Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Article Multidisciplinary Sciences

Chiral polypeptide nanoparticles as nanoadjuvants of nanovaccines for efficient cancer prevention and therapy

Yuanzhen Su et al.

Summary: Two types of chiral polypeptide nanoparticles were used as nanoadjuvants for cancer prevention and therapy, exhibiting excellent performance in inducing immune response and anti-tumor effects.

SCIENCE BULLETIN (2023)

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Article Engineering, Biomedical

Engineered bacteria combined with doxorubicin nanoparticles suppress angiogenesis and metastasis in murine melanoma models

Meiyang Yang et al.

Summary: The development of an engineered bacteria delivery system that can distribute throughout the entire tumor and suppress metastasis is of great significance in cancer treatment improvement.

ACTA BIOMATERIALIA (2023)

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Article Chemistry, Multidisciplinary

Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy

Xupeng Yang et al.

Summary: This study determines that reprogramming the metabolism of immature dendritic cells (iDCs) and tumor-associated macrophages (TAMs) can enhance the ratio of mature dendritic cells (mDCs) and proinflammatory macrophages, thus improving the immune response against triple-negative breast cancer. The findings provide a candidate method for monitoring treatment and augmenting antitumor chemoimmunotherapy by suppressing tumor cell autophagy and reprogramming immunocyte metabolism.

ACS NANO (2022)

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Article Engineering, Biomedical

Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy

Wenbo Han et al.

Summary: This study demonstrates the enhanced antitumor efficacy of DHA through co-delivery with a cholesterol derivative and an iron complex in nanoparticles. The combination treatment also improves tumor immunogenicity, making non-immunogenic colorectal tumors more susceptible to immunotherapy.

BIOMATERIALS (2022)

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Editorial Material Oncology

Antihistamines for cancer immunotherapy: More than just treating allergies

Song Chen et al.

Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.

CANCER CELL (2022)

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Article Oncology

The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1

Hongzhong Li et al.

Summary: Antihistamines can improve survival in cancer patients by reversing T cell dysfunction through modulation of histamine receptor H1 (HRH1), thereby enhancing immunotherapy responses.

CANCER CELL (2022)

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Review Oncology

First-Line Immunotherapy for Non-Small-Cell Lung Cancer

Martin Reck et al.

Summary: The past decade has seen significant progress in the treatment of metastatic non-small-cell lung cancer, with the development of specific antibodies leading to improved survival for many patients. Currently, nearly all mNSCLC patients receive PD-1 or PD-L1 therapy in the first-line setting, except those with targetable oncogenes.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Medicine, General & Internal

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

Hussein A. Tawbi et al.

Summary: LAG-3 and PD-1 are two distinct inhibitory immune checkpoints that contribute to T-cell exhaustion. The combination of relatlimab and nivolumab has been shown to be safe and effective in previously treated melanoma patients, and this study aimed to evaluate its safety and activity in previously untreated melanoma patients. The results demonstrated that the combination therapy provided a greater benefit in terms of progression-free survival compared to nivolumab alone, without any new safety signals.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Oncology

Nanoparticle-based drug delivery systems in cancer: A focus on inflammatory pathways

Amir R. Afshari et al.

Summary: Inflammation plays a critical role in cancer development, while nanoparticles have potential value in cancer treatment.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Medicine, Research & Experimental

Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer

Fang Yuan et al.

Summary: Pancreatic cancer cells with high levels of macropinocytosis can be targeted using macropinocytic dextran as a delivery carrier. Conjugating triptolide with 70 kDa dextran enhances the therapeutic effects on KRAS mutant cells and preserves immune factors, reducing the impact on T cells.

THERANOSTICS (2022)

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Article Engineering, Biomedical

Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors

Shindu C. Thomas et al.

Summary: Desmoplastic solid tumors are characterized by the rapid accumulation of extracellular matrix macromolecules, but a hypervesiculating E. coli Nissle based tumor-targeting system has been developed to disrupt the tumor stroma using fusion peptides. By combining this system with immune checkpoint antibodies and tyrosine kinase inhibitors, improved immunotherapy outcomes and enhanced efficacy of biological signaling inhibitors can be achieved. The engineered bacterial vector shows biocompatibility and has the potential to be a reliable live biotherapeutic candidate.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Development of a Localized Drug Delivery System with a Step-by-Step Cell Internalization Capacity for Cancer Immunotherapy

Xilin Li et al.

Summary: In this study, a localized drug delivery system based on a hierarchical-structured fiber device was developed to precisely reprogram tumor-associated macrophages (TAMs) and combine them with immunogenic cell death (ICD), aiming to enhance the antitumor immunotherapeutic effect.

ACS NANO (2022)

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Article Engineering, Biomedical

Tumor microcalcification-me diate d relay drug delivery for photodynamic immunotherapy of breast cancer

Hui Jian et al.

Summary: Spatiotemporal targeting of tumor-associated macrophages (TAMs) and tumor cells is an emerging strategy for tumor therapy. In this study, researchers developed a nanosystem that utilizes tumor microcalcifications to deliver drugs for breast cancer therapy. The nanosystem showed effective photodynamic and immunoregulatory performance in both in vitro and in vivo experiments.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

TRAIL-modifie d, doxorubicin-emb e dde d periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy

Xinyao Feng et al.

Summary: This study successfully achieved enhanced degradation and controllable light irradiation of nanoparticles by introducing calcium oxalate and photon engineering. This method can promote drug release and has potential applications in tumor therapy.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

A Tumor Microenvironments-Adapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecularly Targeted Inhibition and Immunoactivation

Zhongmin Li et al.

