Journal
NATURE NEUROSCIENCE
Volume 19, Issue 12, Pages 1563-1565Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4404
Keywords
-
Categories
Funding
- Knut and Alice Wallenberg Foundation [2015.0327]
- Swedish Research Council [2016-00250]
- Royal Netherlands Academy of Science [PAH/6635]
- Finnish Foundation for Cardiovascular Research
- National Human Genome Research Institute [U54 HG003067, R01 HG006855]
- National Institute of Mental Health [1U01MH105666-01, 1R01MH101244-02]
- National Institute of Diabetes and Digestive and Kidney Disease [1U54DK105566-02]
- Stanley Center for Psychiatric Research
- Alexander and Margaret Stewart Trust
- National Institutes of Mental Health [R01 MH077139, RC2 MH089905]
- Sylvan C. Herman Foundation
- EU [692145, 676550, 654248]
- Estonian Research Council [IUT20-60]
- NIASC
- EIT-Health
- NIH-BMI Grant [2R0IDK075787-06A1]
- EU through the European Regional Development Fund [2014-2020.4.01.15-0012 GENTRANSMED]
- Swedish Research Council [2016-00250] Funding Source: Swedish Research Council
- Forte [2016-00250] Funding Source: Forte
Ask authors/readers for more resources
Disruptive, damaging ultra-rare variants in highly constrained genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE). This effect was stronger among highly brain-expressed genes and explained more YOE variance than pathogenic copy number variation but less than common variants. Disruptive, damaging ultra-rare variants in highly constrained genes influence the determinants of YOE in the general population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
