Incident COVID-19 and Hospitalizations by Variant Era Among Vaccinated Solid Organ Transplant Recipients

Article Multidisciplinary Sciences

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Rigel Suzuki et al.

Summary: The Omicron variant of SARS-CoV-2 has spread rapidly in several countries and has shown lower fusogenicity and attenuated pathogenicity compared to the Delta variant.

NATURE (2022)

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Article Immunology

mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients

Jennie H. Kwon et al.

Summary: The effectiveness of COVID-19 mRNA vaccines in preventing COVID-19 hospitalization is lower for solid organ transplant (SOT) recipients compared to immunocompetent individuals and those with other immunocompromising conditions. Among SOT recipients, receiving 3 doses of an mRNA vaccine provides significantly greater protection than receiving 2 doses.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Surgery

Outcome of COVID-19 in Kidney Transplant Recipients Through the SARS-CoV-2 Variants Eras: Role of Anti-SARS-CoV-2 Monoclonal Antibodies

Matthaios Papadimitriou-Olivgeris et al.

Summary: Kidney transplant recipients are at higher risk for COVID-19 complications. This study examines the epidemiology and outcome of PCR-documented SARS-CoV-2 infection in KTR patients from March 2020 to May 2022. Early administration of monoclonal antibodies and a lower Charlson Comorbidity Index are associated with better outcomes.

TRANSPLANT INTERNATIONAL (2022)

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Article Immunology

Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study

Olivia S. Kates et al.

Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Immunology