Summary: In this study, a composite material that adapts to the tumor microenvironment by sequentially releasing drugs was developed. The material consists of a thermosensitive hydrogel and a reactive oxygen species-responsive nanogel. The composite effectively inhibits tumor growth and metastasis in mouse models by increasing the infiltration of CD8(+) T cells, reducing the recruitment of tumor-associated macrophages and myeloid-derived suppressor cells, and promoting the polarization of macrophages from M2 to M1 type.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Recruitment of dendritic cells using 'find-me' signaling microparticles for personalized cancer immunotherapy

Jae Ah Lee et al.

Summary: Therapeutic cancer vaccines have the potential to activate highly specific cytotoxic T cells, making them an attractive option for personalized cancer immunotherapy. However, their low immunogenicity has limited their use in clinical settings. To overcome this limitation, researchers have developed 'find-me' signaling polymeric microparticles (F-PMs) that efficiently recruit dendritic cells (DCs) and facilitate antigen presentation. When injected into tumor-bearing mice, F-PMs significantly increase mature DCs in the lymph nodes, resulting in effective tumor inhibition. Moreover, co-administration of F-PMs and an immune checkpoint inhibitor leads to a higher enrichment of CD8+ cytotoxic T cells in the tumor microenvironment. This study demonstrates the potential of F-PMs as a promising therapeutic option for cancer treatment.

BIOMATERIALS (2022)

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Article Oncology

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Yared Hailemichael et al.

Summary: Immune checkpoint blockade therapy can cause immune-related adverse events. IL-6 expression is higher in colitis and Th17 cells are more prevalent in immune-related enterocolitis. Anti-CTLA-4 induces stronger Th17 memory in colitis than anti-PD-1. In mouse models, IL-6 blockade enhances tumor control and increases CD4(+)/CD8(+) effector T cell density, while reducing Th17, macrophages, and myeloid cells. Combined IL-6 blockade and ICB enhances tumor rejection and mitigates EAE symptoms. IL-6 blockade with ICB can decouple autoimmunity from antitumor immunity.

CANCER CELL (2022)

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Article Biochemistry & Molecular Biology

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

Nathan E. Reticker-Flynn et al.

Summary: Lymph node metastasis plays an active role in shaping distant metastasis in solid malignancies, and this mechanism involves the evasion of immune cells, colonization in lymph nodes, and subsequent colonization in other tissues. This mechanism is conserved in human cancers and murine cancer models.

CELL (2022)

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Article Oncology

Pembrolizumab and maraviroc in refractory mismatch repair proficient/microsatellite-stable metastatic colorectal cancer-The PICCASSO phase I trial

Georg Martin Haag et al.

Summary: This study investigated the safety and efficacy of pembrolizumab and maraviroc in refractory colorectal cancer. The results showed that this treatment was feasible with low toxicity, but had limited clinical activity in mismatch repair proficient colorectal cancer patients.

EUROPEAN JOURNAL OF CANCER (2022)

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Article Immunology

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer

Maxime Meylan et al.

Summary: The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in renal cell carcinoma (RCC). B cells are enriched in TLS and demonstrate diverse maturation stages, with the presence of fully mature clonotypes. Additionally, IgG-and IgA-producing plasma cells (PCs) disseminate into the tumor beds along fibroblastic tracks in TLS+ tumors, indicating potential anti-tumor effector activity. Furthermore, the presence of IgG-stained tumor cells correlates with therapeutic responses and progression-free survival in RCC patients treated with immune checkpoint inhibitors.

IMMUNITY (2022)

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Article Biochemistry & Molecular Biology

Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Tumour Progression in the Regenerating Liver Following Partial Hepatectomy

Georgina E. Riddiough et al.

Summary: This study investigates the potential antitumor effect of renin-angiotensin system inhibition (RASi) in the regenerating liver following partial hepatectomy for colorectal liver metastasis (CRLM). The findings show that RASi treatment reduces tumor burden and alters immune cell composition in the regenerating liver, suggesting that RASi could be explored as an adjunct therapy for patients undergoing partial hepatectomy for CRLM.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Pharmacologic Tumor PDL1 Depletion with Cefepime or Ceftazidime Promotes DNA Damage and Sensitivity to DNA-Damaging Agents

Clare Murray et al.

Summary: The interaction between tumor surface-expressed PDL1 and immune cell PD1 plays a role in evading antitumor immunity, and tumor-intrinsic PDL1 signals can contribute to drug resistance. This study identifies the antibiotic cefepime as a potential drug that can deplete tumor PDL1, increase tumor sensitivity to DNA-damaging agents, and activate immune signals, offering a potential strategy to improve tumor treatment efficacy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O6-Methylguanine-DNA Methyltransferase-Silenced Metastatic Colorectal Cancer: The MAYA Trial

Federica Morano et al.

Summary: This trial evaluated the efficacy and safety of an immune-sensitizing strategy in patients with MSS and MGMT-silenced mCRC. The results showed that a combination of temozolomide priming followed by low-dose ipilimumab and nivolumab may induce durable clinical benefit in these patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Immunology

EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment

Chen Li et al.

Summary: This study investigates the role of EZH2 inhibitors in modulating macrophage polarization in the tumor microenvironment of colorectal cancer. The two different EZH2 inhibitors, EPZ6438 and GSK126, were compared. The findings suggest that EZH2 inhibitors not only suppress CRC cell proliferation directly, but also regulate macrophage polarization to exert a tumor suppressive effect.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Pharmacology & Pharmacy

Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model

Roxanne Wouters et al.

