☆ 4.7 Article

Low-intensity pulsed ultrasound alleviates doxorubicin-induced cardiotoxicity via inhibition of S100a8/a9-mediated cardiac recruitment of neutrophils

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Article Immunology

Hydrogen inhalation enhances autophagy via the AMPK/mTOR pathway, thereby attenuating doxorubicin-induced cardiac injury

Tianjiao Ma et al.

Summary: The purpose of this study was to investigate the protective effect of hydrogen inhalation on chronic myocardial injury induced by doxorubicin and its effect and mechanism on autophagy. The results confirmed that hydrogen inhalation can improve cardiac function decline and pathological structural abnormalities induced by doxorubicin, activate autophagy through the AMPK/mTOR pathway, and protect against myocardial injury.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Article Toxicology

Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1a-mediated mitochondrial biogenesis

Meicong Chen

Summary: This study aimed to investigate the functions and possible mechanisms of empagliflozin in doxorubicin (Dox)-induced cardiotoxicity. The results showed that continuous intraperitoneal injection of Dox impaired cardiac function and caused pathological damage in myocardial tissues. Empagliflozin treatment improved myocardial histopathological damage, cardiac function, excessive oxidative stress, and dysregulation of energy metabolism. Moreover, empagliflozin activated the AMPK/SIRT-1/PGC-1 alpha signaling pathway in Dox-induced cardiotoxicity. Overall, empagliflozin has cardioprotective effects and may exert these effects through the activation of the AMPK/SIRT-1/PGC-1 alpha pathway.

TOXICOLOGY RESEARCH (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts

Liqing Weng et al.

Summary: Low-intensity pulsed ultrasound (LIPUS) can inhibit diabetic heart fibrosis by inhibiting ACE-mediated oxidative stress and NLRP3 inflammasome activation.

CARDIOVASCULAR DRUGS AND THERAPY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement

Joerg Herrmann et al.

Summary: The discipline of Cardio-Oncology focuses on the cardiovascular care of cancer patients and the management of cardiovascular complications of cancer therapies. This document provides consensus definitions for common cardiovascular toxicities and aims to improve communication and outcomes in clinical practice and research.

EUROPEAN HEART JOURNAL (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Anthracyclines: biosynthesis, engineering and clinical applications

Mandy B. Hulst et al.

Summary: Doxorubicin, widely used in cancer treatment but limited by its severe side-effects, may be surpassed by new anthracycline-based drugs that focus on histone eviction activity to avoid cardiac toxicity. Recent advancements in biosynthesis and discovery of new congeners from rare Actinobacteria have laid the foundation for the development of novel anthracyclines.

NATURAL PRODUCT REPORTS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Resolvin D1 Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Inflammation, Oxidative and Endoplasmic Reticulum Stress

Menglong Wang et al.

Summary: This study demonstrates that RvD1 attenuates Dox-induced cardiac injury through improving cardiac function, reducing apoptosis and oxidative stress, and inhibiting inflammation and endoplasmic reticulum stress.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity

Yanqiu Lai et al.

Summary: Transcutaneous vagal nerve stimulation (tVNS) plays a cardio-protective role in preventing doxorubicin (DOX)-induced cardiotoxicity by rebalancing autonomic tone and reducing cardiac damage. tVNS also regulates immune system genes involved in the underlying mechanisms.

CARDIOVASCULAR RESEARCH (2022)

Add to Collection

Review Toxicology

Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation

Nonhlakanipho F. Sangweni et al.

Summary: A breakthrough in oncology research was the discovery of doxorubicin (Dox), a chemotherapy drug with a higher therapeutic index. However, its clinical significance is tainted by its adverse side effects, particularly cardiotoxicity, due to its lack of specificity in distinguishing cancer cells from healthy cells. Dox induces cytotoxicity by stimulating the production of pro-oxidants and inhibiting antioxidant enzymatic activity in both cancer and cardiac cells. The low antioxidant capacity of cardiac muscle makes it susceptible to oxidative damage and triggers cell death pathways.

