Journal
NATURE NEUROSCIENCE
Volume 19, Issue 11, Pages 1477-1488Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4400
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Funding
- Simons Foundation (Simons Center for the Social Brain, Massachusetts Institute of Technology)
- Natural Science and Engineering Council of Canada
- JPB Foundation
- NIH U01 grant [MH106018-03]
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De novo mutations in CHD8 are strongly associated with autism spectrum disorder, but the basic biology of CHD8 remains poorly understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately manifests in abnormal neuronal morphology and behaviors in adult mice. Transcriptome analysis revealed that while Chd8 stimulates the transcription of cell cycle genes, it also precludes the induction of neural specific genes by regulating the expression of PRC2 complex components. Furthermore, knockdown of Chd8 disrupts the expression of key transducers of Writ signaling, and enhancing Wnt signaling rescues the transcriptional and behavioral deficits caused by Chd8 knockdown. We propose that these roles of Chd8 and the dynamics of Chd8 expression during development help negotiate the fine balance between neural progenitor proliferation and differentiation. Together, these observations provide new insights into the neurodevelopmental role of Chd8.
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