Summary: This study evaluated the effects of different types of particle drug carriers on tumor response and the tumor immune microenvironment. The results showed that some drug carriers caused excessive tumor proliferation, primarily driven by immune suppression. It highlights the importance of evaluating drug carriers before therapeutic use, as they can adversely affect tumor progression and immune status.

PHARMACEUTICS (2022)

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Article Cell Biology

CD73 in small extracellular vesicles derived from HNSCC defines tumour-associated immunosuppression mediated by macrophages in the microenvironment

Tingwei Lu et al.

Summary: Research on tumour cell-derived small extracellular vesicles (sEVs) that regulate tumour microenvironment (TME) has provided strategies for targeted therapy of head and neck squamous cell carcinoma (HNSCC). Herein, we demonstrated that sEVs derived from HNSCC cancer cells carried CD73 (sEVs(CD73)), which promoted malignant progression and mediated immune evasion. The sEVs(CD73) phagocytosed by tumour-associated macrophages (TAMs) in the TME induced immunosuppression.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Biochemistry & Molecular Biology

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

Adrienne M. Luoma et al.

Summary: Neoadjuvant immune checkpoint blockade has promising clinical activity in oral cancer patients, inducing both local and systemic tumor immunity. During treatment, tumor-infiltrating CD8 T cells show elevated tissue-resident memory and cytotoxicity programs, and treatment also induces a systemic immune response.

CELL (2022)

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Article Oncology

Neoadjuvant Chemotherapy Plus Immunotherapy in Early-Stage Resectable Non-Small-Cell Lung Cancer

Antonio Passaro et al.

Summary: The Oncology Grand Rounds series aims to help readers better apply the research findings published in the Journal of Clinical Oncology to patients in their own clinical practice. It includes case presentations, descriptions of diagnostic and management challenges, literature reviews, and suggested treatment approaches.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Immunology

Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8+ T Cells for Enhanced IFNγ Production by Metformin

Ruoyu Chao et al.

Summary: Metformin enhances IFNγ production by CD8(+) T cells through differential metabolic pathways and nutrient conditions, suggesting its potential application in cancer therapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

Mukrime Birgul Akolpoglu et al.

Summary: Bacterial biohybrids controlled by magnetic fields can efficiently deliver drugs to specific regions in 3D biological matrices, demonstrating potential for minimally invasive medicine.

SCIENCE ADVANCES (2022)

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Review Multidisciplinary Sciences

Single-cell technologies: From research to application

Lu Wen et al.

Summary: With the advancement of single-cell technologies, a vast amount of single-cell omics data has been generated, and numerous bioinformatics algorithms have been developed. These single-cell technologies have found successful applications in various fields, including oncology, assisted reproduction, embryonic development, and plant breeding, and are expected to become a booming business for mechanism research and commercial industry in the future.

INNOVATION (2022)

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Article Biochemistry & Molecular Biology

Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth

Ksenija Korac et al.

BIOCHEMICAL JOURNAL (2022)

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Article Oncology

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

Agnieszka Chryplewicz et al.

Summary: This study demonstrates the potential of combination therapy targeting different vulnerabilities in the tumor microenvironment to effectively treat glioblastoma.

CANCER CELL (2022)

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Article Cell & Tissue Engineering

Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance

Xiao-Yan Huang et al.

Summary: This study explored the potential of SN-iPSCs-imDCs for inducing immunotolerance in vitro and in vivo following organ transplantation.

WORLD JOURNAL OF STEM CELLS (2022)

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Review Immunology

Targeting PARP1 to Enhance Anticancer Checkpoint Immunotherapy Response: Rationale and Clinical Implications

Carlos Wagner S. Wanderley et al.

Summary: The use of immune checkpoint inhibitors (ICIs) in cancer treatment has revolutionized the field, but prolonged use of ICIs has resulted in a specific response to certain types of cancer. To overcome resistance and improve outcomes, researchers have explored novel strategies involving the combination of ICIs with other therapies. One promising class of agents is poly ADP-ribose polymerase inhibitors (PARPi), which have the potential to enhance the antitumor immune response through various mechanisms.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Sociology

Single-cell technologies: From research to application

Lu Wen et al.

Summary: In recent years, rapid development of single-cell technologies has led to the generation of a vast amount of single-cell omics data, the development of numerous bioinformatics algorithms, and wide applications in various fields with promising future directions.

INNOVATION-THE EUROPEAN JOURNAL OF SOCIAL SCIENCE RESEARCH (2022)

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Article Multidisciplinary Sciences

Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy

Xiangru Feng et al.

Summary: Conventional chemotherapeutics induce immunogenic cell death in tumor cells, but are limited by the presence of immunosuppressive lymphocytes in the tumor microenvironment. Combining low-dose DOX with 1MT to overcome immune suppression, delivered via a reduction-responsive polypeptide nanogel, effectively suppressed tumor growth and enhanced CD8(+) T cell frequency. The chemoimmunotherapy strategy shows great potential in clinical cancer therapy.

SCIENCE BULLETIN (2021)

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Article Pharmacology & Pharmacy

Nanomedicine and chemotherapeutics drug delivery: challenges and opportunities

Sepideh Nezhadi et al.

Summary: Cancer is a major threat to human health worldwide, with the tumor microenvironment playing a crucial role in cancer progression and treatment outcomes. Understanding and targeting the complex interactions within the microenvironment is essential for developing effective drug delivery systems for cancer therapy.

JOURNAL OF DRUG TARGETING (2021)

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Article Dermatology

The HDAC Inhibitor Domatinostat Promotes Cell-Cycle Arrest, Induces Apoptosis, and Increases Immunogenicity of Merkel Cell Carcinoma Cells

Lina Song et al.

