Journal
NATURE NEUROSCIENCE
Volume 19, Issue 6, Pages 845-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nn.4287
Keywords
-
Categories
Funding
- Pew Foundation
- McKnight Foundation
- NARSAD Foundation
- Sloan Foundation
- NIH DP2 New Innovator Award [R01 MH106689-02]
- NSF Graduate Research Fellowship
- Essig and Enright '82 Fund
Ask authors/readers for more resources
Dopaminergic (DA) neurons in the midbrain provide rich topographic innervation of the striatum and are central to learning and to generating actions. Despite the importance of this DA innervation, it remains unclear whether and how DA neurons are specialized on the basis of the location of their striatal target. Thus, we sought to compare the function of subpopulations of DA neurons that target distinct striatal subregions in the context of an instrumental reversal learning task. We identified key differences in the encoding of reward and choice in dopamine terminals in dorsal versus ventral striatum: DA terminals in ventral striatum responded more strongly to reward consumption and reward-predicting cues, whereas DA terminals in dorsomedial striatum responded more strongly to contralateral choices. In both cases the terminals encoded a reward prediction error. Our results suggest that the DA modulation of the striatum is spatially organized to support the specialized function of the targeted subregion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available