Sara C. Sebag et al.

JCI INSIGHT (2017)

Add to Collection

Article Allergy

Efficacy of parthenolide on lung histopathology in a murine model of asthma

Z. Ankan-Ayyildiz et al.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2017)

Add to Collection

Article Cell Biology

IL13 activates autophagy to regulate secretion in airway epithelial cells

John D. Dickinson et al.

AUTOPHAGY (2016)

Add to Collection

Article Allergy

Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target

G. -Y. Ban et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Add to Collection

Article Allergy

Lack of autophagy induces steroid-resistant airway inflammation

Yuzo Suzuki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Add to Collection

Article Immunology

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Michael J. Primiano et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Oncology

In Brief: Mitophagy: mechanisms and role in human disease

Maya Z. Springer et al.

JOURNAL OF PATHOLOGY (2016)

Add to Collection

Article Oncology

Investigation of the anti-asthmatic activity of Oridonin on a mouse model of asthma

Jing Wang et al.

MOLECULAR MEDICINE REPORTS (2016)

Add to Collection

Article Multidisciplinary Sciences

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Robin A. Aglietti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Multidisciplinary Sciences

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Sudipta Das et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Medicine, General & Internal

Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

Duy Le Pham et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2016)

Add to Collection

Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

The role of autophagy in allergic inflammation: a new target for severe asthma

Jing-Nan Liu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Add to Collection

Article Critical Care Medicine

Toward Primary Prevention of Asthma Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma

Amy S. Feldman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Add to Collection

Article Pharmacology & Pharmacy

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

Satoru Kobayashi

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

Add to Collection

Review Multidisciplinary Sciences

Necroptosis and its role in inflammation

Manolis Pasparakis et al.

NATURE (2015)

Add to Collection

Review Physiology

Neutrophils in asthma-A review

Olga Ciepiela et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2015)

Add to Collection

Article Respiratory System

Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice

Wen Hua et al.

RESPIROLOGY (2015)

Add to Collection

Article Cell Biology

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

Fahima Madouri et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2015)

Add to Collection

Article Respiratory System

Astragalin inhibits autophagy-associated airway epithelial fibrosis

In-Hee Cho et al.

RESPIRATORY RESEARCH (2015)

Add to Collection

Review Cell Biology

Regulated Cell Death: Signaling and Mechanisms

Avi Ashkenazi et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Add to Collection

Review Pharmacology & Pharmacy

Eosinophil Apoptosis as a Therapeutic Target in Allergic Asthma

Pinja Ilmarinen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

Add to Collection

Article Immunology

Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1β during acute allergic airway inflammation

M. Ritter et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)

Add to Collection

Article Respiratory System

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

Jodie L. Simpson et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Add to Collection

Article Immunology

B Cell-Intrinsic MyD88 Signaling Is Essential for IgE Responses in Lungs Exposed to Pollen Allergens

Kazufumi Matsushita et al.

JOURNAL OF IMMUNOLOGY (2014)

Add to Collection

Article Public, Environmental & Occupational Health

Asian Dust and Daily Emergency Ambulance Calls Among Elderly People in Japan An Analysis of Its Double Role as a Direct Cause and as an Effect Modifier

Saori Kashima et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Staying Alive: Cell Death in Antiviral Immunity

Jason W. Upton et al.

MOLECULAR CELL (2014)

Add to Collection

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

Hye Young Kim et al.

NATURE MEDICINE (2014)

Add to Collection

Review Cell Biology

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden Berghe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Add to Collection

Review Respiratory System

Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?

Domokos Bartis et al.

THORAX (2014)

Add to Collection

Article Cell Biology

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

S. R. Kim et al.

CELL DEATH & DISEASE (2014)

Add to Collection

Article Biology

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J. Dixon et al.

ELIFE (2014)

Add to Collection

Article Allergy

Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children

M. I. Muniz-Junqueira et al.

ALLERGY (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

Kathy Triantafilou et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Add to Collection

Article Allergy

Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children

Agnes Hamzaoui et al.

JOURNAL OF ASTHMA (2013)

Add to Collection

Article Immunology

Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells

Louisa J. Mathias et al.

JOURNAL OF IMMUNOLOGY (2013)

Add to Collection

Article Infectious Diseases

Interferon-β induces a long-lasting antiviral state in human respiratory epithelial cells

Giel R. Gaajetaan et al.