Summary: Merkel cell carcinoma is a rare and highly aggressive skin cancer, with immune modulation by immune checkpoint inhibitors showing promise. However, resistance to immunotherapy remains a significant challenge. Histone deacetylase inhibitors like domatinostat have shown potential to reverse low MHC I expression and increase MCC cells' susceptibility to cytotoxic T cell recognition and elimination.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Oncology

Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): an open-label, nonrandomized, multicenter, phase II trial

B. G. M. Hughes et al.

Summary: The study confirmed the robust anti-tumor activity of pembrolizumab in both locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma patients, showing durable efficacy without unexpected safety signals. Pembrolizumab may be a promising treatment option for these patients.

ANNALS OF ONCOLOGY (2021)

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Article Oncology

Comparing nanoparticle polymeric micellar paclitaxel and solvent-based paclitaxel as first-line treatment of advanced non-small-cell lung cancer: an open-label, randomized, multicenter, phase III trial

M. Shi et al.

Summary: The study demonstrated that pm-Pac plus cisplatin exhibited superior efficacy in terms of higher objective response rate and progression-free survival in patients with advanced NSCLC, along with a favorable safety profile.

ANNALS OF ONCOLOGY (2021)

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Article Engineering, Biomedical

Anticancer nanocage platforms for combined immunotherapy designed to harness immune checkpoints and deliver anticancer drugs

In Seon Jeon et al.

Summary: The use of ferritin nanocages displaying PD-L1pep1 shows potential as an effective immunotherapy by specifically targeting PD-L1 expressed on cancer cells and restoring T cell activities. In a mouse model, these nanocages demonstrated antitumor activity and were more potent when encapsulating the chemotherapeutic drug doxorubicin compared to a monoclonal antibody against PD-L1. This suggests that ferritin nanocages could be a promising immunotherapeutic nanomedicine for solid tumors.

BIOMATERIALS (2021)

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Article Oncology

Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective

Egle Ramelyte et al.

Summary: The study found that intralesional T-VEC treatment in primary cutaneous B cell lymphoma patients led to significant tumor response, rapid eradication of malignant cells, activation of the interferon pathway, and early influx of various immune cells, ultimately resulting in enhanced cellular immunity.

CANCER CELL (2021)

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Article Biochemistry & Molecular Biology

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun et al.

Summary: This study showed that early-relapse hepatocellular carcinoma (HCC) tumors exhibit innate-like CD8(+) T cells with overexpression of KLRB1 (CD161) and a low cytotoxic state, unlike the exhausted state seen in primary HCC. These cells were associated with a worse prognosis. Additionally, potential immune evasion mechanisms were identified in recurrent tumor cells, which dampen dendritic cell antigen presentation and recruit innate-like CD8(+) T cells.

CELL (2021)

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Article Oncology

Statin in combination with cisplatin makes favorable tumor-immune microenvironment for immunotherapy of head and neck squamous cell carcinoma

Minsu Kwon et al.

Summary: The study showed that statins can enhance the anticancer effects of cisplatin, activate antigen-presenting cells, and increase tumor-specific CD8(+) T cells, thus potentiating the efficacy of immunotherapy in HNSCC. The combination of statins with anti-PD-1 antibody further led to tumor eradication and improved survival in tumor-bearing mice. This suggests a potential repurposing of statins as an adjuvant immunotherapeutic option for HNSCC.

CANCER LETTERS (2021)

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Review Chemistry, Multidisciplinary

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

Paula M. Cevaal et al.

Summary: T cells are important in immunity and repair and are implicated in diseases, making them attractive targets for treatment. The use of nanoparticles as carriers for therapeutic cargo has advantages, but delivering nanoparticles to T cells remains a challenge.

ACS NANO (2021)

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Article Oncology

A Phase 1-2 Study of Rovalpituzumab Tesirine in Combination With Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Extensive-Stage SCLC

Jyoti Malhotra et al.

Summary: This study evaluated the safety and efficacy of Rova-T in combination with nivolumab and ipilimumab in previously treated extensive-stage SCLC patients. Despite some patients experiencing treatment-emergent adverse events and serious adverse events, the overall objective response rate was 30% in the combination therapy group.

JOURNAL OF THORACIC ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Pan Zheng et al.

Summary: This study developed an acid-sensitive nanoparticle ((CaCUR)-Ca-PEG) that induces mitochondrial Ca2+ overload and acts as an ICD inducer in improved cancer therapy. Combination with ultrasound (US) enhances the ICD effect, showing promising therapeutic and diagnostic properties.

NANO LETTERS (2021)

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Article Medicine, General & Internal

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

Thomas Powles et al.

Summary: Enfortumab vedotin significantly prolonged survival compared with standard chemotherapy in patients with advanced urothelial carcinoma who had previously received platinum-based treatment and a PD-1 or PD-L1 inhibitor, as well as showing better progression-free survival outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Pan-cancer single cell landscape of tumor-infiltrating T cells

Liangtao Zheng et al.

Summary: This study constructed a pan-cancer atlas of T cells across 21 cancer types, revealing different composition patterns and state-transition paths of T cells. The correlation between certain T cell populations and patient characteristics sheds light on possible determinants of the tumor microenvironment, providing new insights into T cell immunity and precision immunotherapy.

SCIENCE (2021)

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Article Cell Biology

Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer

Christopher A. Chuckran et al.

Summary: Despite the success of immune checkpoint blockade therapy, targeting regulatory T cells (T-regs) within the tumor microenvironment remains a challenge due to the need for specificity to avoid systemic inflammation. Neuropilin-1 (NRP1) is preferentially expressed by intratumoral T-regs and may indicate higher disease burden in patients. NRP1 marks a transient activation state of human T-regs driven by continuous T cell receptor signaling and interleukin-2 exposure.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Chemistry, Medicinal

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Xudong Hu et al.