ARCHIVES OF TOXICOLOGY (2022)

Add to Collection

Review Cell & Tissue Engineering

Advances in the application of low-intensity pulsed ultrasound to mesenchymal stem cells

Peng Xia et al.

Summary: This article reviews the progress in research on the use of LIPUS with various MSCs and comprehensively discusses the progress in the use of LIPUS for promoting the proliferation, differentiation, and migration of MSCs, as well as its future prospects.

STEM CELL RESEARCH & THERAPY (2022)

Add to Collection

Review Oncology

Low-Intensity Focused Ultrasound Technique in Glioblastoma Multiforme Treatment

Rajneesh Mungur et al.

Summary: The use of LIFU+MBs in drug delivery for glioblastoma has shown to be a safe and effective method, with improved drug uptake and tumor control without causing harm to brain structures.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Nanoscience & Nanotechnology

Detection of Anticancer Drug-Induced Cardiotoxicity Using VCAM1-Targeted Nanoprobes

Humayra Afrin et al.

Summary: Chemotherapy-induced cardiac toxicity is a common effect that is difficult to monitor and detect at an early stage. This study developed a fluorescent nanoprobe to image the toxicity in cardiac tissue induced by an anticancer drug. The nanoprobe showed selective binding to inflamed cells, indicating its potential for early detection of cardiac toxicity and damage.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2-Mediated Suppression of NLRP3 Inflammasome Activation

Xuan Sun et al.

Summary: This study suggests that colchicine may have therapeutic potential for dilated cardiomyopathy and other nonischemic heart failure associated with the inflammatory response.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Add to Collection

Review Oncology

Low Intensity Ultrasound as an Antidote to Taxane/ Paclitaxel-induced Cytotoxicity

Celina Amaya et al.

Summary: Taxane drugs, such as Taxol and Taxotere, are commonly used in chemotherapy for solid tumors. However, their major side effects, including neuropathy and alopecia, limit their efficacy. A recent laboratory finding suggests that low intensity ultrasound may be an effective solution to counter taxane cytotoxicity.

JOURNAL OF CANCER (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction

Yuto Monma et al.

Summary: The LIPUS therapy has shown to effectively ameliorate cardiac diastolic dysfunction in mice, improving relaxation properties at the tissue level and potentially offering treatment benefits for patients with heart failure with preserved left ventricular ejection fraction (HFpEF).

CARDIOVASCULAR RESEARCH (2021)

Add to Collection

Article Acoustics

Longitudinal effects of low-intensity pulsed ultrasound on osteoporosis and osteoporotic bone defect in ovariectomized rats

Shuxin Sun et al.

Summary: The study used two intensity levels of LIPUS, 30 mW/cm² and 150 mW/cm², to treat osteoporosis and osteoporotic bone defect in OVX rats. Results showed that 150 mW/cm² LIPUS led to faster healing of the bone defect compared to 30 mW/cm² after 3 weeks, but did not further enhance healing after 6 weeks. Additionally, 150 mW/cm² LIPUS had more advantages in improving bone density, microstructure, and biomechanics for osteoporosis compared to 30 mW/cm² after 6 weeks.

ULTRASONICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway

Kun Zhao et al.

Summary: LIPUS can ameliorate AngII-induced cardiac fibrosis by reducing the release of inflammatory cytokines, improving left ventricular remodeling in vivo and cardiac fibrosis in vitro, but its protective effects on cardiac hypertrophy are limited.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2021)

Add to Collection

Article Cell Biology

Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice

Jianwei Zhang et al.

Summary: This study found that DOX increased the expression of IL-16 in cardiac macrophages. The anti-IL-16 nAb significantly reduced serum LDH, myocardial CK-MB, and cardiac cTnT levels in DOX-induced mice, while also improving cardiac function. Additionally, the anti-IL-16 nAb reduced M1 macrophage-related markers and cytokine expression, and protected against cardiomyocyte apoptosis in DOX-induced mice.

MEDIATORS OF INFLAMMATION (2021)

Add to Collection

Article Orthopedics

The use of low intensity pulsed ultrasound in the foot and ankle

Mustafa S. Rashid et al.

