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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Diagnosis and Management of Dementia: Review
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)
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FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
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SCIENTIFIC REPORTS (2019)
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AGING CELL (2019)
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PATHOGENS (2019)
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Yanqiu Liu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
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Qing Liu et al.
JOURNAL OF NEUROINFLAMMATION (2019)
Hypertonic saline maintains coagulofibrinolytic homeostasis following moderate-to-severe traumatic brain injury by regulating monocyte phenotype via expression of lncRNAs
Xiping Yang et al.
MOLECULAR MEDICINE REPORTS (2019)
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Vivek Swarup et al.
NATURE MEDICINE (2019)
Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer's disease via C/EBPα/miR-125b pathway
Hui Tang et al.
AGING CELL (2019)
Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model
Hui Mai et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2019)
The dawn of pirna research in various neuronal disorders
Keiko Tsuji Wakisaka et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2019)
M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124
Yaying Song et al.
THERANOSTICS (2019)
Microglia in Alzheimer's disease
David V. Hansen et al.
JOURNAL OF CELL BIOLOGY (2018)
MicroRNAs: Roles in Regulating Neuroinflammation
Andrew D. Gaudet et al.
NEUROSCIENTIST (2018)
The cost of Alzheimer's disease in China and re-estimation of costs worldwide
Jianping Jia et al.
ALZHEIMERS & DEMENTIA (2018)
Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKβ/NF-kB signaling pathway
Heng-Jun Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)
miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain
Tingfei Yan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway
Fenghui Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination
Chenfan Duan et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Secretome from SH-SY5Y APP(Swe) cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling
Adelaide Fernandes et al.
BIOCHIMIE (2018)
MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation
Jingfang Lv et al.
BRAIN RESEARCH (2018)
Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis
Fei Xing et al.
CANCER RESEARCH (2018)
Regulatory effects of the long non-coding RNA RP11-543N12.1 and microRNA-324-3p axis on the neuronal apoptosis induced by the inflammatory reactions of microglia
Miao Cai et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)
LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy
Chun-Lei Han et al.
JOURNAL OF NEUROINFLAMMATION (2018)
miR-302/367-induced neurons reduce behavioral impairment in an experimental model of Alzheimer's disease
Maryam Ghasemi-Kasman et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2018)
Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration
Rituraj Niranjan
NEUROCHEMISTRY INTERNATIONAL (2018)
Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia
Hong Wei et al.
NEUROSCIENCE (2018)
ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity (vol 12, e0177814, 2017)
Diego Mastroeni et al.
PLOS ONE (2018)
The Role of Microglia in the Spread of Tau: Relevance for Tauopathies
Juan R. Perea et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling
Li-Qing Wang et al.
SCIENTIFIC REPORTS (2018)
Noncoding RNAs in Alzheimer's disease
M. Laura Idda et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2018)
Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies
Neelima Gupta et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
Microglia in neurodegeneration
Suzanne Hickman et al.
NATURE NEUROSCIENCE (2018)
A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS-and MPTP-induced neuroinflammation
Yongyi Ye et al.
CELL DEATH & DISEASE (2018)
Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status
Menglian Lv et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2018)
Inhibition of miR-128 Abates A beta-Mediated Cytotoxicity by Targeting PPAR-gamma via NF-kappa B Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells
Lijiao Geng et al.
YONSEI MEDICAL JOURNAL (2018)
Non-coding RNA networks in cancer
Eleni Anastasiadou et al.
NATURE REVIEWS CANCER (2018)
Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation
Ana S. Falcao et al.
ACS CHEMICAL NEUROSCIENCE (2017)
MicroRNA-27a Negatively Modulates the Inflammatory Response in Lipopolysaccharide-Stimulated Microglia by Targeting TLR4 and IRAK4
Yan-ni Lv et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)
Non-coding RNAs as drug targets
Masayuki Matsui et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway
Yue Sun et al.
EXPERIMENTAL CELL RESEARCH (2017)
Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer's Disease in APP/PS1 Transgenic Mouse
Honghai Hong et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Targeting noncoding RNAs in disease
Brian D. Adams et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
CircRNA: functions and properties of a novel potential biomarker for cancer
Shujuan Meng et al.