Summary: This study compared the effects of dezocine and sufentanil on postoperative pain and Th1/Th2 balance in breast cancer patients undergoing surgery, with dezocine found to maintain Th1/Th2 balance more stable.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Medicine, Research & Experimental

Targeted knockdown of the adenosine A2A receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells

Hannah S. Newton et al.

Summary: The study developed a targeted delivery method using lipid nanoparticles to increase the chemotaxis of memory T cells in head and neck squamous cell carcinoma (HNSCC), successfully alleviating the suppressive effect of adenosine on chemotaxis.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Article Oncology

BTK Inhibition Reverses MDSC-Mediated Immunosuppression and Enhances Response to Anti-PDL1 Therapy in Neuroblastoma

Mehreen Ishfaq et al.

Summary: Neuroblastoma (NB) is the most common pediatric malignancy, with high-risk patients showing poor prognosis despite advanced treatments, including immunotherapy. Myeloid-derived suppressor cells (MDSC) play a crucial role in promoting tumor growth and their depletion or blockade has shown benefits in improving responses to immunotherapy in various cancers, including NB. The BTK inhibitor ibrutinib has demonstrated promising results in reducing MDSC-mediated immune suppression, tumor growth, and enhancing response to checkpoint inhibitors in NB, making it a potential therapeutic agent for controlling immune suppression in NB.

CANCERS (2021)

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Review Oncology

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Aukie Hooglugt et al.

Summary: Solid tumors rely on vascularization for growth, with YAP/TAZ activation playing a crucial role in promoting tumor angiogenesis. Understanding the regulation of endothelial YAP/TAZ and its downstream targets is essential for developing effective anti-cancer therapies. Strategies targeting YAP/TAZ in tumor endothelium and exploring vascular normalization may hold promise for improving tumor treatments.

FRONTIERS IN ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Xuan Tan et al.

Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Oncology

A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy

Akemi Kosaka et al.

Summary: Recent studies have shown that tumor cells decrease their immunogenicity by epigenetically repressing highly immunogenic antigens. SPESP1 is identified as a stealth antigen, with its gene being silenced in tumor cells but serving as a potential target for cancer immunotherapy.

CANCER SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells

Nehal Gupta et al.

Summary: Atovaquone reduces the growth of triple-negative breast tumors by decreasing immunosuppressive cells, cytokines, and regulatory T cells in the tumor microenvironment, showing potential as an anticancer therapeutic strategy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

Tissue-resident memory T cells in tumor immunity and immunotherapy

Karolina Okla et al.

Summary: Tissue-resident memory T cells (TRM) reside in peripheral tissues, patrol their surroundings, and rapidly respond to alarming signals. These features enable them to potentially serve as critical players in antitumor surveillance and immunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy

Baicheng Wei et al.

Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.

NANO LETTERS (2021)

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Review Immunology

Role of Epigenetic Regulation in Plasticity of Tumor Immune Microenvironment

Yunkai Yang et al.

Summary: The tumor immune microenvironment (TIME) is crucial in the development, progression, and immune escape of various cancers. Epigenetic alterations can reprogram immune cells in TIME, while the gut microbiome can also influence colorectal cancer and extraintestinal tumors. Tumors are heterogeneous diseases regulated by genetics and epigenetics.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRPα and TIGIT/PVR Pathways for Cancer Immuno-Therapy

Xiuman Zhou et al.

Summary: Strategies that enhance both innate and adaptive immunity show promising applications in cancer immunotherapy. By targeting both CD47/SIRP alpha and TIGIT/PVR pathways, the anti-hypertensive drug azelnidipine has been found to effectively inhibit tumor growth in preclinical studies.

BIOMOLECULES (2021)

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Article Engineering, Biomedical

Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

Shichuan Hu et al.

Summary: In this study, fibroblast activation protein-alpha (FAP) gene-engineered tumor cell-derived exosome-like vesicle vaccines (eNVs-FAP) were developed as a candidate tumor vaccine targeting both the tumor parenchyma and the stroma. The eNVs-FAP vaccine showed excellent antitumor effects by inducing strong and specific CTL immune responses against tumor cells and FAP +CAFs, and reprogramming the immunosuppressive TME in various cancer models. The mechanistic analysis revealed that eNVs-FAP promoted DC maturation, increased effector T cell infiltration, and reduced immunosuppressive cell populations in the TME, leading to enhanced tumor cell ferroptosis.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Engineering Endogenous Tumor-Associated Macrophage-Targeted Biomimetic Nano-RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo-Immunotherapy

Yupeng Wang et al.

Summary: An engineered biomimetic nano-RBC system utilizing hemoglobin is developed to deliver chemotherapy drugs and oxygen, effectively reprogramming the tumor immunosuppressive microenvironment. This strategy targets tumor-associated macrophages and alleviates tumor hypoxia, enhancing the antitumor immune response and inhibiting tumor metastasis and recurrence.

ADVANCED MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Amlexanox enhances the antitumor effect of anti-PD-1 antibody

Kazuhiko Takeda et al.

Summary: Amlexanox enhances the anti-tumor effect of anti-PD-1 mAb by acting on dendritic cells, which in turn activates cytotoxic T cells in tumors.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Engineering, Biomedical

Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade

Soyoung Son et al.

Summary: The study demonstrates that macitentan can modulate the desmoplastic tumor microenvironment by regulating the function of cancer-associated fibroblasts, attenuating the biogenesis of cancer cell-derived exosomes, and modulating T cell subsets and distribution in the TME. These results indicate that macitentan effectively reorganizes the immunosuppressive TME and exhibits synergistic antitumor effects in combination with ICT.

