5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog

ObjectiveTo describe a case of 5-hydroxytryptophan (5-HTP) toxicity successfully treated with haemodialysis in a dog.Case SummaryA 3-year-old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4-5 h after ingesting a human supplement containing 200 mg of 5-HTP. The amount of 5-HTP ingested was estimated between 980 and 1988 mg (35-71 mg/kg). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, including altered mentation and ataxia. Due to the magnitude of the ingested dose and progression of clinical signs, extracorporeal blood purification with intermittent haemodialysis was chosen to expedite clearance of 5-HTP. High-efficiency haemodialysis was initiated, and the dog showed continued clinical improvement throughout the 5-h treatment. Clinical signs resolved completely within 12 h. Sequential blood and urine samples were obtained to document levels of both 5-HTP and serotonin. The dog was discharged 24 h after presentation with complete resolution of clinical signs.New or Unique InformationThis is the first report documenting the serial changes in 5-HTP concentrations during treatment with haemodialysis. A 3-year-old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4-5 h after ingesting a human supplement containing 200 mg of 5-hydroxytryptophan (5-HTP). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, and high-efficiency haemodialysis was initiated as treatment. The dog showed continued clinical improvement throughout the 5-h treatment. To the authors' knowledge, this is the first report documenting the serial changes in 5-HTP concentrations during treatment with haemodialysis.image

Automated summary

This article describes a case of 5-hydroxytryptophan (5-HTP) toxicity in a dog successfully treated with haemodialysis. The dog presented to the emergency department approximately 4-5 hours after ingesting a human supplement containing 200 mg of 5-HTP, showing progressive neurologic abnormalities consistent with serotonin syndrome. High-efficiency haemodialysis was initiated and the dog showed continued clinical improvement throughout the 5-hour treatment, with complete resolution of clinical signs within 12 hours.