JOURNAL OF INFECTION (2013)

Add to Collection

Article Multidisciplinary Sciences

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

Ignacio J. Juncadella et al.

NATURE (2013)

Add to Collection

Review Biochemistry & Molecular Biology

The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

Gethin J. McBean

AMINO ACIDS (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

Add to Collection

Article Allergy

Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis

Rebecca N. Bauer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Add to Collection

Letter Allergy

Genetic and histologic evidence for autophagy in asthma pathogenesis

Audrey H. Poon et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Add to Collection

Article Immunology

Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice

Irving C. Allen et al.

JOURNAL OF IMMUNOLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma

Lisa J. Martin et al.

PLOS ONE (2012)

Add to Collection

Article Multidisciplinary Sciences

Paradoxical Effects of Rapamycin on Experimental House Dust Mite-Induced Asthma

Karin Fredriksson et al.

PLOS ONE (2012)

Add to Collection

Article Cell Biology

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

N. Takahashi et al.

CELL DEATH & DISEASE (2012)

Add to Collection

Article Allergy

Epithelial Apoptosis and Loss in Airways of Children with Asthma

Chunju Zhou et al.

JOURNAL OF ASTHMA (2011)

Add to Collection

Article Multidisciplinary Sciences

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

William J. Kaiser et al.

NATURE (2011)

Add to Collection

Article Immunology

Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro

P.-C. TAI et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

BEDSIDE TO BENCH The emerging epithelium

Clare M. Lloyd et al.

NATURE MEDICINE (2010)

Add to Collection

Editorial Material Respiratory System

Live and let die: is neutrophil apoptosis defective in severe asthma?

Helen Parfrey et al.

THORAX (2010)

Add to Collection

Article Respiratory System

Prosurvival activity for airway neutrophils in severe asthma

Mohib Uddin et al.

THORAX (2010)

Add to Collection

Article Allergy

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma

Yuki Hitomi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Add to Collection

Article Immunology

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

Mariola Kurowska-Stolarska et al.

JOURNAL OF IMMUNOLOGY (2009)

Add to Collection

Article Allergy

12/15-lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

Amanda R. Hajek et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

Add to Collection

Article Cell Biology

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

Taichi Hara et al.

JOURNAL OF CELL BIOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

Mathieu J. M. Bertrand et al.

MOLECULAR CELL (2008)

Add to Collection

Article Multidisciplinary Sciences

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Stephanie C. Eisenbarth et al.

NATURE (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of RIP1 kinase as a specific cellular target of necrostatins

Alexei Degterev et al.

NATURE CHEMICAL BIOLOGY (2008)

Add to Collection

Review Cell Biology

Autophagic cell death: the story of a misnomer

Guido Kroemer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Add to Collection

Article Critical Care Medicine

Epithelial damage and angiogenesis in the airways of children with asthma

Angelo Barbato et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Add to Collection

Article Allergy

Induced apoptosis of TH2 lymphocytes in asthmatic children treated with Dermatophagoides pteronyssinus immunotherapy

YG Tsai et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2005)

Add to Collection

Article Immunology

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

J Schmitz et al.

IMMUNITY (2005)

Add to Collection

Article Respiratory System

Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma

JP Lamb et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

A Degterev et al.

NATURE CHEMICAL BIOLOGY (2005)

Add to Collection

Article Immunology

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

PAB Wark et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Add to Collection

Article Allergy

Creola bodies in wheezing infants predict the development of asthma

Y Yamada et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2004)

Add to Collection

Article Pharmacology & Pharmacy

Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation

AQ Truong-Tran et al.

BIOCHEMICAL PHARMACOLOGY (2003)

Add to Collection

Review Biochemistry & Molecular Biology

Glucocorticoid-induced apoptosis in human eosinophils:: Mechanisms of action

A Druilhe et al.

APOPTOSIS (2003)

Add to Collection

Article Respiratory System

Reduced eosinophil apoptosis in induced sputum correlates with asthma severity

CJA Duncan et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

Add to Collection

Article Critical Care Medicine

Apoptosis of airway epithelial cells induced by corticosteroids

DR Dorscheid et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Add to Collection

Letter Biochemistry & Molecular Biology

Pro-inflammatory programmed cell death

BT Cookson et al.

TRENDS IN MICROBIOLOGY (2001)

Add to Collection

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Related references