BIOMATERIALS (2021)

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Review Medicine, Research & Experimental

Drug repurposing: Iron in the fire for older drugs

H. V. Sonaye et al.

Summary: Drug repositioning is an attractive approach that can generate lower costs and require a shorter approval time than developing new drugs. The incorporation of different types of data sets can reveal specific features of organism knowledge. Hypothesis-driven in-silico drug repositioning is a new method that takes advantage of big data.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Sydney X. Lu et al.

Summary: The study demonstrates that modulation of splicing through specific drug classes generates genuine neoantigens and enhances anti-tumor immunity, augmenting checkpoint immunotherapy.

CELL (2021)

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Article Immunology

Downregulation of DNMT3a expression by RNAi and its effect on NF-κBs expression of thymic epithelial cells

Fan-Jie Meng et al.

Summary: The study revealed that the expression of DNMT3a protein was lower in thymoma associated with myasthenia gravis compared to thymoma. By constructing a co-expression network of DNMT3a, a direct interaction between IKZF1 and DNMT3a was found, overlapping with the Cistrome DB database. The DNMT3a-NF-kappa B pathway was shown to have a significant effect on myasthenia gravis, indicating its potential as a diagnostic marker and treatment target.

IMMUNOLOGY LETTERS (2021)

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Article Chemistry, Multidisciplinary

Deep Penetration of Nanolevel Drugs and Micrometer-Level T Cells Promoted by Nanomotors for Cancer Immunochemotherapy

Huan Chen et al.

Summary: The study demonstrated that nitric oxide (NO)-driven nanomotors with drug-loading capabilities can significantly improve the infiltration ability of T cells in tumor tissues by promoting normalization of tumor vasculature system and degradation of extracellular matrix (ECM). The combination of motility and physiological function of nanomotors provides a promising design idea for future immunotherapy of various diseases.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biotechnology & Applied Microbiology

Bifunctional TGF-β trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors

Bai Liu et al.

Summary: HCW9218 is a novel immunotherapeutic with dual functions that can activate NK cells and CD8(+) T cells to enhance antitumor activity while also reducing tumor-associated immunosuppression.

MOLECULAR THERAPY (2021)

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Article Engineering, Biomedical

Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition

Mohammad Taleb et al.

Summary: The study demonstrates the use of peptide nanoparticles to modulate both tumor vasculature and immune systems for synergistic tumor suppression. Increasing intratumoral infiltration of immune cells through vascular normalization, while simultaneously inhibiting the PD-L1 immune checkpoint function, reactivates effective immune responses against tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma

Daniel A. Rauch et al.

Summary: Adult T-cell leukemia/lymphoma (ATLL) is a rare but highly malignant tumor caused by human T-cell leukemia virus type 1. A nano-delivery system was developed to inhibit NF-kappa B signaling pathways in tumors by delivering siRNA, resulting in significant tumor growth inhibition and enhanced sensitivity to chemotherapy in late-stage ATLL tumors.

NANOMATERIALS (2021)

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Article Oncology

Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer The REACT Randomized Clinical Trial

R. Charles Coombes et al.

Summary: The Randomized European Celecoxib Trial (REACT) evaluated the role of Celecoxib as an addition to conventional therapy for women with ERBB2-negative primary breast cancer. The study did not find evidence of a disease-free survival benefit for patients receiving 2 years of Celecoxib treatment compared to placebo. Longer-term treatment or higher doses of Celecoxib may need to be explored in further studies to determine potential benefits.

JAMA ONCOLOGY (2021)

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Article Oncology

Depression Induced by CUMS Leads to Bladder Cancer Development and Local Tumor Immunosuppression in Mice

Zhiyu Qian et al.

Summary: Depression is a common mental disease in bladder cancer patients, and chronic unpredictable mild stress can simulate depression in these patients. Depression exacerbates tumor growth, with immune suppression as a possible mechanism.

JOURNAL OF ONCOLOGY (2021)

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Review Immunology

Tumor-draining lymph nodes: At the crossroads of metastasis and immunity

Haley du Bois et al.

Summary: Early engagement of the lymphatic system by solid tumors in peripheral tissues is a clinical hallmark of cancer, often indicating poor prognosis. The significance of lymph node metastasis for distant spread is questioned, while the immunological role of tumor-draining lymph nodes has renewed interest.

SCIENCE IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis

Rami Mustapha et al.

Summary: Tertiary lymphoid structures (TLS) can develop in chronic inflammation and cancer, potentially playing a role in adaptive antitumor immunity but also promoting cancer metastasis. The formation of TLS is closely related to the cytokine and chemokine signature, which is crucial for understanding cancer metastasis and developing cancer immunotherapeutics.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Medicine, Research & Experimental

Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma

Binita Chakraborty et al.

Summary: Research has shown that estrogen signaling through the estrogen receptor plays a significant role in melanoma growth by affecting intratumoral macrophage function, CD8+ T cell activity, and ICB resistance. Targeting estrogen signaling within myeloid cells could potentially reverse immune suppression and enhance the efficacy of ICB in melanoma patients.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Chronic stress promotes breast carcinoma metastasis by accumulating myeloid-derived suppressor cells through activating β-adrenergic signaling

Jiale An et al.

Summary: Chronic stress may accumulate MDSCs via activation of beta-adrenergic signaling and IL-6/STAT3 pathway, thereby promoting breast carcinoma metastasis.

ONCOIMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Entinostat induces antitumor immune responses through immune editing of tumor neoantigens

Andrew S. Truong et al.

