Journal
NATURE NANOTECHNOLOGY
Volume 11, Issue 11, Pages 977-985Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nnano.2016.164
Keywords
-
Funding
- National Institutes of Health [R01GM111350, 1R01CA161280-01A1, 1U54 CA199081-01, R01GM113013, R01CA166413]
- Sloan Kettering Institute Core Grant [P30 CA008748CCSG]
- Benjamin Friedman Research Fund
Ask authors/readers for more resources
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10 nm in diameter) poly (ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available