Roles of MT-ND1 in Cancer

The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.

Automated summary

The energy shift to glycolysis is a characteristic of cancer. MT-ND1, encoded by mitochondria, is a crucial subunit of complex I necessary for oxidative phosphorylation. This study reviews the structure, biological function, and expression patterns/mutations of MT-ND1 in various cancers, suggesting its potential as a biomarker for cancer diagnosis and prognosis, as well as a target for cancer therapy.