Summary: The study highlights the immunomodulatory effects of entinostat on tumor neoantigens, remodeling the tumor immune microenvironment, leading to a strong antitumor response with increased neoantigen-specific T cells. Combination treatment with entinostat and PD-1 blockade results in complete responses and long-term immune memory, providing a strong preclinical rationale.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Medicine, Research & Experimental

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

Hanchen Xu et al.

Summary: The compound atractylenolide I (ATT-I) has been found to enhance tumor antigen presentation and boost the cytotoxic response of CD8(+) T cells by targeting the function of the immunoproteasome, ultimately improving the tumor response to immunotherapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy

Angel Charles et al.

Summary: CDK4/6 inhibitors induce cell-cycle arrest and trigger T-cell immunity, possibly through changes in HLA ligands. In breast cancer cell lines, treatment with CDK4/6 inhibitors leads to upregulation of HLA and induction of new HLA ligands related to the G1/S phase transition, with high likelihood of being recognized by T cells. This suggests that inhibiting a specific cellular process can increase presentation of proteins targeted by immunotherapeutic agents.

ONCOIMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Collagenase-loaded pH-sensitive nanocarriers efficiently remodeled tumor stroma matrixes and improved the enrichment of nanomedicines

Jiading Wang et al.

Summary: By using pH-sensitive nanocarriers loaded with collagenase to remodel the tumor microenvironment, the study successfully enhanced the penetration and enrichment of nanomedicines in the tumor, leading to improved efficacy. The collagenase delivery system not only reduced tumor collagen content and increased the accumulation of antitumor nanomedicines, but also showed no significant toxicity and reduced damage to healthy tissues, indicating potential for enhancing existing delivery systems and drugs for cancer treatment.

NANOSCALE (2021)

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Article Biochemistry & Molecular Biology

HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

Reza Beheshti Zavareh et al.

Summary: Research shows that HSP90 inhibitors can effectively decrease PD-L1 surface expression and modulate the surface expression of other checkpoint proteins, providing further rationale to explore them as part of combination immunotherapies for the treatment of cancer.

CELL CHEMICAL BIOLOGY (2021)

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Article Oncology

Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs

Cesar Oyarce et al.

Summary: The study demonstrates that targeting macrophage cell metabolism can repolarize them from an immunosuppressive M2 phenotype to an anti-tumoral M1-like phenotype. Additionally, it can also prevent M0-to-M2 polarization.

ONCOIMMUNOLOGY (2021)

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Article Oncology

The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy-MONARCH 2 A Randomized Clinical Trial

George W. Sledge et al.

JAMA ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

Vasileios Stathias et al.

NUCLEIC ACIDS RESEARCH (2020)

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Editorial Material Medicine, General & Internal

Tumor Microenvironment, Metabolism, and Immunotherapy

Ralph J. DeBerardinis

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Jenna H. Newman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

VISTA is a checkpoint regulator for naive T cell quiescence and peripheral tolerance

Mohamed A. ElTanbouly et al.

SCIENCE (2020)

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Article Cell Biology

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling

Na Huang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy

Jinglong Tang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic

Tao Sun et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic Nanoconjugate Enables Safe and Efficient Lymphatic Drug Delivery

Bowen Li et al.

NANO LETTERS (2020)

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Article Oncology

The Role of Anti-Angiogenics in Pre-Treated Metastatic BRAF-Mutant Colorectal Cancer: A Pooled Analysis

Fabio Gelsomino et al.

CANCERS (2020)

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Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

David Kolb et al.

ACS NANO (2020)

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Article Immunology

Ascorbic Acid Promotes KIR Demethylation during Early NK Cell Differentiation

Cheng-Ying Wu et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

Patrick A. Ott et al.

CELL (2020)

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Article Multidisciplinary Sciences

An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles

Jiayan Wu et al.

SCIENCE ADVANCES (2020)

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Article Endocrinology & Metabolism

Recombinant Human Thyroid-Stimulating Hormone Increases the Percentages of Natural Killer T Cells and B Lymphocytes in Human Peripheral Blood In Vivo

Zbigniew Adamczewski et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Oncology

Glycosylated Nanoparticles for Cancer-Targeted Drug Delivery

Sergio Andres Torres-Perez et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Medicine, Research & Experimental

TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity

Myrofora Panagi et al.

THERANOSTICS (2020)

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Article Chemistry, Multidisciplinary

Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine

Yuma Yamada et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Targeted delivery of zoledronic acid through the sialic acid - Siglec axis for killing and reversal of M2 phenotypic tumor-associated macrophages - A promising cancer immunotherapy

Xueying Tang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Medicine, Research & Experimental

CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner

Qian-Feng Zhang et al.

THERANOSTICS (2020)

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Article Gastroenterology & Hepatology

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Ivy X. Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Cell Biology

Mutational anc Anticenic Lancsca Tumor Procression anc Cancer Immunotheraoy

Ilio Vitale et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Cell Biology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

Xingzhe Ma et al.

CELL METABOLISM (2019)

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Article Oncology

Cytokine Therapy

Ann W. Silk et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2019)

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Article Immunology

Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade

Brian P. Riesenberg et al.

JOURNAL OF IMMUNOLOGY (2019)

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Review Immunology

IFN-γ: A cytokine at the right time, is in the right place

J. Daniel Burke et al.

SEMINARS IN IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy

Bing Feng et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic Cell

Sooseok Im et al.

ACS NANO (2019)

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Article Biochemistry & Molecular Biology

Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw

Weiwen Zhu et al.

