☆ 4.8 Article

Small extrachromosomal circular DNAs as biomarkers for multi-cancer diagnosis and monitoring

CLINICAL AND TRANSLATIONAL MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Article Biochemical Research Methods

Purification, full-length sequencing and genomic origin mapping of eccDNA

Yuangao Wang et al.

Summary: A new three-step eccDNA purification (3SEP) procedure is proposed to efficiently purify eccDNA with high purity. In addition, a full-length eccDNA sequencing technique is developed, along with an eccDNA caller software, for accurate identification and mapping of eccDNA. These methods will facilitate the study of eccDNA and have potential diagnostic and clinical applications.

NATURE PROTOCOLS (2023)

Add to Collection

Article Oncology

Long non-coding RNA CCL14-AS suppresses invasiveness and lymph node metastasis of colorectal cancer cells by regulating MEP1A

Mingzhou Li et al.

Summary: By analyzing the TCGA dataset, we identified a novel lncRNA called CCL14-AS, which is enriched in the cytoplasm and negatively correlated with lymph node metastasis and unfavorable prognosis of colorectal cancer (CRC). Functional experiments and mouse models confirmed the inhibitory role of CCL14-AS in CRC. Our findings suggest that the CCL14-AS/MEP1A axis serves as a critical regulator in CRC progression and may be a potential biomarker and therapeutic target in advanced CRC.

CANCER CELL INTERNATIONAL (2023)

Add to Collection

Review Genetics & Heredity

Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

Julie B. Noer et al.

Summary: Extrachromosomal circular DNA (eccDNA) plays important roles in cancer pathogenesis, tumor heterogeneity evolution, and therapeutic resistance. This review provides an overview of the different names, formation mechanisms, and research methods of eccDNA, as well as explores its potential clinical value.

TRENDS IN GENETICS (2022)

Add to Collection

Article Medicine, General & Internal

Identification and Characterization of Extrachromosomal Circular DNA in Plasma of Lung Adenocarcinoma Patients

Xiaoqiong Wu et al.

Summary: The study identified cancer-specific eccDNA in the plasma of lung adenocarcinoma patients, potentially serving as promising biomarkers for early diagnosis. A comparison with healthy individuals and healthy gravidas revealed four eccDNA uniquely expressed in lung adenocarcinoma patients, which could be potential markers for early detection.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Add to Collection

Article Medical Laboratory Technology

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Sarah T. K. Sin et al.

Summary: The research found that fetal eccDNA in plasma is relatively hypomethylated compared to maternal eccDNA. The methylation densities of eccDNA are positively correlated with their sizes. Fetal eccDNA is rapidly cleared from maternal blood after delivery, similar to fetal linear DNA.

CLINICAL CHEMISTRY (2021)

Add to Collection

Article Multidisciplinary Sciences

eccDNAs are apoptotic products with high innate immunostimulatory activity

Yuangao Wang et al.

Summary: By developing a new eccDNA purification and profiling method, the study revealed close-to-random genomic origination, mechanism of biogenesis and function of eccDNAs.

NATURE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage

Teressa Paulsen et al.

Summary: This study suggests that microDNA levels are influenced by resection after double-strand DNA break (DSB) and repair by Microhomology Mediated End Joining (MMEJ). The accumulation of microDNA occurs during DNA repair pathways following endogenous or induced DNA breaks.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Review Medicine, Research & Experimental

Extrachromosomal circular DNA: a new potential role in cancer progression

Tianyi Wang et al.

Summary: eccDNA, a circular DNA molecule existing widely in nature and independent of conventional chromosomes, is a product of genomic instability with important biological functions, potentially involved in the occurrence of various diseases, including cancer.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer

Xiaoxuan Ling et al.

Summary: eccDNA is a type of circular DNA that is independent of chromosomes but plays important roles in monitoring, early diagnosis, treatment, and prediction of cancer. They are commonly found in both normal and cancer cells, functioning through various mechanisms in stress response, aging, carcinogenesis, and drug resistance during cancer treatment.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Deciphering extrachromosomal circular DNA in Arabidopsis

Keyi Wang et al.

Summary: This study provides insights into the nature and origin of eccDNA in plants, showing that eccDNA is not only related to transposon activity, but also contains tRNA genes, suggesting a potential link to tRNA abundance and protein synthesis control under stress conditions.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Add to Collection

Article Biology

Phospholipase D as a key modulator of cancer progression

Yuanfa Yao et al.

