4.6 Review

Esophageal Mucosal Resistance in Reflux Esophagitis: What We Have Learned So Far and What Remains to Be Learned

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review

Rena Yadlapati et al.

Summary: This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms and provides detailed recommendations for clinical practice.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Biochemistry & Molecular Biology

Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases

Tanay Kaymak et al.

Summary: The esophagus is an understudied anatomical immune segment that may contribute to inflammatory esophageal diseases due to its unique anatomical and physiological characteristics.

FEBS JOURNAL (2022)

Editorial Material Gastroenterology & Hepatology

Risk-stratification models for Barrett's esophagus: Will we get to the perfect classifier?

Man Wai Chan et al.

GASTROINTESTINAL ENDOSCOPY (2022)

Review Biochemistry & Molecular Biology

Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett's Esophagus and Esophageal Adenocarcinoma

Jan Bilski et al.

Summary: Both obesity and esophageal adenocarcinoma (EAC) rates have seen a significant increase in recent years in the United States and Western Europe. Obesity plays a key role in the development of EAC, with increased body mass index correlating with higher risk. Pathologically altered visceral fat in obesity is believed to contribute to this process. Visceral obesity may promote EAC through direct effects on gastroesophageal reflux disease and Barrett's esophagus (BE), as well as through the release of pro-inflammatory adipokines and insulin resistance. Disrupted adipokine production, such as the imbalance of leptin and adiponectin, is implicated in the pathogenesis of BE and EAC. This review discusses the epidemiology, pathophysiology, and molecular alterations associated with obesity in BE and EAC, with a focus on the potential role of adipokines and myokines. The review also highlights the possible crosstalk of adipokines and myokines during exercise and suggests lifestyle interventions, specifically regular physical activity, as a promising strategy for preventing the development of BE and EAC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Cell Biology

The Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett's Esophagus

Deqiang Han et al.

Summary: Barrett's esophagus is a major complication of gastro-esophageal reflux disease and an important precursor lesion for the development of Barrett's metaplasia and esophageal adenocarcinoma. This review discusses the mechanisms of Barrett's metaplasia and adenocarcinoma underlying oxidative DNA damage in gastro-esophageal reflux disease patients based on recent clinical and basic findings.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Medicine, General & Internal

Local inflammatory response to gastroesophageal reflux: Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

Sergey Morozov et al.

Summary: This study aims to explore the gene expression of inflammatory cytokines in esophageal mucosa of patients with EE and NERD, and its association with esophageal MII-pH measurements.

WORLD JOURNAL OF CLINICAL CASES (2022)

Article Gastroenterology & Hepatology

Severity of GERD and disease progression

K. H. Fuchs et al.

Summary: In analyzing GERD patients under long-term proton pump inhibitor therapy with persistent symptoms, it was found that factors such as LES incompetence, hiatal hernia, and increased acid exposure were associated with disease severity and progression. Path modeling revealed a causal sequence of the main disease parameters over time, potentially allowing for prediction of the disease course.

DISEASES OF THE ESOPHAGUS (2021)

Review Biochemistry & Molecular Biology

Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease

Zhi Zheng et al.

Summary: GERD is a common clinical disease with increasing incidence due to improvements in living standards and changes in lifestyle. However, the mechanism of GERD remains unclear and therapeutic outcomes are unsatisfactory. Exploring the pathogenesis and finding effective treatment methods have become the focus of scholars' attention.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

Tight junctions and their regulation by non-coding RNAs

Xiaojiao Zhao et al.

Summary: Tight junction (TJ) is a zipping up junction structure located at the uppermost portion of adjacent epithelial/endothelial cells in organs and tissues, maintaining the stability of intracellular substances and functions. TJs are widely present in various organs and tissues, dysfunction of which can lead to various diseases, and they are also regulated by non-coding RNAs.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Gastroenterology & Hepatology

Prevalence of Gastroesophageal Reflux Disease and Proton Pump Inhibitor-Refractory Symptoms

Sean D. Delshad et al.

GASTROENTEROLOGY (2020)

Review Biochemistry & Molecular Biology

The multifarious regulation of the apical junctional complex

Alexandra D. Rusu et al.