FASEB JOURNAL (2019)

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Article Chemistry, Multidisciplinary

Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy

Wenquan Ou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Cell Biology

Aspirin Disrupts the Crosstalk of Angiogenic and Inflammatory Cytokines between 4T1 Breast Cancer Cells and Macrophages

Chia-Chien Hsieh et al.

MEDIATORS OF INFLAMMATION (2018)

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Article Biotechnology & Applied Microbiology

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Li Tang et al.

NATURE BIOTECHNOLOGY (2018)

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Article Multidisciplinary Sciences

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

Magdalena Jarosz-Biej et al.

PLOS ONE (2018)

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Article Cell Biology

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

David A. Schaer et al.

CELL REPORTS (2018)

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Article Biochemistry & Molecular Biology

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Jong-Ho Cha et al.

MOLECULAR CELL (2018)

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Review Oncology

Targeting minimal residual disease: a path to cure?

Marlise R. Luskin et al.

NATURE REVIEWS CANCER (2018)

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Article Pharmacology & Pharmacy

Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy

Natalia N. Ferreira et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Article Medicine, Research & Experimental

Ibrutinib treatment improves T cell number and function in CLL patients

Meixiao Long et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Obstetrics & Gynecology

Repurposing ospemifene for potentiating an antigen-specific immune response

Chiao-Jung Kao et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2017)

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Article Rheumatology

Chloroquine attenuates TLR3/IFN- signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis

Tadaatsu Imaizumi et al.

MODERN RHEUMATOLOGY (2017)

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Article Multidisciplinary Sciences

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Giovanni Germano et al.

NATURE (2017)

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Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

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Article Multidisciplinary Sciences

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

Takouhie Mgrditchian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

Panagiotis Papageorgis et al.

SCIENTIFIC REPORTS (2017)

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Review Oncology

Targeting immunosuppressive adenosine in cancer

D. Vijayan et al.

NATURE REVIEWS CANCER (2017)

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Article Nanoscience & Nanotechnology

Synergistic Suppression of Tumor Angiogenesis by the Co-delivering of Vascular Endothelial Growth Factor Targeted siRNA and Candesartan Mediated by Functionalized Carbon Nanovectors

Xuefang Ding et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Pharmacology & Pharmacy

Progress in tumor-associated macrophage (TAM)-targeted therapeutics

Chayanon Ngambenjawong et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Synchronized cycles of bacterial lysis for in vivo delivery

M. Omar Din et al.

NATURE (2016)

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Review Immunology

AIRE expands: new roles in immune tolerance and beyond

Mark S. Anderson et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Review Immunology

Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance

Hanyu Zeng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

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Review Chemistry, Multidisciplinary

New Developments in Liposomal Drug Delivery

Bhushan S. Pattni et al.

CHEMICAL REVIEWS (2015)

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Article Biochemistry & Molecular Biology

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana et al.

NATURE MEDICINE (2015)

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Review Biotechnology & Applied Microbiology

Ganetespib: research and clinical development

Komal Jhaveri et al.

ONCOTARGETS AND THERAPY (2015)

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Article Biotechnology & Applied Microbiology

The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies

Akinori Sato

ONCOTARGETS AND THERAPY (2015)

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Article Oncology

Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells

Astrid Authier et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Oncology

Paradoxic effects of metformin on endothelial cells and angiogenesis

Katiuscia Dallaglio et al.

CARCINOGENESIS (2014)

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Article Oncology

Simvastatin plus capecitabine-cisplatin versus placebo plus capecitabine-cisplatin in patients with previously untreated advanced gastric cancer: A double-blind randomised phase 3 study

Seung Tae Kim et al.

EUROPEAN JOURNAL OF CANCER (2014)

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Article Multidisciplinary Sciences

Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma

Jedd D. Wolchok et al.

PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: PRIX GALIEN USA 2012 (2013)

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Article Biochemical Research Methods

In Vivo Targeting of Intratumor Regulatory T Cells Using PEG-Modified Single-Walled Carbon Nanotubes

Cristiano Sacchetti et al.

BIOCONJUGATE CHEMISTRY (2013)

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Article Nanoscience & Nanotechnology

Mouse lymphatic endothelial cell targeted probes: anti-LYVE-1 antibody-based magnetic nanoparticles

Qiu Guo et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Article Multidisciplinary Sciences

Rapid Copper Acquisition by Developing Murine Mesothelioma: Decreasing Bioavailable Copper Slows Tumor Growth, Normalizes Vessels and Promotes T Cell Infiltration

Andrew Crowe et al.

PLOS ONE (2013)

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Article Cell Biology

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

Laurie Menger et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Review Medicine, Research & Experimental

Applications of Functionalized Fullerenes in Tumor Theranostics

Zhiyun Chen et al.

THERANOSTICS (2012)

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Article Oncology

Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer

Holger Bronger et al.

BREAST CANCER RESEARCH (2012)

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Article Oncology

Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study

Thomas P. Ahern et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)

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Review Physiology

NORMALIZATION OF THE VASCULATURE FOR TREATMENT OF CANCER AND OTHER DISEASES

Shom Goel et al.

PHYSIOLOGICAL REVIEWS (2011)

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Article Immunology

Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

Jarish N. Cohen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

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Article Oncology

Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients

Paola Nistico et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Article Immunology

Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response

Gabrielle A. Rizzuto et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

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Article Immunology

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

N Casares et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Article Oncology

Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma

S Brem et al.

NEURO-ONCOLOGY (2005)

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Review Immunology

The immunobiology of cancer immunosurveillance and immunoediting

GP Dunn et al.

IMMUNITY (2004)

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Review Medicine, Research & Experimental

Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease

GJ Brewer

EXPERIMENTAL BIOLOGY AND MEDICINE (2001)

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Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

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