Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

The deleterious effects of chemical or non-chemical endocrine disruptors (EDs) on male fertility potential is well documented but still not fully elucidated. For example, the detection of industrial chemicals' metabolites in seminal plasma and follicular fluid can affect efficiency of the gametogenesis, the maturation and competency of gametes and has guided scientists to hypothesize that endocrine disrupting chemicals (EDCs) may disrupt hormonal homoeostasis by leading to a wide range of hormonal control impairments. The effects of EDCs exposure on reproductive health are highly dependent on factors including the type of EDCs, the duration of exposure, individual susceptibility, and the presence of other co-factors. Research and scientists continue to study these complex interactions. The aim of this review is to summarize the literature to better understand the potential reproductive health risks of EDCs in France.

Automated summary

The detrimental effects of endocrine disruptors on male fertility have been well documented but not fully understood. Industrial chemicals' metabolites found in seminal plasma and follicular fluid can affect gametogenesis, gamete maturation, and competency, leading to hormonal control impairments. The effects of EDCs exposure on reproductive health depend on various factors, including the type of EDCs, duration of exposure, individual susceptibility, and co-factors. Further research is ongoing to understand these complex interactions. This review aims to summarize the literature on the potential reproductive health risks of EDCs in France.