MOLECULAR CANCER (2017)
LONG NON-CODING RNA SNHG14 PROMOTES MICROGLIA ACTIVATION BY REGULATING MIR-145-5P/PLA2G4A IN CEREBRAL INFARCTION
Xu Qi et al.
NEUROSCIENCE (2017)
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling
Sam Strickson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
Kotb Abdelmohsen et al.
RNA BIOLOGY (2017)
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants
Katie J. Ryan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization
Jue Wang et al.
STROKE (2017)
MicroRNA-93 inhibits inflammatory responses and cell apoptosis after cerebral ischemia reperfusion by targeting interleukin-1 receptor-associated kinase 4
Feng Tian et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)
Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation
Claudia Caldeira et al.
FRONTIERS IN AGING NEUROSCIENCE (2017)
Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38
Zhaoyun Yang et al.
MEDICAL SCIENCE MONITOR (2017)
miR-145-5p/Nurr1/TNF-α Signaling-Induced Microglia Activation Regulates Neuron Injury of Acute Cerebral Ischemic/Reperfusion in Rats
Xuemei Xie et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology
Nicole M. Maphis et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination
Dingya Sun et al.
EMBO REPORTS (2017)
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease
Peter Parbo et al.
BRAIN (2017)
LncRNA Gm4419 contributes to OGD/R injury of cerebral microglial cells via IκB phosphorylation and NF-κB activation
Yuanchao Wen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease
Claudia Balducci et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
Revealing protein-lncRNA interaction
Fabrizio Ferre et al.
BRIEFINGS IN BIOINFORMATICS (2016)
Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders
Vera Paschon et al.
MOLECULAR NEUROBIOLOGY (2016)
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Yu Tang et al.
MOLECULAR NEUROBIOLOGY (2016)
Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders
Mithilesh Kumar Jha et al.
BIOCHEMICAL PHARMACOLOGY (2016)
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
Somayyeh Hamzei Taj et al.
BIOMATERIALS (2016)
Downregulated serum miR-223 servers as biomarker in Alzheimer's disease
Li-Hua Jia et al.
CELL BIOCHEMISTRY AND FUNCTION (2016)
MicroRNA-125b regulates microglia activation and motor neuron death in ALS
C. Parisi et al.
CELL DEATH AND DIFFERENTIATION (2016)
Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Ana L. Cardoso et al.
CURRENT OPINION IN PHARMACOLOGY (2016)
Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation
Ming-Lei Guo et al.
EPIGENETICS (2016)
Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells
Heng-Jun Zhou et al.
EXPERIMENTAL CELL RESEARCH (2016)
Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review
Sayantan Ghosh et al.
GENE (2016)
LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling
Guoku Hu et al.
JOURNAL OF IMMUNOLOGY (2016)
Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice
Huimin Zhou et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2016)
Regulatory mechanisms of microRNA expression
Lyudmila F. Gulyaeva et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2016)
Upregulation of microRNA-206 enhances lipopolysaccharide-induced inflammation and release of amyloid-β by targeting insulin-like growth factor 1 in microglia
Hongxia Xing et al.
MOLECULAR MEDICINE REPORTS (2016)
A polarizing question: do M1 and M2 microglia exist?
Richard M. Ransohoff
NATURE NEUROSCIENCE (2016)
Regulation of proapoptotic proteins Bak1 and p53 by miR-125b in an experimental model of Alzheimer's disease: Protective role of 17β-estradiol
F. Micheli et al.
NEUROSCIENCE LETTERS (2016)
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
William W. Du et al.
NUCLEIC ACIDS RESEARCH (2016)
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline
Amy K. Y. Fu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Microglia: Architects of the Developing Nervous System
Jeffrey L. Frost et al.
TRENDS IN CELL BIOLOGY (2016)
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
Nicole Maphis et al.
BRAIN (2015)
Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease
Zhen Fan et al.
