Related references
Note: Only part of the references are listed.Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis
Jinkun Wen et al.
MOLECULAR THERAPY (2022)
Exerkines in health, resilience and disease
Lisa S. Chow et al.
NATURE REVIEWS ENDOCRINOLOGY (2022)
Irisin: A promising treatment for neurodegenerative diseases
Jing-yu Qi et al.
NEUROSCIENCE (2022)
Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information
Chuanmei Zhu et al.
CANCER LETTERS (2022)
Central FGF21 production regulates memory but not peripheral metabolism
Bolu Zhou et al.
CELL REPORTS (2022)
Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes
Tingting Fu et al.
OBESITY FACTS (2022)
Current Clinical Applications of In Vivo Gene Therapy with AAVs
Jerry R. Mendell et al.
MOLECULAR THERAPY (2021)
Levels of 13-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21
Ricardo Moure et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
Emmanouela Tsagkaraki et al.
NATURE COMMUNICATIONS (2021)
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
Chady H. Hakim et al.
NATURE COMMUNICATIONS (2021)
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
Mohammadsharif Tabebordbar et al.
CELL (2021)
Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway
Yang Mu et al.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)
Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
Edward E. Large et al.
VIRUSES-BASEL (2021)
Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy
Joan Bertolin et al.
NATURE COMMUNICATIONS (2021)
Role of Irisin in Endocrine and Metabolic Disorders-Possible New Therapeutic Agent?
Letitia Leustean et al.
APPLIED SCIENCES-BASEL (2021)
Identification of the downstream molecules of agrin/Dok-7 signaling in muscle
Beibei Wang et al.
FASEB JOURNAL (2020)
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors
Dan Wang et al.
CELL (2020)
AAV Vectors: Are They Safe?
Arun Srivastava
HUMAN GENE THERAPY (2020)
CRISPR-based functional genomics for neurological disease
Martin Kampmann
NATURE REVIEWS NEUROLOGY (2020)
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Chih-Hao Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Dynamic folding modulation generates FGF21 variant against diabetes
Lei Zhu et al.
EMBO REPORTS (2020)
Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans
Amos Baruch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1
Aixia Sui et al.
NEUROCHEMISTRY INTERNATIONAL (2019)
Fibroblast growth factor 21 controls mitophagy and muscle mass
Lynette J. Oost et al.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)
AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy
Rithu Pattali et al.
GENE THERAPY (2019)
A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene
Dwi U. Kemaladewi et al.
NATURE (2019)
Recombinant Proteins for Industrial versus Pharmaceutical Purposes: A Review of Process and Pricing
John Puetz et al.
PROCESSES (2019)
Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
Lidia L. Arhire et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity
Guangchuan Wang et al.
NATURE IMMUNOLOGY (2019)
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
Matthias J. Betz et al.
NATURE REVIEWS ENDOCRINOLOGY (2018)
FGF21 gene therapy as treatment for obesity and insulin resistance
Veronica Jimenez et al.
EMBO MOLECULAR MEDICINE (2018)
Expression, purification and biological characterisation of recombinant human irisin (12.5 kDa)
Kalpana Panati et al.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2018)
Crosstalk between adipokines and myokines in fat browning
A. Rodriguez et al.
ACTA PHYSIOLOGICA (2017)
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Christoph Hoffmann et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Muscle as a paracrine and endocrine organ
Jimena Giudice et al.
CURRENT OPINION IN PHARMACOLOGY (2017)
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
Antonia A. Dominguez et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Saswata Talukdar et al.
CELL METABOLISM (2016)
Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice
Huikun Duan et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)
Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9
Joana Saraiva et al.
JOURNAL OF CONTROLLED RELEASE (2016)
The therapeutic potential of brown adipocytes in humans
Craig Porter et al.
FRONTIERS IN ENDOCRINOLOGY (2015)
Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
Paul Lee et al.
CELL METABOLISM (2014)
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Yuan Zhang et al.
DIABETES (2014)
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
Samir Mitragotri et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Adipose tissue browning and metabolic health
Alexander Bartelt et al.
NATURE REVIEWS ENDOCRINOLOGY (2014)
The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
Gregory Gaich et al.
CELL METABOLISM (2013)
Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance
Jose Mara Moreno-Navarrete et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway
Julieta Diaz-Delfin et al.
ENDOCRINOLOGY (2012)
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Bostroem et al.
NATURE (2012)
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Bente K. Pedersen et al.
NATURE REVIEWS ENDOCRINOLOGY (2012)
Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences
Christine Aurnhammer et al.
HUMAN GENE THERAPY METHODS (2012)
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu et al.
DIABETES (2009)
Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals
Bente K. Pedersen et al.
EXPERIMENTAL PHYSIOLOGY (2009)
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
Alexei Kharitonenkov et al.
ENDOCRINOLOGY (2007)
FGF-21 as a novel metabolic regulator
A Kharitonenkov et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Primary adipocyte culture: Adipocyte purification methods may lead to a new understanding of adipose tissue growth and development
ME Fernyhough et al.
CYTOTECHNOLOGY (2004)