4.8 Article

Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

Editorial Material Engineering, Biomedical

Conductive and Electroactive Biomaterials and Bioelectronics

Mehdi Nikkhah et al.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Multidisciplinary

All-in-One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed-Release of Exosome and Fibroblast Growth Factor

Yuan Xiong et al.

Summary: The novel HA@MnO2/FGF-2/Exos hydrogel can improve diabetic wound healing by forming a protective barrier and providing long-term antibacterial protection, while utilizing MnO2/ε-PL nanosheets to catalyze H2O2 conversion to O-2, releasing M2 Exos and FGF-2 to promote the healing process.

SMALL (2022)

Article Cell Biology

The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng et al.

Summary: Foot ulcers in diabetic patients are often caused by various factors leading to slow wound healing, in which oxidative stress and antioxidants play important roles. By reducing oxidative stress levels, oxidative damage can be minimized to facilitate wound healing.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Medical Laboratory Technology

Macrophage polarization and diabetic wound healing

Amanda E. Louiselle et al.

Summary: Research has shown that the polarization state of macrophages plays a crucial role in diabetic wound healing, with normal wounds transitioning to pro-healing M2 macrophages while diabetic wounds continue to exhibit pro-inflammatory M1 macrophage polarization. Targeting factors that promote M2 macrophage polarization and treatments aimed at reducing hyperglycemia and pro-inflammatory cytokines may be key in improving diabetic wound healing outcomes.

TRANSLATIONAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Silvia Fernandez-Francos et al.

Summary: Stem cells, especially mesenchymal stem cells, have shown therapeutic effects in various clinical conditions due to their ability to control a range of intercellular signals. However, limitations such as safety issues and high cost have led to a growing trend towards considering the use of MSC-derived secretome products as a therapeutic tool.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury

Yunsi Zheng et al.

Summary: Prolonged exposure to high glucose leads to mitochondrial fragmentation, triggering cell apoptosis and vascular injury. AMPK is suppressed by high glucose, causing imbalanced mitochondrial fusion/fission, which can be reversed with AMPK stimulation, serving as a predictive factor for diabetic cardiovascular complications.

BIOMOLECULES (2021)

Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

Article Nanoscience & Nanotechnology

An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing

Feifei Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Cell Biology

SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement

Shengju Yang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Cell & Tissue Engineering

Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances

Roel C. Op't Veld et al.

TISSUE ENGINEERING PART B-REVIEWS (2020)

Review Chemistry, Multidisciplinary

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

Meadhbh A. Brennan et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Cell Biology

Macrophage mediation in normal and diabetic wound healing responses

Goutham V. Ganesh et al.

INFLAMMATION RESEARCH (2020)

Review Biochemistry & Molecular Biology

Research status of self-healing hydrogel for wound management: A review

Andi Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Allergy

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Peter A. Nigrovic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress

Xiaoqiang Li et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Review Engineering, Biomedical

Recent advances in biomaterials for 3D scaffolds: A review

Maria P. Nikolova et al.

BIOACTIVE MATERIALS (2019)

Article Medical Laboratory Technology

Mitochondrial regulation of diabetic vascular disease: an emerging opportunity

Michael E. Widlansky et al.

TRANSLATIONAL RESEARCH (2018)

Review Immunology

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Simon A. Jones et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Dermatology

The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery

Naghmeh Naderi et al.

INTERNATIONAL WOUND JOURNAL (2017)

Editorial Material Medicine, General & Internal

Management of a Diabetic Foot

Theodore Hart et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Review Cell & Tissue Engineering

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

Donald G. Phinney et al.

STEM CELLS (2017)

Review Endocrinology & Metabolism

Macro- and microvascular endothelial dysfunction in diabetes

Yi Shi et al.

JOURNAL OF DIABETES (2017)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Susana Rovira-Llopis et al.

REDOX BIOLOGY (2017)

Article Nanoscience & Nanotechnology

pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing

Lingling Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Endocrinology & Metabolism

Metformin: historical overview

Clifford J. Bailey

DIABETOLOGIA (2017)

Article Biochemistry & Molecular Biology

Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy

Sebastien Preau et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Editorial Material Biochemistry & Molecular Biology

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose

Julien Prudent et al.

CURRENT BIOLOGY (2016)

Article Cell Biology

Actin filaments as dynamic reservoirs for Drp1 recruitment

Anna L. Hatch et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Article Nanoscience & Nanotechnology

Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes

Andrea Masotti et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Review Endocrinology & Metabolism

Peripheral arterial disease and revascularization of the diabetic foot

R. O. Forsythe et al.

DIABETES OBESITY & METABOLISM (2015)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Biotechnology & Applied Microbiology

Carbon nanotubes leading the way forward in new generation 3D tissue engineering

Erin Leigh Hopley et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Dermatology

Wound Dressings: Selecting the Most Appropriate Type

Karen C. Broussard et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2013)

Review Cell Biology

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

Monica Giannotta et al.

DEVELOPMENTAL CELL (2013)

Review Cardiac & Cardiovascular Systems

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

Francesco Paneni et al.

EUROPEAN HEART JOURNAL (2013)

Review Biochemistry & Molecular Biology

Oxidative stress and vascular inflammation in aging

Mariam El Assar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Multidisciplinary Sciences

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Mikael M. Martino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cardiac & Cardiovascular Systems

Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

Sherene M. Shenouda et al.

CIRCULATION (2011)

Article Anatomy & Morphology

The Cutaneous Microvascular Architecture of Human Diabetic Toe Studied by Corrosion Casting and Scanning Electron Microscopy Analysis

S. Sangiorgi et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2010)

Article Endocrinology & Metabolism

Global estimates of the prevalence of diabetes for 2010 and 2030

J. E. Shaw et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2010)

Review Hematology

VE-cadherin - The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation

Dietmar Vestweber

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

Review Engineering, Biomedical

Investigation on clotting and hemolysis characteristics of heparin-immobilized polyether sulfones biomemabrane

Changjun Hou et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

Article Computer Science, Interdisciplinary Applications

Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles

Yanping Liu et al.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2008)

Review Cardiac & Cardiovascular Systems

Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

Jeanette Schultz Johansen et al.

CARDIOVASCULAR DIABETOLOGY (2005)

Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)