BRAIN (2015)
Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia
Lihong Li et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia
Asit Kumar et al.
JOURNAL OF NEUROCHEMISTRY (2015)
MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4
Li Zhang et al.
JOURNAL OF NEUROCHEMISTRY (2015)
MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage
Bangqing Yuan et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Agnieszka Rybak-Wolf et al.
MOLECULAR CELL (2015)
miR-203 protects microglia mediated brain injury by regulating inflammatory responses via feedback to MyD88 in ischemia
Zhao Yang et al.
MOLECULAR IMMUNOLOGY (2015)
NON-CODING RNA Towards a molecular understanding of microRNA-mediated gene silencing
Stefanie Jonas et al.
NATURE REVIEWS GENETICS (2015)
Discovery of protein-lncRNA interactions by integrating large-scale CLIP-Seq and RNA-Seq datasets
Jun-Hao Li et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2015)
Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
Joana R. Guedes et al.
HUMAN MOLECULAR GENETICS (2014)
Circulating miR-125b as a biomarker of Alzheimer's disease
Lin Tan et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2014)
Regulation of Neurotropic Signaling by the Inducible, NF-kB-Sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells
Yuhai Zhao et al.
MOLECULAR NEUROBIOLOGY (2014)
Regulation of microRNA biogenesis
Minju Ha et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
MiR-9 promotes microglial activation by targeting MCPIP1
Honghong Yao et al.
NATURE COMMUNICATIONS (2014)
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease
Brian S. Clark et al.
FRONTIERS IN GENETICS (2014)
Microglial pathology
Wolfgang J. Streit et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Regulation of STAT3 by miR-106a is linked to cognitive impairment in ovariectomized mice
Min Zhang et al.
BRAIN RESEARCH (2013)
Involvement of MicroRNA in Microglia-Mediated Immune Response
J. Guedes et al.
CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013)
MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS
Eugene D. Ponomarev et al.
GLIA (2013)
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes
Emmette R. Hutchison et al.
GLIA (2013)
Presenilin 2 influences miR146 level and activity in microglia
Suman Jayadev et al.
JOURNAL OF NEUROCHEMISTRY (2013)
miR-26a promotes neurite outgrowth by repressing PTEN expression
Baoguo Li et al.
MOLECULAR MEDICINE REPORTS (2013)
Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
Carlo Sala Frigerio et al.
NEUROLOGY (2013)
Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia
Robert W. Freilich et al.
PLOS ONE (2013)
MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation
Haiping Zhao et al.
STROKE (2013)
Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells
L. Yang et al.
CELL DEATH & DISEASE (2013)
Plasma microRNA biomarkers for detection of mild cognitive impairment
Kira S. Sheinerman et al.
AGING-US (2012)
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Norbert Zilka et al.
JOURNAL OF NEUROINFLAMMATION (2012)
HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia
Ritu Mishra et al.
JOURNAL OF NEUROINFLAMMATION (2012)
MicroRNA profiling: approaches and considerations
Colin C. Pritchard et al.
NATURE REVIEWS GENETICS (2012)
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
Moran N. Cabili et al.
GENES & DEVELOPMENT (2011)
A trio of microRNAs that control Toll-like receptor signalling
Susan R. Quinn et al.
INTERNATIONAL IMMUNOLOGY (2011)
Kruppel-like factor 4 regulates macrophage polarization
Xudong Liao et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Mechanisms Underlying Inflammation in Neurodegeneration
Christopher K. Glass et al.
CELL (2010)
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Kiran Bhaskar et al.
NEURON (2010)
Onco-miR-155 targets SHIP1 to promote TNFα-dependent growth of B cell lymphomas
Irene M. Pedersen et al.
EMBO MOLECULAR MEDICINE (2009)
Role of miRNA-146a in the regulation of the innate immune response and cancer
Andrew E. Williams et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells
Walter J. Lukiw et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
MicroRNA-155 is induced during the macrophage inflammatory response
Ryan M. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Michelle L. Block et al.
NATURE REVIEWS NEUROSCIENCE (2007)