OPEN BIOLOGY (2020)

Review Multidisciplinary Sciences

Recent insights into the biology of Barrett's esophagus

Henry Badgery et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

Review Physiology

OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions

Eszter Becskehazi et al.

FRONTIERS IN PHYSIOLOGY (2020)

Editorial Material Biochemistry & Molecular Biology

Special Issue on The Tight Junction and Its Proteins: More than Just a Barrier

Susanne M. Krug et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, General & Internal

Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma

Jerry Zhou et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Gastroenterology & Hepatology

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma

L. C. Duits et al.

DISEASES OF THE ESOPHAGUS (2019)

Review Gastroenterology & Hepatology

Mucin Expression in the Esophageal Malignant and Pre-malignant States A Systematic Review and Meta-analysis

Yaron Niv et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2018)

Article Cell Biology

Cell-Cell Junctions Organize Structural and Signaling Networks

Miguel A. Garcia et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Review Gastroenterology & Hepatology

The Esophageal Epithelial Barrier in Health and Disease

Christopher H. Blevins et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus

William M. Grady et al.

DIGESTIVE DISEASES AND SCIENCES (2018)

Article Gastroenterology & Hepatology

Modern diagnosis of GERD: the Lyon Consensus

C. Prakash Gyawali et al.

Article Gastroenterology & Hepatology

Obesity and GERD impair esophageal epithelial permeability through 2 distinct mechanisms

C. H. Blevins et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Article Cell Biology

Some of the effective factors in the pathogenesis of gastro-oesophageal reflux disease

Fatemeh Nejat Pish-Kenari et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Gastroenterology & Hepatology

The esophageal microbiota in health and disease

Vincenzo Di Pilato et al.

13TH OESO WORLD CONFERENCE: THE ESOPHAGIOME II (2016)

Review Gastroenterology & Hepatology

Gastrointestinal mucosal barrier function and diseases

Tadayuki Oshima et al.

JOURNAL OF GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Diagnosis by endoscopy and advanced imaging

A. Swager et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma

Andrew M. Kaz et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2015)

Editorial Material Gastroenterology & Hepatology

Changes in the esophageal mucosa of patients with non erosive reflux disease: How far have we gone?

Christos Triantos et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

Esophageal Epithelial Resistance

Claudia Guenther et al.

DIGESTIVE DISEASES (2014)

Article Gastroenterology & Hepatology

Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn

Edoardo Savarino et al.

JOURNAL OF GASTROENTEROLOGY (2013)

Review Pharmacology & Pharmacy

The oral microbiome in health and disease

William G. Wade

PHARMACOLOGICAL RESEARCH (2013)

Article Gastroenterology & Hepatology

Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

Ricard Farre et al.

Review Gastroenterology & Hepatology

Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis

Florian Rieder et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Gastroenterology & Hepatology

The integrity of the esophageal mucosa Balance between offensive and defensive mechanisms

Roy C. Orlando

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2010)

Article Cardiac & Cardiovascular Systems

Prognostic value of p53 mutations in oesophageal adenocarcinoma: final results of a 15-year prospective study

Koroush Madani et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2010)

Article Microbiology

The Human Oral Microbiome

Floyd E. Dewhirst et al.

JOURNAL OF BACTERIOLOGY (2010)

Article Anatomy & Morphology

Immunohistochemical Overexpression of the p53 Protein and Ki-67 (MIB-1) Antigen in Patients With GERD and Chronic Esophagitis

Marcelo Binato et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2010)

Review Oncology

Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis

Brian J. Reid et al.

NATURE REVIEWS CANCER (2010)

Article Gastroenterology & Hepatology

P53 and Ki-67 overexpression in gastroesophageal reflux disease - Barrett's esophagus and adenocarcinoma sequence

M. Binato et al.

DISEASES OF THE ESOPHAGUS (2009)

Article Cardiac & Cardiovascular Systems

MicroRNA expression profiles of esophageal cancer

Andrew Feber et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2008)

Article Gastroenterology & Hepatology

A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease

Prateek Sharma et al.

GASTROENTEROLOGY (2007)

Review Gastroenterology & Hepatology

The montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus

Nimish Vakil et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

Article Gastroenterology & Hepatology

Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium

NA Tobey et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2004)