BIOLOGICAL REVIEWS (2020)

Add to Collection

Article Multidisciplinary Sciences

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Sarah T. K. Sin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Multidisciplinary Sciences

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Pankaj Kumar et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Multidisciplinary Sciences

Pervasive chromosomal instability and karyotype order in tumour evolution

Thomas B. K. Watkins et al.

NATURE (2020)

Add to Collection

Article Clinical Neurology

Structure and evolution of double minutes in diagnosis and relapse brain tumors

Ke Xu et al.

ACTA NEUROPATHOLOGICA (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters

Teressa Paulsen et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Review Oncology

Life and death of circulating cell-free DNA

Anatoli Kustanovich et al.

CANCER BIOLOGY & THERAPY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

Andrew R. Morton et al.

CELL (2019)

Add to Collection

Article Gastroenterology & Hepatology

Nomogram to predict prolonged postoperative ileus after gastrectomy in gastric cancer

Wen-Quan Liang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Add to Collection

Article Medicine, General & Internal

Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma

Eun Kyo Joung et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Viraj Deshpande et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Review Genetics & Heredity

Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells

Teressa Paulsen et al.

TRENDS IN GENETICS (2018)

Add to Collection

Article Multidisciplinary Sciences

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Henrik Devitt Moller et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Review Cell Biology

A lifetime of stress: ATF6 in development and homeostasis

Robert F. Hillary et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Cooperative genomic alteration network reveals molecular classification across 12 major cancer types

Hongyi Zhang et al.

NUCLEIC ACIDS RESEARCH (2017)

Add to Collection

Article Oncology

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer

Filippo Pietrantonio et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Add to Collection

Article Oncology

Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation

Pankaj Kumar et al.

MOLECULAR CANCER RESEARCH (2017)

Add to Collection

Article Oncology

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer

Filippo Pietrantonio et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Add to Collection

Article Multidisciplinary Sciences

Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines

Pamela Mehanna et al.

PLOS ONE (2017)

Add to Collection

Review Oncology

Transposable elements in cancer

Kathleen H. Burns

NATURE REVIEWS CANCER (2017)

Add to Collection

Article Oncology

Metalloproteases meprin-α (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Xiao Wang et al.

BMC CANCER (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

Phillippa C. Taberlay et al.

GENOME RESEARCH (2016)

Add to Collection

Article Gastroenterology & Hepatology

MEP1A Contributes to Tumor Progression and Predicts Poor Clinical Outcome in Human Hepatocellular Carcinoma

Han-Yue OuYang et al.

HEPATOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Extrachromosomal circular DNA is common in yeast

Henrik D. Moller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Add to Collection

Article Multidisciplinary Sciences

LINE-1 Hypomethylation in Blood and Tissue Samples as an Epigenetic Marker for Cancer Risk: A Systematic Review and Meta-Analysis

Martina Barchitta et al.

PLOS ONE (2014)

Add to Collection

Review Genetics & Heredity

Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration

Doris Bachtrog

NATURE REVIEWS GENETICS (2013)

Add to Collection

Article Oncology

ALU and LINE-1 hypomethylations in multistep gastric carcinogenesis and their prognostic implications

Jeong Mo Bae et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Add to Collection

Article Multidisciplinary Sciences

Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues

Yoshiyuki Shibata et al.

SCIENCE (2012)

Add to Collection

Article Multidisciplinary Sciences

Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus

David Gresham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection

Article Biochemical Research Methods

Control of pH during plasmid preparation by alkaline lysis of Escherichia coli

Cheri Cloninger et al.

ANALYTICAL BIOCHEMISTRY (2008)

Add to Collection

Article Neurosciences

Isolation of neuronal chromatin from brain tissue

Yan Jiang et al.

BMC NEUROSCIENCE (2008)

Add to Collection

Article Oncology

Restored expression of the MY018B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice

Nobutaka Edakuni et al.

ONCOLOGY RESEARCH (2006)

Add to Collection

Article Mathematical & Computational Biology

Estimation of the Youden index and its associated cutoff point

R Fluss et al.

BIOMETRICAL JOURNAL (2005)

Add to Collection

Article Oncology

Reduced expression of MY018B, a candidate tumor-suppressor gene on chromosome arm 22% in ovarian cancer

N Yanaihara et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

Add to Collection

Article Multidisciplinary Sciences

MY018B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer

M Nishioka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.