Summary: Low intensity pulsed ultrasound (LIPUS) therapy has shown clinical effectiveness in achieving union in various fracture situations, with an overall rate of 95% in published studies. Studies suggest lower healing rates, around 67%, when used for hindfoot fusion nonunion. More research is needed to demonstrate the clinical and cost effectiveness of LIPUS therapy in foot and ankle surgery.

EFORT OPEN REVIEWS (2021)

Add to Collection

Review Medicine, Research & Experimental

Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

Pushkar Singh Rawat et al.

Summary: Doxorubicin, a commonly used anti-cancer drug, exerts its activity through DNA intercalation and inhibition of topoisomerase II enzyme. However, its use is limited by its dose-dependent cardiotoxicity, which is believed to involve oxidative stress, apoptosis, and various other mechanisms. Pharmacological strategies have been explored to mitigate Doxorubicin-induced cardiotoxicity.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction

Gopalkrishna Sreejit et al.

CIRCULATION (2020)

Add to Collection

Review Clinical Neurology

Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives

Kevin Beccaria et al.

NEUROSURGICAL FOCUS (2020)

Add to Collection

Article Acoustics

THERAPEUTIC EFFECTS OF LOW-INTENSITY PULSED ULTRASOUND ON OSTEOPOROSIS IN OVARIECTOMIZED RATS: INTENSITY-DEPENDENT STUDY

Shuxin Sun et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

S100A9 Links Inflammation and Repair in Myocardial Infarction

Goran Marinkovic et al.

CIRCULATION RESEARCH (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle

Tima Dehghani et al.

OPEN BIOLOGY (2020)

Add to Collection

Letter Hematology

NETosis Is Required for S100A8/A9-Induced Granulopoiesis After Myocardial Infarction

Prabhakara R. Nagareddy et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction

Goran Marinkovic et al.

EUROPEAN HEART JOURNAL (2019)

Add to Collection

Article Medicine, General & Internal

Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases

Helen Strongman et al.

LANCET (2019)

Add to Collection

Article Cell Biology

Low-intensity pulsed ultrasound attenuates cardiac inflammation of CVB3-induced viral myocarditis via regulation of caveolin-1 and MAPK pathways

Cheng Zheng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Add to Collection

Article Hematology

Low-Intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Mouse Model of Acute Myocardial Infarction

Tomohiko Shindo et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Add to Collection

Article Cell Biology

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

Raffaella Mastrocola et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Add to Collection

Article Pharmacology & Pharmacy

Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity

Michela Pecoraro et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Add to Collection

Article Pharmacology & Pharmacy

Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice

G. Ronald Jenkins et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Add to Collection

Article Physiology

S100A8 and S100A9 Are Associated with Doxorubicin-Induced Cardiotoxicity in the Heart of Diabetic Mice

Xiao M. Pei et al.

FRONTIERS IN PHYSIOLOGY (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction

Hendrik B. Sager et al.

CIRCULATION (2015)

Add to Collection

Article Cardiac & Cardiovascular Systems

Sexual Dimorphism of Doxorubicin-Mediated Cardiotoxicity Potential Role of Energy Metabolism Remodeling

Maryline Moulin et al.

CIRCULATION-HEART FAILURE (2015)

Add to Collection

Article Peripheral Vascular Disease

S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury

Yina Wu et al.

HYPERTENSION (2014)

Add to Collection

Review Acoustics

Stimulation of bone repair with ultrasound: A review of the possible mechanic effects

Frederic Padilla et al.

ULTRASONICS (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

H. Christian Volz et al.

BASIC RESEARCH IN CARDIOLOGY (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Sui Zhang et al.

NATURE MEDICINE (2012)

Add to Collection

Review Cardiac & Cardiovascular Systems

Doxorubicin Cardiomyopathy

Kanu Chatterjee et al.

CARDIOLOGY (2010)

Add to Collection

Article Pharmacology & Pharmacy

Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity

Jinzhou Zhu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

Add to Collection

© Peeref 2019-2024. All rights reserved.